Research ArticlePROCEEDINGS OF THE 22nd ANNUAL MEETING OF THE SOCIETY OF BIOTHERAPEUTIC APPROACHES, December 8, 2018 (Tokyo, Japan)

Sinusoidal Obstruction Syndrome and Postoperative Complications Resulting from Preoperative Chemotherapy for Colorectal Cancer Liver Metastasis

TORU HISAKA, HIROTO ISHIKAWA, HISAMUNE SAKAI, RYUICHI KAWAHARA, YUICHI GOTO, YORIKO NOMURA, MASAFUMI YASUNAGA, TETSUSHI KINUGASA, FUMIHIKO FUJITA, TOMOAKI MIZOBE, MASARU FUKAHORI, KEISUKE MIWA, OSAMU NAKASHIMA, MASAHIKO TANIGAWA, YOSHIKI NAITO, JUN AKIBA, HIROHISA YANO, HIROYUKI TANAKA, YOSHITO AKAGI and KOJI OKUDA
Anticancer Research August 2019, 39 (8) 4549-4554; DOI: https://doi.org/10.21873/anticanres.13632

Article Figures & Data

Figures

  • Figure 1.
    Figure 1.

    Photomicrograph of sinusoidal injuries. Sinusoidal dilation showed irregular distribution, reaching the neighboring hepatic lobules (HE staining, ×20).

  • Figure 2.
    Figure 2.

    Photomicrographs of sinusoidal injuries. (A) Hepatic cord configuration became obscure, and reticular fiber intricacies and disruptions were observed (Silver impregnation staining, ×200). (B) Proliferation of collagen fibers was confirmed (Masson trichrome staining, ×200), (C) along with CD34 positive findings matching the mutated sinusoidal endothelial cells (CD34 immunostaining, ×200). (D) At the same sites, α-SMA positive myofibroblasts were observed (α-SMA immunostaining, ×200).

Tables

  • Table I.
  • Table II.
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Sinusoidal Obstruction Syndrome and Postoperative Complications Resulting from Preoperative Chemotherapy for Colorectal Cancer Liver Metastasis
TORU HISAKA, HIROTO ISHIKAWA, HISAMUNE SAKAI, RYUICHI KAWAHARA, YUICHI GOTO, YORIKO NOMURA, MASAFUMI YASUNAGA, TETSUSHI KINUGASA, FUMIHIKO FUJITA, TOMOAKI MIZOBE, MASARU FUKAHORI, KEISUKE MIWA, OSAMU NAKASHIMA, MASAHIKO TANIGAWA, YOSHIKI NAITO, JUN AKIBA, HIROHISA YANO, HIROYUKI TANAKA, YOSHITO AKAGI, KOJI OKUDA
Anticancer Research Aug 2019, 39 (8) 4549-4554; DOI: 10.21873/anticanres.13632
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