Anticancer Research: 39 (7)

July 2019; Volume 39,Issue 7

Special Issue on New Anticancer Agents

Reviews

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A Systematic Review and Meta-analysis of the Combination of Vinorelbine and Lapatinib in Patients With Her2-positive Metastatic Breast Cancer
ATHINA STRAVODIMOU and IOANNIS A. VOUTSADAKIS

Anticancer Research July 2019, 39 (7) 3295-3301; DOI: https://doi.org/10.21873/anticanres.13471
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To Combine or Not Combine: Drug Interactions and Tools for Their Analysis. Reflections from the EORTC-PAMM Course on Preclinical and Early-phase Clinical Pharmacology
BTISSAME EL HASSOUNI, GIULIA MANTINI, GIOVANNA LI PETRI, MJRIAM CAPULA, LENKA BOYD, HANNAH N.W. WEINSTEIN, ANDREA VALLÉS-MARTI, MATHILDE C.M. KOUWENHOVEN, ELISA GIOVANNETTI, BART A. WESTERMAN, GODEFRIDUS J. PETERS and on Behalf of the EORTC PAMM Group

Anticancer Research July 2019, 39 (7) 3303-3309; DOI: https://doi.org/10.21873/anticanres.13472
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The Role of PEDF in Pancreatic Cancer
DANIEL ANSARI, CARL ALTHINI, HENRIK OHLSSON, MONIKA BAUDEN and ROLAND ANDERSSON

Anticancer Research July 2019, 39 (7) 3311-3315; DOI: https://doi.org/10.21873/anticanres.13473
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The Hippo Signaling Pathway in Pancreatic Cancer
DANIEL ANSARI, HENRIK OHLSSON, CARL ALTHINI, MONIKA BAUDEN, QIMIN ZHOU, DINGYUAN HU and ROLAND ANDERSSON

Anticancer Research July 2019, 39 (7) 3317-3321; DOI: https://doi.org/10.21873/anticanres.13474
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Drug Delivery Systems for Phthalocyanines for Photodynamic Therapy
JAKUB RAK, PAVLA POUCKOVA, JIRI BENES and DAVID VETVICKA

Anticancer Research July 2019, 39 (7) 3323-3339; DOI: https://doi.org/10.21873/anticanres.13475
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From ‘Targeted Therapy’ to Targeted Therapy
GODEFRIDUS J. PETERS

Anticancer Research July 2019, 39 (7) 3341-3345; DOI: https://doi.org/10.21873/anticanres.13476
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Regulation of BS69 Expression in Cancers
YUN CHEN, YA-HUI TSAI and SHENG-HONG TSENG

Anticancer Research July 2019, 39 (7) 3347-3351; DOI: https://doi.org/10.21873/anticanres.13477
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Potential Molecular Mechanisms of the Anti-cancer Activity of Vitamin D
DOROTA SKRAJNOWSKA and BARBARA BOBROWSKA-KORCZAK

Anticancer Research July 2019, 39 (7) 3353-3363; DOI: https://doi.org/10.21873/anticanres.13478
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Therapy Aimed to Suppress the Production of the Immunosuppressive Protein Progesterone Induced Blocking Factor (PIBF) May Provide Palliation and/or Increased Longevity for Patients With a Variety of Different Advanced Cancers – A Review
JEROME H. CHECK and DIANE CHECK

Anticancer Research July 2019, 39 (7) 3365-3372; DOI: https://doi.org/10.21873/anticanres.13479
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Glucans as New Anticancer Agents
PETR SIMA, JOSEF RICHTER and VACLAV VETVICKA

Anticancer Research July 2019, 39 (7) 3373-3378; DOI: https://doi.org/10.21873/anticanres.13480
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Inhibitors of Protein Tyrosine Phosphatase PTP1B With Anticancer Potential
TOMASZ KOSTRZEWA, JOANNA STYSZKO, MAGDALENA GORSKA-PONIKOWSKA, TOMASZ SLEDZINSKI and ALICJA KUBAN-JANKOWSKA

Anticancer Research July 2019, 39 (7) 3379-3384; DOI: https://doi.org/10.21873/anticanres.13481
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Acyl-Coenzyme A: Cholesterol Acyltransferase Inhibition in Cancer Treatment
JUDYTA ZABIELSKA, TOMASZ SLEDZINSKI and EWA STELMANSKA

Anticancer Research July 2019, 39 (7) 3385-3394; DOI: https://doi.org/10.21873/anticanres.13482
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Extracellular Vesicles: Subcellular Organelles With the Potential to Spread Cancer Resistance
FANNY ENDER, NIKOLAS VON BUBNOFF and FRANK GIESELER

Anticancer Research July 2019, 39 (7) 3395-3404; DOI: https://doi.org/10.21873/anticanres.13483
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State of the Art for Metastatic Pancreatic Cancer Treatment: Where Are We Now?
RITA BALSANO, CHIARA TOMMASI and INGRID GARAJOVA

Anticancer Research July 2019, 39 (7) 3405-3412; DOI: https://doi.org/10.21873/anticanres.13484
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A Brief Guide to Performing Pharmacological Studies In Vitro: Reflections from the EORTC-PAMM Course “Preclinical and Early-phase Clinical Pharmacology”
MJRIAM CAPULA, CRISTINA CORNO, BTISSAME EL HASSOUNI, GIOVANNA LI PETRI, SANDRA ARANĐELOVIĆ and on Behalf of the EORTC PAMM Group

Anticancer Research July 2019, 39 (7) 3413-3418; DOI: https://doi.org/10.21873/anticanres.13485
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Is There Any Room for Pharmacometrics With Immuno-Oncology Drugs? Input from the EORTC-PAMM Course on Preclinical and Early-phase Clinical Pharmacology
ANNE RODALLEC, RAPHAELLE FANCIULLINO, SEBASTIEN BENZEKRY, JOSEPH CICCOLINI and on Behalf of the EORTC PAMM Group

Anticancer Research July 2019, 39 (7) 3419-3422; DOI: https://doi.org/10.21873/anticanres.13486
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Pleiotropic Chemotherapy to Abrogate Glioblastoma Multiforme Migration/Invasion
LAWRENCE HELSON and MUHAMMED MAJEED

Anticancer Research July 2019, 39 (7) 3423-3427; DOI: https://doi.org/10.21873/anticanres.13487
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In Vitro Anticancer Activities of B₆ Vitamers: A Mini-review
TAISUKE MATSUO and YASUYUKI SADZUKA

Anticancer Research July 2019, 39 (7) 3429-3432; DOI: https://doi.org/10.21873/anticanres.13488

Experimental Studies

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Biochemical Inhibition of DOG1/TMEM16A Achieves Antitumoral Effects in Human Gastrointestinal Stromal Tumor Cells In Vitro
ROBIN FRÖBOM, FELIX SELLBERG, CHENG XU, ALLAN ZHAO, CATHARINA LARSSON, WENN-ONN LUI, INGA-LENA NILSSON, ERIK BERGLUND and ROBERT BRÄNSTRÖM

Anticancer Research July 2019, 39 (7) 3433-3442; DOI: https://doi.org/10.21873/anticanres.13489
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Oxidative DNA Damage and Apoptosis Induced by Aclarubicin, an Anthracycline: Role of Hydrogen Peroxide and Copper
HIDEKI MIZUTANI, YUKA HAYASHI, MIYABI HASHIMOTO, MASANORI IMAI, YOSHIMI ICHIMARU, YUKI KITAMURA, KENJI IKEMURA, DAISUKE MIYAZAWA, KINYA OHTA, YOSHIAKI IKEDA, TOHRU MAEDA, MASAE YOSHIKAWA, YUSUKE HIRAKU and SHOSUKE KAWANISHI

Anticancer Research July 2019, 39 (7) 3443-3451; DOI: https://doi.org/10.21873/anticanres.13490
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Unravelling the Antiproliferative Activity of 1,2,5-oxadiazole Derivatives
DANIEL EHRSAM, FABIOLA PORTA, MATTEO MORI, HENRIETTE E. MEYER ZU SCHWABEDISSEN, LISA DALLA VIA, AÌDA NELLY GARCIA-ARGAEZ, LIVIA BASILE, FIORELLA MENEGHETTI, STEFANIA VILLA and ARIANNA GELAIN

Anticancer Research July 2019, 39 (7) 3453-3461; DOI: https://doi.org/10.21873/anticanres.13491
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Peritoneal Metastases in a Patient-derived Orthotopic Xenograft (PDOX) Model of Colon Cancer Imaged Non-invasively via Red Fluorescent Protein Labeled Stromal Cells
JUN HO PARK, MING ZHAO, HIROMICHI OSHIRO, KENTARO MIYAKE, TAKASHI HIGUCHI, JOSE REYNOSO, SAHAR RAZMJOOEI, MICHAEL BOUVET, BRYAN CLARY, ZHIYING ZHANG, NORIHIKO SUGISAWA, JUN YAMAMOTO, SHREE RAM SINGH and ROBERT M. HOFFMAN

Anticancer Research July 2019, 39 (7) 3463-3467; DOI: https://doi.org/10.21873/anticanres.13492
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Natural and Synthetic Isothiocyanates Possess Anticancer Potential Against Liver and Prostate Cancer In Vitro
EMILY CROWLEY, NEIL J. ROWAN, DON FALLER and ANNE M. FRIEL

Anticancer Research July 2019, 39 (7) 3469-3485; DOI: https://doi.org/10.21873/anticanres.13493
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Acyclic Retinoid Combined With Tenascin-C-derived Peptide Reduces the Malignant Phenotype of Neuroblastoma Cells Through N-Myc Degradation
KAZUKI OTSUKA, MANABU SASADA, YU HIRANO, YUSUKE NOHARA, TAKUYA IYODA, YOSHIKAZU HIGAMI, HIROAKI KODAMA and FUMIO FUKAI

Anticancer Research July 2019, 39 (7) 3487-3492; DOI: https://doi.org/10.21873/anticanres.13494
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IL-29 Exhibits Anti-Tumor Effect on Pan-48 Pancreatic Cancer Cells by Up-regulation of P21 and Bax
DEAN BALABANOV, LEI ZHAO, ZIWEN ZHU, ZACHARY E. HUNZEKER, HANNAH M. TONNER, VIVI A. DING, MARK R. WAKEFIELD, QIAN BAI and YUJIANG FANG

Anticancer Research July 2019, 39 (7) 3493-3498; DOI: https://doi.org/10.21873/anticanres.13495
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Phenformin Induces Caspase-dependent Apoptosis of FaDu Head and Neck Squamous Cell Carcinoma Cells
YO-SEOB SEO, TAE-HYEON KIM, HYANGI LIM, JI-SU OH, JAE-SEEK YOU, GYEONG-JE LEE, SUN-KYOUNG YU, DO KYUNG KIM, HEUNG-JOONG KIM, CHUN SUNG KIM, SOOK-YOUNG LEE, SU-GWAN KIM and JAE-SUNG KIM

Anticancer Research July 2019, 39 (7) 3499-3506; DOI: https://doi.org/10.21873/anticanres.13496
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Quantitative Structure–Cytotoxicity Relationship of Azulene Amide Derivatives
KANA IMANARI, MASASHI HASHIMOTO, HIDETSUGU WAKABAYASHI, NORIYUKI OKUDAIRA, KENJIRO BANDOW, JUNKO NAGAI, MINEKO TOMOMURA, AKITO TOMOMURA, YOSHIHIRO UESAWA and HIROSHI SAKAGAMI

Anticancer Research July 2019, 39 (7) 3507-3518; DOI: https://doi.org/10.21873/anticanres.13497
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Induction of Non-Apoptotic Cell Death by Adrenergic Agonists in Human Oral Squamous Cell Carcinoma Cell Lines
SHIGENORI UCHIDA, KATSUE KOBAYASHI, SEIKA OHNO, HIROSHI SAKAGAMI, HIKARU KOHASE and HIROSHI NAGASAKA

Anticancer Research July 2019, 39 (7) 3519-3529; DOI: https://doi.org/10.21873/anticanres.13498
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Simultaneous Inhibition of Protein Kinase CK2 and Dihydrofolate Reductase Results in Synergistic Effect on Acute Lymphoblastic Leukemia Cells
PATRYCJA WIŃSKA, ŁUKASZ WIDŁO, KATARZYNA SKIERKA, ALICJA KRZYŚKO, MIROSŁAWA KORONKIEWICZ, JAROSŁAW M. CIEŚLA, JOANNA CIEŚLA and MARIA BRETNER

Anticancer Research July 2019, 39 (7) 3531-3542; DOI: https://doi.org/10.21873/anticanres.13499
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Bevacizumab Versus Anti-preeclamptic Drugs: Evaluation With Three-dimensionally Co-cultured Human Mini Tumors
CHEN PAN, KENJI ONDA and TOSHIHIKO HIRANO

Anticancer Research July 2019, 39 (7) 3543-3551; DOI: https://doi.org/10.21873/anticanres.13500
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Schlafen11 Expression Is Associated With the Antitumor Activity of Trabectedin in Human Sarcoma Cell Lines
JUNYA IWASAKI, TOSHIHARU KOMORI, FUMIO NAKAGAWA, HIDEKI NAGASE, JUNJI UCHIDA, KENICHI MATSUO and YOSHIHIRO UTO

Anticancer Research July 2019, 39 (7) 3553-3563; DOI: https://doi.org/10.21873/anticanres.13501
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ChIP-seq Analysis to Explore DNA Replication Profile in Trifluridine-treated Human Colorectal Cancer Cells In Vitro
TAKASHI KOBUNAI, KAZUAKI MATSUOKA and TEIJI TAKECHI

Anticancer Research July 2019, 39 (7) 3565-3570; DOI: https://doi.org/10.21873/anticanres.13502
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Down-regulation of Survivin by BIX-01294 Pretreatment Overcomes Resistance of Hepatocellular Carcinoma Cells to TRAIL
YENA NAMGUNG, SO YOUNG KIM and INKI KIM

Anticancer Research July 2019, 39 (7) 3571-3578; DOI: https://doi.org/10.21873/anticanres.13503
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Combined Inhibition of ALK and HDAC Induces Synergistic Cytotoxicity in Neuroblastoma Cell Lines
KAZUMI HAGIWARA, TAKASHI TOKUNAGA, HIROATSU IIDA and HIROKAZU NAGAI

Anticancer Research July 2019, 39 (7) 3579-3584; DOI: https://doi.org/10.21873/anticanres.13504
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Broad-spectrum Cross-resistance to Anticancer Drugs Mediated by Epidermal Growth Factor Receptor
GE YAN and THOMAS EFFERTH

Anticancer Research July 2019, 39 (7) 3585-3593; DOI: https://doi.org/10.21873/anticanres.13505
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Perampanel Inhibits Neuroblastoma Cell Proliferation Through Down-regulation of AKT and ERK Pathways
AKIFUMI NOZAWA, MICHIO OZEKI, MIKAKO MATSUOKA, MINA NAKAMA, SHIHO YASUE, SAORI ENDO, NORIO KAWAMOTO, HIDENORI OHNISHI and TOSHIYUKI FUKAO

Anticancer Research July 2019, 39 (7) 3595-3599; DOI: https://doi.org/10.21873/anticanres.13506
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The Involvement of Pregnane X Receptor-regulated Pathways in the Antitumor Activity of Cisplatin
MEGUMI YASUDA, SHUICHI KISHIMOTO, MANABU AMANO and SHOJI FUKUSHIMA

Anticancer Research July 2019, 39 (7) 3601-3608; DOI: https://doi.org/10.21873/anticanres.13507
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Uridine Cytidine Kinase 2 as a Potential Biomarker for Treatment with RX-3117 in Pancreatic Cancer
BTISSAME EL HASSOUNI, JESSICA INFANTE, GIULIA MANTINI, CLAUDIO RICCI, NICCOLA FUNEL, ELISA GIOVANNETTI and GODEFRIDUS J. PETERS

Anticancer Research July 2019, 39 (7) 3609-3614; DOI: https://doi.org/10.21873/anticanres.13508
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Biological Evaluation of the Antiproliferative and Anti-migratory Activity of a Series of 3-(6-Phenylimidazo[2,1-b][1,3,4]thiadiazol-2-yl)-1H-indole Derivatives Against Pancreatic Cancer Cells
GIOVANNA LI PETRI, STELLA CASCIOFERRO, BTISSAME EL HASSOUNI, DANIELA CARBONE, BARBARA PARRINO, GIROLAMO CIRRINCIONE, GODEFRIDUS J. PETERS, PATRIZIA DIANA and ELISA GIOVANNETTI

Anticancer Research July 2019, 39 (7) 3615-3620; DOI: https://doi.org/10.21873/anticanres.13509
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Cetrimonium Bromide Inhibits Cell Migration and Invasion of Human Hepatic SK-HEP-1 Cells Through Modulating the Canonical and Non-canonical TGF-β Signaling Pathways
TSAI-KUN WU, CHUNG-HUNG CHEN, YING-RU PAN, CHING-WEN HU, FU-MEI HUANG, JER-YUH LIU and CHIA-JEN LEE

Anticancer Research July 2019, 39 (7) 3621-3631; DOI: https://doi.org/10.21873/anticanres.13510
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DL-Methadone as an Enhancer of Chemotherapeutic Drugs in Head and Neck Cancer Cell Lines
VERONIKA LANDGRAF, MATTHIAS GRIESSMANN, JEANETTE ROLLER, CHRISTINE POLEDNIK and MARIANNE SCHMIDT

Anticancer Research July 2019, 39 (7) 3633-3639; DOI: https://doi.org/10.21873/anticanres.13511
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Amentoflavone Induces Apoptosis and Reduces Expression of Anti-apoptotic and Metastasis-associated Proteins in Bladder Cancer
CHIH-HUNG CHIANG, CHING-YI YEH, JING GUNG CHUNG, I-TSANG CHIANG and FEI-TING HSU

Anticancer Research July 2019, 39 (7) 3641-3649; DOI: https://doi.org/10.21873/anticanres.13512
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Inhibition of Pancreatic Carcinoma Growth Through Enhancing ω-3 Epoxy Polyunsaturated Fatty Acid Profile by Inhibition of Soluble Epoxide Hydrolase
RONG XIA, LEYU SUN, JIE LIAO, HAONAN LI, XIAOMING YOU, DANDAN XU, JUN YANG, SUNG HEE HWANG, RYAN D. JONES, BRUCE HAMMOCK and GUANG-YU YANG

Anticancer Research July 2019, 39 (7) 3651-3660; DOI: https://doi.org/10.21873/anticanres.13513
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Selective Wnt/β-catenin Small-molecule Inhibitor CWP232228 Impairs Tumor Growth of Colon Cancer
JIN YOUNG KIM, GEUMI PARK, MANIGANDAN KRISHNAN, EUNYOUNG HA and KYUNG-SOO CHUN

Anticancer Research July 2019, 39 (7) 3661-3667; DOI: https://doi.org/10.21873/anticanres.13514
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Suppression of ERK/NF-κB Activation Is Associated With Amentoflavone-Inhibited Osteosarcoma Progression In Vivo
YEN-JU LEE, JING-GUNG CHUNG, YI-TING CHIEN, SONG-SHEI LIN and FEI-TING HSU

Anticancer Research July 2019, 39 (7) 3669-3675; DOI: https://doi.org/10.21873/anticanres.13515
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Peroxiredoxin V Reduces β-Lapachone-induced Apoptosis of Colon Cancer Cells
YUE LIU, TAEHO KWON, JI-SU KIM, NISANSALA CHANDIMALI, YING-HUA JIN, YI-XI GONG, DAN-PING XIE, YING-HAO HAN, MEI-HUA JIN, GUI-NAN SHEN, DONG KEE JEONG, DONG-SUN LEE, YU-DONG CUI and HU-NAN SUN

Anticancer Research July 2019, 39 (7) 3677-3686; DOI: https://doi.org/10.21873/anticanres.13516
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Autophagy Promotes Survival of CHP-212 Neuroblastoma Cells Treated With Casiopeínas®
ADRIANA VÁZQUEZ-AGUIRRE, ANLLELY GRIZETT GUTIÉRREZ, RAFAEL MORENO ESPARZA, ENRIQUE HERNÁNDEZ-LEMUS, LENA RUIZ-AZUARA and CARMEN MEJÍA

Anticancer Research July 2019, 39 (7) 3687-3695; DOI: https://doi.org/10.21873/anticanres.13517
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The Ethanol Crude Extraction of Cyperus Rotundus Regulates Apoptosis-associated Gene Expression in HeLa Human Cervical Carcinoma Cells In Vitro
CHIA-HSIN LIN, SHU-FEN PENG, FU-SHIN CHUEH, ZHENG-YU CHENG, CHAO-LIN KUO and JING-GUNG CHUNG

Anticancer Research July 2019, 39 (7) 3697-3709; DOI: https://doi.org/10.21873/anticanres.13518
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Cisplatin and Vinorelbine -Mediated Electrochemotherapeutic Approach Against Multidrug Resistant Small Cell Lung Cancer (H69AR) In Vitro
MAŁGORZATA DRĄG-ZALESIŃSKA, JOLANTA SACZKO, ANNA CHOROMAŃSKA, ANNA SZEWCZYK, NINA REMBIAŁKOWSKA, JULITA KULBACKA and ADAM RZECHONEK

Anticancer Research July 2019, 39 (7) 3711-3718; DOI: https://doi.org/10.21873/anticanres.13519
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Interleukin-24 Transduction Modulates Human Prostate Cancer Malignancy Mediated by Regulation of Anchorage Dependence
SHOTARO MAEHANA, YUTA MATSUMOTO, FUMIAKI KOJIMA and HIDERO KITASATO

Anticancer Research July 2019, 39 (7) 3719-3725; DOI: https://doi.org/10.21873/anticanres.13520
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Combination of Vaccine Strain Measles Virus and Nimotuzumab in the Treatment of Laryngeal Cancer
NGUYEN LINH TOAN, NGO THU HANG, NGUYEN KIM LUU, CAN VAN MAO, NGUYEN VAN BA, NGUYEN THI XUAN, TRUONG DINH CAM, NAOKI YAMAMOTO, HOANG VAN TONG and HO ANH SON

Anticancer Research July 2019, 39 (7) 3727-3737; DOI: https://doi.org/10.21873/anticanres.13521
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Differential Response of BEAS-2B and H-441 Cells to Methylene Blue Photoactivation
ROSALVA JOSEFINA RODRÍGUEZ-CÓRDOVA, CINDY ALEJANDRA GUTIÉRREZ-VALENZUELA, PASANO BOJANG, REYNALDO ESQUIVEL, PEDRO HERNÁNDEZ, KENNETH S. RAMOS, ROBERTO GUZMÁN-ZAMUDIO and ARMANDO LUCERO-ACUÑA

Anticancer Research July 2019, 39 (7) 3739-3744; DOI: https://doi.org/10.21873/anticanres.13522
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Resveratrol Modulates the Redox-status and Cytotoxicity of Anticancer Drugs by Sensitizing Leukemic Lymphocytes and Protecting Normal Lymphocytes
DONIKA IVANOVA, ZHIVKO ZHELEV, SEVERINA SEMKOVA, ICHIO AOKI and RUMIANA BAKALOVA

Anticancer Research July 2019, 39 (7) 3745-3755; DOI: https://doi.org/10.21873/anticanres.13523
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Co-treatment With HIV Protease Inhibitor Nelfinavir Greatly Increases Late-phase Apoptosis of Drug-resistant KBV20C Cancer Cells Independently of P-Glycoprotein Inhibition
JI YEONG KIM, YOO JUNG PARK, BYUNG-MU LEE and SUNGPIL YOON

Anticancer Research July 2019, 39 (7) 3757-3765; DOI: https://doi.org/10.21873/anticanres.13524
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Histamine Receptor Antagonists, Loratadine and Azelastine, Sensitize P-gp-overexpressing Antimitotic Drug-resistant KBV20C Cells Through Different Molecular Mechanisms
JI YEONG KIM, KYEONG SEOK KIM, IN SU KIM and SUNGPIL YOON

Anticancer Research July 2019, 39 (7) 3767-3775; DOI: https://doi.org/10.21873/anticanres.13525
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Selenoesters and Selenoanhydrides as Novel Agents Against Resistant Breast Cancer
ANDREA CSONKA, ANNAMÁRIA KINCSES, MÁRTA NOVÉ, ZSÓFIA VADAS, CARMEN SANMARTÍN, ENRIQUE DOMÍNGUEZ-ÁLVAREZ and GABRIELLA SPENGLER

Anticancer Research July 2019, 39 (7) 3777-3783; DOI: https://doi.org/10.21873/anticanres.13526
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Tyrosine Kinase Inhibitors Imatinib and Erlotinib Increase Apoptosis of Antimitotic Drug-resistant KBV20C Cells Without Inhibiting P-gp
JI YEONG KIM, HYUNG SIK KIM and SUNGPIL YOON

Anticancer Research July 2019, 39 (7) 3785-3793; DOI: https://doi.org/10.21873/anticanres.13527
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In Vitro Evaluation of Apoptotic Induction of Butyric Acid Derivatives in Colorectal Carcinoma Cells
LIJI PATTAYIL and HARIKUMARAN-THAMPI BALAKRISHNAN-SARASWATHI

Anticancer Research July 2019, 39 (7) 3795-3801; DOI: https://doi.org/10.21873/anticanres.13528
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AXL Downstream Targeting Unravels Synergistic Drug Combinations in Ovarian Carcinoma Cells
DESIRÈ M. ALAMPI, EMILIO CIUSANI, NIVES CARENINI, ELISABETTA CORNA, LAURA GATTI and CRISTINA CORNO

Anticancer Research July 2019, 39 (7) 3803-3808; DOI: https://doi.org/10.21873/anticanres.13529
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2-Deoxy-glucose Enhances the Effect of Cisplatin and Pemetrexed in Reducing Malignant Pleural Mesothelioma Cell Proliferation But Not Spheroid Growth
IRINI GEROGIANNI, ELEANNA PITARAKI, RAJESH M. JAGIRDAR, OLYMPIA KOULIOU, LYDIA GIANNAKOU, STEFANOS GIANNOPOULOS, ELEFTHERIOS PAPAZOGLOU, CHRISSI HATZOGLOU, KONSTANTINOS I. GOURGOULIANIS and SOTIRIOS G. ZAROGIANNIS

Anticancer Research July 2019, 39 (7) 3809-3814; DOI: https://doi.org/10.21873/anticanres.13530
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In Vivo Effectiveness of Orlistat in the Suppression of Human Colorectal Cancer Cell Proliferation
ALEKSANDRA CZUMAJ, JUDYTA ZABIELSKA, ALICJA PAKIET, ADRIANA MIKA, OLGA ROSTKOWSKA, WOJCIECH MAKAREWICZ, JAROSŁAW KOBIELA, TOMASZ SLEDZINSKI and EWA STELMANSKA

Anticancer Research July 2019, 39 (7) 3815-3822; DOI: https://doi.org/10.21873/anticanres.13531
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Virtual Screening of 1,4-Naphthoquinone Derivatives for Inhibition of a Key Cancer Signaling Protein, AKT1 Kinase
MOHD REHAN and MAGED MOSTAFA

Anticancer Research July 2019, 39 (7) 3823-3833; DOI: https://doi.org/10.21873/anticanres.13532
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Lupane Triterpenoids and New Derivatives as Antiproliferative Agents Against Prostate Cancer Cells
MARÍA JULIA CASTRO, VALERIA PILAR CAREAGA, PAULA ALEJANDRA SACCA, MARÍA BELÉN FARAONI, ANA PAULA MURRAY and JUAN CARLOS CALVO

Anticancer Research July 2019, 39 (7) 3835-3845; DOI: https://doi.org/10.21873/anticanres.13533

Clinical Studies

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Marking Disappearing Colorectal Liver Metastases After Complete Response to Neoadjuvant Chemotherapy via CT – A Pilot Study
JOVAN VUJIC, HELMUT SCHÖLLNAST, KATHARINA MARSONER, VALERIE WIENERROITHER, HEINZ BACHER, HANS-JÖRG MISCHINGER and PETER KORNPRAT

Anticancer Research July 2019, 39 (7) 3847-3854; DOI: https://doi.org/10.21873/anticanres.13534
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Follow-up Results of HCV GT2 Patients After Sofosbuvir/Ribavirin Therapy: Careful Attention to Occurrence of HCC
TOMOHIRO KANEKO, TATSUO KANDA, KAZUSHIGE NIREI, NAOKI MATSUMOTO, MOTOMI YAMAZAKI, TOSHIKATSU SHIBATA, AKINORI TAMURA, MASAHIRO OGAWA, NORIKO NAKAJIMA, SHUNICHI MATSUOKA, KAZUMICHI KURODA, TOMOE KOMORIYA, TATSUO YAMAMOTO, TADATOSHI TAKAYAMA and MITSUHIKO MORIYAMA

Anticancer Research July 2019, 39 (7) 3855-3862; DOI: https://doi.org/10.21873/anticanres.13535
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Matrix-producing Carcinoma as an Aggressive Triple-negative Breast Cancer: Clinicopathological Features and Response to Neoadjuvant Chemotherapy
KAZUHIRO SHIMADA, TAKASHI ISHIKAWA, AKIMITSU YAMADA, SADATOSHI SUGAE, KAZUTAKA NARUI, DAISUKE SHIMIZU, TAKASHI CHISHIMA and ITARU ENDO

Anticancer Research July 2019, 39 (7) 3863-3869; DOI: https://doi.org/10.21873/anticanres.13536
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Clinical Characteristics Associated With Lenvatinib-induced Fistula and Tumor-related Bleeding in Patients With Thyroid Cancer
YUKIKO STAUB, AKIHIRO NISHIYAMA, YUKIO SUGA, MIKIYA FUJITA, RYO MATSUSHITA and SEIJI YANO

Anticancer Research July 2019, 39 (7) 3871-3878; DOI: https://doi.org/10.21873/anticanres.13537
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Flutamide as an Alternative Anti-androgen Agent and Predictor of the Efficacy of Novel Androgen Receptor-targeted Agents
NORIYA YAMAGUCHI, SHUICHI MORIZANE, TETSUYA YUMIOKA, HIDETO IWAMOTO, KATSUYA HIKITA, TAKEHIRO SEJIMA, MASASHI HONDA and ATSUSHI TAKENAKA

Anticancer Research July 2019, 39 (7) 3879-3885; DOI: https://doi.org/10.21873/anticanres.13538
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Initial Experience of Pembrolizumab Therapy in Japanese Patients With Metastatic Urothelial Cancer
SHOTARO YASUOKA, TAKESHI YUASA, NORIKO NISHIMURA, MASAHIRO OGAWA, YOSHINOBU KOMAI, NOBORU NUMAO, SHINYA YAMAMOTO, YUKIHIRO KONDO and JUNJI YONESE

Anticancer Research July 2019, 39 (7) 3887-3892; DOI: https://doi.org/10.21873/anticanres.13539
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Efficacy of Nilotinib in a CML Patient Expressing the Three-way Complex Variant Translocation t(2;9;22)
ELENA TIRRÒ, MICHELE MASSIMINO, STEFANIA STELLA, VALENTINA ZAMMIT, MARIA LETIZIA CONSOLI, MARIA STELLA PENNISI, SILVIA RITA VITALE, CHIARA ROMANO, MARIA CRISTINA PIROSA, ENRICA MARTINO, SANDRA DI GREGORIO, ADRIANA PUMA, FRANSCESCO DI RAIMONDO, LIVIA MANZELLA and FABIO STAGNO

Anticancer Research July 2019, 39 (7) 3893-3899; DOI: https://doi.org/10.21873/anticanres.13540
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Abiraterone Acetate and Enzalutamide: Similar Efficacy in Treating Post Docetaxel Metastatic Castration-resistant Prostate Cancer: Single Center Experience
LI-WEN CHANG, SHENG-CHUN HUNG, SHIAN-SHIANG WANG, JIAN-RI LI, CHENG-KUANG YANG, CHUAN-SHU CHEN, HAO-CHUNG HO, CHEN-LI CHENG, YEN-CHUAN OU and KUN-YUAN CHIU

Anticancer Research July 2019, 39 (7) 3901-3908; DOI: https://doi.org/10.21873/anticanres.13541
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Reduction of Intrahepatic Tumour by Hepatic Arterial Infusion Chemotherapy Prolongs Survival in Hepatocellular Carcinoma
PIL SOO SUNG, KEUNGMO YANG, SI HYUN BAE, JUNG SUK OH, HO JONG CHUN, HEE CHUL NAM, JEONG WON JANG, JONG YOUNG CHOI and SEUNG KEW YOON

Anticancer Research July 2019, 39 (7) 3909-3916; DOI: https://doi.org/10.21873/anticanres.13542
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Retreatment With Anti-PD-L1 Antibody in Advanced Non-small Cell Lung Cancer Previously Treated With Anti-PD-1 Antibodies
KOHEI FUJITA, NAOHIRO UCHIDA, YUKI YAMAMOTO, OSAMU KANAI, MISATO OKAMURA, KOICHI NAKATANI, SATORU SAWAI and TADASHI MIO

Anticancer Research July 2019, 39 (7) 3917-3921; DOI: https://doi.org/10.21873/anticanres.13543
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Which Is Better EGFR-TKI Followed by Osimertinib: Afatinib or Gefitinib/Erlotinib?
MOTOHIRO TAMIYA, AKIHIRO TAMIYA, HIDEKAZU SUZUKI, KAZUNORI MORIIZUMI, KENJI NAKAHAMA, YOSHIHIKO TANIGUCHI, KEI KUNIMASA, MADOKA KIMURA, TAKAKO INOUE, HANAKO KUHARA, KAZUMI NISHINO, TOMONORI HIRASHIMA, SHINJI ATAGI, FUMIO IMAMURA and TORU KUMAGAI

Anticancer Research July 2019, 39 (7) 3923-3929; DOI: https://doi.org/10.21873/anticanres.13544
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S-1 Monotherapy After Failure of Platinum Plus 5-Fluorouracil Chemotherapy in Recurrent or Metastatic Esophageal Carcinoma
TAKAHIKO ITO, YOSHITAKA HONMA, HIDEKAZU HIRANO, HIROKAZU SHOJI, NATSUKO OKITA, SATORU IWASA, ATSUO TAKASHIMA, KEN KATO and NARIKAZU BOKU

Anticancer Research July 2019, 39 (7) 3931-3936; DOI: https://doi.org/10.21873/anticanres.13545
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Random Allocated Study of Wrapping Oblate for Prevention of Everolimus-associated Stomatitis in Patients With Metastatic Renal Cell Carcinoma
KWONOH PARK, YOUNGAE BAEK and JAE-LYUN LEE

Anticancer Research July 2019, 39 (7) 3937-3944; DOI: https://doi.org/10.21873/anticanres.13546
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Efficacy and Toxicity of Pembrolizumab in Pediatric Metastatic Recurrent Melanoma
AGATA MARJANSKA, PRZEMYSLAW GALAZKA, MICHAL MARJANSKI, MARIUSZ WYSOCKI and JAN STYCZYNSKI

Anticancer Research July 2019, 39 (7) 3945-3947; DOI: https://doi.org/10.21873/anticanres.13547
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Efficacy of Dasatinib in a Very Elderly CML Patient Expressing a Rare E13a3 Bcr-Abl1 Fusion Transcript: A Case Report
MICHELE MASSIMINO, STEFANIA STELLA, ELENA TIRRÒ, MARIA LETIZIA CONSOLI, MARIA STELLA PENNISI, ADRIANA PUMA, SILVIA RITA VITALE, CHIARA ROMANO, VALENTINA ZAMMIT, FABIO STAGNO, FRANCESCO DI RAIMONDO and LIVIA MANZELLA

Anticancer Research July 2019, 39 (7) 3949-3954; DOI: https://doi.org/10.21873/anticanres.13548
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Panniculitis Under Successful Targeted Inhibition of the MAPK/ERK Signaling Pathway in a Patient With BRAF V600E-mutated Spindle Cell Oncocytoma of the Pituitary Gland
LUKAS SOLLFRANK, SEBASTIAN LETTMAIER, MICHAEL ERDMANN and UGUR USLU

Anticancer Research July 2019, 39 (7) 3955-3959; DOI: https://doi.org/10.21873/anticanres.13549
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Financial Toxicity and Non-small Cell Lung Cancer Treatment: The Optimization in the Choice of Immune Check Point Inhibitors
JACOPO GIULIANI and ANDREA BONETTI

Anticancer Research July 2019, 39 (7) 3961-3965; DOI: https://doi.org/10.21873/anticanres.13550
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The Onset of Grade ≥3 Neutropenia Is Associated With Longer Overall Survival in Metastatic Colorectal Cancer Patients Treated With Trifluridine/Tipiracil
JACOPO GIULIANI and ANDREA BONETTI

Anticancer Research July 2019, 39 (7) 3967-3969; DOI: https://doi.org/10.21873/anticanres.13551
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The Economic Impact of Biosimilars in Oncology and Hematology: The Case of Trastuzumab and Rituximab
JACOPO GIULIANI and ANDREA BONETTI

Anticancer Research July 2019, 39 (7) 3971-3973; DOI: https://doi.org/10.21873/anticanres.13552

Errata

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Anticancer Research July 2019, 39 (7) 3975;
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Anticancer Research July 2019, 39 (7) 3975;
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BOOK REVIEWS

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Book Reviews
Anticancer Research July 2019, 39 (7) 3977;
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Platelets. 4th Edition
Anticancer Research July 2019, 39 (7) 3977;
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Practical Guide for Biomedical Signals Analysis Using Machine Learning Techniques. 1st Edition. A MATLAB Based Approach
Anticancer Research July 2019, 39 (7) 3977;
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Malignant Pleural Mesothelioma. 1st Edition. A Guide for Clinicians
Anticancer Research July 2019, 39 (7) 3977;
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Reproducibility in Biomedical Research. 1st Edition. Epistemological and Statistical Problems
Anticancer Research July 2019, 39 (7) 3977-3978;
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Oxford Textbook of Cancer Biology
Anticancer Research July 2019, 39 (7) 3978;

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Anticancer Research July 2019, 39 (7) 3979;

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Special Issue on New Anticancer Agents

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