Hypoxia Induced by Vascular Damage at High Doses Could Compromise the Outcome of Radiotherapy

EMELY KJELLSSON LINDBLOM; ALEXANDRU DASU; IULIANA TOMA-DASU

doi:10.21873/anticanres.13350

Research ArticleExperimental Studies

Hypoxia Induced by Vascular Damage at High Doses Could Compromise the Outcome of Radiotherapy

EMELY KJELLSSON LINDBLOM, ALEXANDRU DASU and IULIANA TOMA-DASU

Anticancer Research May 2019, 39 (5) 2337-2340; DOI: https://doi.org/10.21873/anticanres.13350

EMELY KJELLSSON LINDBLOM

1Medical Radiation Physics, Department of Physics, Stockholm University, Stockholm, Sweden

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For correspondence: emely.lindblom{at}fysik.su.se

ALEXANDRU DASU

2Department of Medical and Health Sciences, Linköping University, Linköping, Sweden

3The Skandion Clinic, Uppsala, Sweden

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IULIANA TOMA-DASU

1Medical Radiation Physics, Department of Physics, Stockholm University, Stockholm, Sweden

4Department of Oncology and Pathology, Karolinska Institute, Stockholm, Sweden

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Figure 1.
Cross-sections through the simulated tumour with the larger chronically hypoxic subvolume at the beginning of the treatment (A), and with radiation-induced 35% collapsed vessels (B). The homogeneous dose distribution including a 20% boost dose is shown in (C).

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Hypoxia Induced by Vascular Damage at High Doses Could Compromise the Outcome of Radiotherapy

EMELY KJELLSSON LINDBLOM, ALEXANDRU DASU, IULIANA TOMA-DASU

Anticancer Research May 2019, 39 (5) 2337-2340; DOI: 10.21873/anticanres.13350

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Hypoxia Induced by Vascular Damage at High Doses Could Compromise the Outcome of Radiotherapy

EMELY KJELLSSON LINDBLOM, ALEXANDRU DASU, IULIANA TOMA-DASU

Anticancer Research May 2019, 39 (5) 2337-2340; DOI: 10.21873/anticanres.13350

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Keywords

hypoxia
vascular damage
stereotactic body radiotherapy
SBRT
tumour control probability
TCP
tumour oxygenation

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