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Research ArticlePROCEEDINGS OF THE 22nd ANNUAL MEETING OF THE SOCIETY OF BIOTHERAPEUTIC APPROACHES, December 8, 2018 (Tokyo, Japan)

Preventive Effect of Oral Administration of Pantoea agglomerans-derived LPS in a Hypertensive Rat Model Upon Salt Loading

RAN ZHANG, HIROYUKI INAGAWA, SACHIKO UCHIBORI, TSUTOMU MASAKI, HIDEKI KOBARA and GEN-ICHIRO SOMA
Anticancer Research August 2019, 39 (8) 4503-4509; DOI: https://doi.org/10.21873/anticanres.13626
RAN ZHANG
1R&D Division, Control of Innate Immunity, Technology Research Association, Kagawa, Japan
2R&D Division, Umeken CO., LTD, Osaka, Japan
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  • For correspondence: zhang{at}shizenmeneki.org
HIROYUKI INAGAWA
1R&D Division, Control of Innate Immunity, Technology Research Association, Kagawa, Japan
3Niigata University of Pharmacy and Applied Life Sciences, Niigata, Japan
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SACHIKO UCHIBORI
1R&D Division, Control of Innate Immunity, Technology Research Association, Kagawa, Japan
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TSUTOMU MASAKI
4Department of Gastroenterology and Neurology, Faculty of Medicine, Kagawa University, Kagawa, Japan
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HIDEKI KOBARA
4Department of Gastroenterology and Neurology, Faculty of Medicine, Kagawa University, Kagawa, Japan
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GEN-ICHIRO SOMA
1R&D Division, Control of Innate Immunity, Technology Research Association, Kagawa, Japan
3Niigata University of Pharmacy and Applied Life Sciences, Niigata, Japan
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    Figure 1.

    Changes in blood pressure over time in the WKY-DW group, DW group and LPS group. SBP (A), DBP (B) and MBP (C) were measured at 6 weeks old, 10 weeks old, 13 weeks old, 16 weeks old rats. Black: WKY-DW group, gray: DW group, light gray: LPS group. The data are presented as mean±SEM and were obtained from 2-4 rats per group. *p<0.05, **p<0.01, ***p<0.001 compared to the WKY-DW group.

  • Figure 2.
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    Figure 2.

    Changes in blood pressure over time in the WKY-DW group, Na group and Na+LPS group. SBP (A), DBP (B) and MBP (C) were measure at 6 weeks old, 10 weeks old, 13 weeks old, 16 weeks old rats. Black: WKY-DW group, gray: Na group, light gray: Na+LPS group. The data are presented as mean±SEM and were obtained from 2-4 rats per group. *p<0.05, **p<0.01, ***p<0.001 compared to the WKY-DW group.

  • Figure 3.
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    Figure 3.

    The levels of plasma biochemical markers in the DW group, LPS group, Na group and Na+LPS group. ALT: alanine aminotransferase (A), AST: Aspartate transaminase (B), T-BIL: total bilirubin (C), TG: triacylglycerol (D), HDL-C: high density lipoprotein cholesterol (E), LDL-C: low density lipoprotein cholesterol (F), OxLDL /LDL: oxidized LDL/LDL (G), T-CHO: total cholesterol (H). The data are presented as mean±SEM and were obtained from 2-4 rats per group.

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    Figure 4.

    Gut microbiota composition in the DW group, LPS group, Na group and Na+LPS group. Variations in bacterial community compositions in stool samples at the phylum levels. The ratio of Bacteroidetes to Firmicutes (B). Principal component analysis results from stool samples of DW and LPS group (C). C: Black circle: DW group; Gray circle: LPS group. Principal component analysis results from stool samples of Na and Na+LPS group (D). D: Black circle: Na group; Gray circle: Na+LPS group. The data were obtained from 2-4 rats per group.

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Anticancer Research
Vol. 39, Issue 8
August 2019
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Preventive Effect of Oral Administration of Pantoea agglomerans-derived LPS in a Hypertensive Rat Model Upon Salt Loading
RAN ZHANG, HIROYUKI INAGAWA, SACHIKO UCHIBORI, TSUTOMU MASAKI, HIDEKI KOBARA, GEN-ICHIRO SOMA
Anticancer Research Aug 2019, 39 (8) 4503-4509; DOI: 10.21873/anticanres.13626

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Preventive Effect of Oral Administration of Pantoea agglomerans-derived LPS in a Hypertensive Rat Model Upon Salt Loading
RAN ZHANG, HIROYUKI INAGAWA, SACHIKO UCHIBORI, TSUTOMU MASAKI, HIDEKI KOBARA, GEN-ICHIRO SOMA
Anticancer Research Aug 2019, 39 (8) 4503-4509; DOI: 10.21873/anticanres.13626
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Keywords

  • Hypertensive
  • salt loading
  • Pantoea agglomerans-derived LPS
  • oral administration
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