Research ArticleProceedings of the Joint International Symposium “Vitamin D in Prevention and Therapy” and “Biologic Effects of Light”, 5-7 June, 2019 (Homburg/Saar, Germany)

Variable Genomic and Metabolomic Responses to Varying Doses of Vitamin D Supplementation

ARASH SHIRVANI, TYLER AREK KALAJIAN, ANJELI SONG, RACHEL ALLEN, NIPITH CHAROENNGAM, RICHARD LEWANCZUK and MICHAEL F. HOLICK
Anticancer Research January 2020, 40 (1) 535-543; DOI: https://doi.org/10.21873/anticanres.13982

Article Figures & Data

Figures

  • Figure 1.
    Figure 1.

    Total concentration of PTH and 25(OH)D during vitamin D3 supplementation at baseline and every eight weeks for 24 weeks. This figure is reproduced with permission (8).

  • Figure 2.
    Figure 2.

    Visualization the gene expression alterations in response to 10,000 IU/day vitamin D3 supplementation. The gene-expression alterations are demonstrated by different colors. Upregulation and downregulation of gene expression after 6-months vitamin D3 supplementation showed by red and blue, respectively. Trends of gene expression are seen by range of colors from light blue to dark red. The red, white and blue represented of high, average and low gene expression, respectively. This figure is reproduced with permission (8).

  • Figure 3.
    Figure 3.

    Protein-Protein Interaction (PPI) Network was constructed from differentially upregulated genes contributing to immune system-related pathways after 6-month supplementation with vitamin D3.

  • Figure 4.
    Figure 4.

    The PCA score plot of the study groups. There was not any pattern of separation in the differential metabolites between 600 IU/day (blue dots) and 10,000 IU/day groups (green dots).

  • Figure 5.
    Figure 5.

    The PCA score plot of the vitamin D in the more responsive and less responsive groups. The score plot resulted in unambiguous inter-group separation. Differential metabolites in the vitamin D more responsive group are shown by diamond dots and in the less responsive by circle dots. The large circle points to the metabolites with the most discriminating power between vitamin D more responsive and less responsive groups.

Tables

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  • Table III.
  • Table IV.
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Variable Genomic and Metabolomic Responses to Varying Doses of Vitamin D Supplementation
ARASH SHIRVANI, TYLER AREK KALAJIAN, ANJELI SONG, RACHEL ALLEN, NIPITH CHAROENNGAM, RICHARD LEWANCZUK, MICHAEL F. HOLICK
Anticancer Research Jan 2020, 40 (1) 535-543; DOI: 10.21873/anticanres.13982
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