Skip to main content

Main menu

  • Home
  • Current Issue
  • Archive
  • Info for
    • Authors
    • Subscribers
    • Advertisers
    • Editorial Board
  • Other Publications
    • In Vivo
    • Cancer Genomics & Proteomics
    • Cancer Diagnosis & Prognosis
  • More
    • IIAR
    • Conferences
    • 2008 Nobel Laureates
  • About Us
    • General Policy
    • Contact
  • Other Publications
    • Anticancer Research
    • In Vivo
    • Cancer Genomics & Proteomics

User menu

  • Register
  • Subscribe
  • My alerts
  • Log in
  • My Cart

Search

  • Advanced search
Anticancer Research
  • Other Publications
    • Anticancer Research
    • In Vivo
    • Cancer Genomics & Proteomics
  • Register
  • Subscribe
  • My alerts
  • Log in
  • My Cart
Anticancer Research

Advanced Search

  • Home
  • Current Issue
  • Archive
  • Info for
    • Authors
    • Subscribers
    • Advertisers
    • Editorial Board
  • Other Publications
    • In Vivo
    • Cancer Genomics & Proteomics
    • Cancer Diagnosis & Prognosis
  • More
    • IIAR
    • Conferences
    • 2008 Nobel Laureates
  • About Us
    • General Policy
    • Contact
  • Visit us on Facebook
  • Follow us on Linkedin
Research ArticleClinical Studies

A 12-year Recurrence-free Survival After Multidisciplinary Treatment for a Patient With Combined Hepatocellular–Cholangiocarcinoma

TATSUNORI MIYATA, TORU BEPPU, YU IMAMURA, HIROMITSU HAYASHI, KATSUNORI IMAI, AKIRA CHIKAMOTO, YO-ICHI YAMASHITA, KOTARO FUKUBAYASHI, TAKATOSHI ISHIKO and HIDEO BABA
Anticancer Research April 2019, 39 (4) 2139-2144; DOI: https://doi.org/10.21873/anticanres.13327
TATSUNORI MIYATA
1Department of Gastroenterological Surgery, Graduate School of Life Sciences, Kumamoto University, Kumamoto, Japan
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
TORU BEPPU
1Department of Gastroenterological Surgery, Graduate School of Life Sciences, Kumamoto University, Kumamoto, Japan
2Department of Surgery, Yamaga City Medical Center, Kumamoto, Japan
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
YU IMAMURA
1Department of Gastroenterological Surgery, Graduate School of Life Sciences, Kumamoto University, Kumamoto, Japan
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
HIROMITSU HAYASHI
1Department of Gastroenterological Surgery, Graduate School of Life Sciences, Kumamoto University, Kumamoto, Japan
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
KATSUNORI IMAI
1Department of Gastroenterological Surgery, Graduate School of Life Sciences, Kumamoto University, Kumamoto, Japan
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
AKIRA CHIKAMOTO
1Department of Gastroenterological Surgery, Graduate School of Life Sciences, Kumamoto University, Kumamoto, Japan
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
YO-ICHI YAMASHITA
1Department of Gastroenterological Surgery, Graduate School of Life Sciences, Kumamoto University, Kumamoto, Japan
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
KOTARO FUKUBAYASHI
3Department of Gastroenterology, Tamana Central Hospital, Kumamoto, Japan
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
TAKATOSHI ISHIKO
1Department of Gastroenterological Surgery, Graduate School of Life Sciences, Kumamoto University, Kumamoto, Japan
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
HIDEO BABA
1Department of Gastroenterological Surgery, Graduate School of Life Sciences, Kumamoto University, Kumamoto, Japan
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • Article
  • Figures & Data
  • Info & Metrics
  • PDF
Loading

Abstract

We report a 64-year-old woman with a 9-cm liver tumor in the left lateral section. The patient had neither hepatitis B or C virus infection, nor cirrhosis. Carbohydrate antigen 19-9 (CA 19-9) level was 1,889 U/ml. We also suspected bulky hilar lymph node metastasis, and a left lateral sectionectomy without lymph node dissection (R2) was performed. The pathological findings led to diagnosis of combined hepatocellular and cholangiocarcinoma. Three weeks post-operation, the patient underwent hepatic arterial infusion chemotherapy with cisplatin, fluorouracil, and mitomycin C. In addition, a total dose of 45 Gy of irradiation for the hilar lymph node was performed; while oral tegafur-uracil (UFT) has been administered for 10 years at a dose of 400 mg/day. The CA19-9 level of the patient was normalized after hepatectomy, hepatic arterial infusion, irradiation for hilar lymph node, and oral UFT administration. Currently, the patient is alive without any relapse for 12 years post-operation.

  • Combined hepatocellular-cholangiocarcinoma
  • multidisciplinary therapy
  • chemoradiotherapy
  • lymph-node metastasis
  • long-term survivor

Combined hepatocellular and cholangiocarcinoma (cHCC-CC) is a rare tumor, which accounts for less than 2.0% of primary liver malignancies (1, 2). cHCC-CC has pathological components of both hepatocellular carcinoma (HCC) and cholangiocarcinoma (CC); therefore, cHCC-CC has features of both diseases, including several risk factors, tumor markers, imaging features, and prognostic factors. Conversely, the prognosis of cHCC-CC appears to be worse than that of HCC and comparable to CC (2-4). The most effective treatment for cHCC-CC is surgical resection. In addition, some reports show multidisciplinary treatment using chemotherapy and radiotherapy improves prognosis in patients with cHCC-CC better than surgical resection alone (5-8).

Herein, we report an extremely rare case of cHCC-CC treated with multidisciplinary therapy, whose disease-free survival is about 12 years after hepatectomy.

Case Report

A 64-year-old woman with severe abdominal pain, who was diagnosed as having a huge liver tumor, was referred to our hospital for surgical resection. The patient had neither hepatitis B or C infection, nor cirrhosis. Laboratory tests showed that the serum levels of alpha-fetoprotein (AFP), des-gamma-carboxy prothrombin (DCP), carcinoembryonic antigen (CEA), and carbohydrate antigen 19-9 (CA 19-9) were 4.4 ng/ml, 11 mAU/ml, 1.7 ng/ml, and 1,889 U/ml, respectively. In ultrasonography, the 9-cm diameter tumor was located in the left lateral sector without invasion of the left hepatic vein or left branch of Glisson's sheath. Due to the fact that the tumor was gradually enhanced from the periphery to the inner tumor area, from the arterial to the portal vein phase on enhanced-contrast computed tomography (CT) (Figure 1A and B), and serum CA19-9 level was very high, the tumor was diagnosed preoperatively as an intrahepatic CC (ICC). Moreover, lymph node metastasis was suspected because the lymph nodes along common hepatic artery (#8) and hepatoduodenal ligament (#12) were enlarged (Figure 1C and D), and abnormal accumulation was observed in positron emission tomography.

Figure 1.
  • Download figure
  • Open in new tab
  • Download powerpoint
Figure 1.

Contrast-enhanced computed tomography images of the cHCC-CC. cHCC-CC was located in left lateral section (arrows). The tumor was gradually enhanced from the periphery to the inner tumor area, from the arterial to the portal vein phase; however, the tumor core showed no enhancement (A, B). Bulky lymph node metastasis was observed in the hepatoduodenal ligament (arrowhead) (C, D).

Regarding surgical strategy, the plan was to perform a left hepatectomy and extrahepatic bile duct resection, in case that radical resection was possible. Otherwise, we planned to perform only a left lateral sectionectomy and chemoradiotherapy (CRT) for lymph node metastasis as soon as possible after the operation. In laparotomy, there was a small amount of ascites; however, cytological diagnosis showed no malignant cells. Peritoneal dissemination was also not detected. The tumor was found on the surface of the left lateral section with greatly enlarged lymph nodes along the lesser curvature of the stomach (#3), the #8, and the #12. Intraoperative ultrasonography examination confirmed a small part of tumor invasion into the umbilical portion, and subsequently, a left lateral sectionectomy without lymph node dissection was performed (Figure 2A and B). The pathological examination revealed that the tumor contained both moderately to poorly differentiated HCC, and well to moderately differentiated CC (Figure 2C and D) with invasion of the second branch of the portal vein (vp2) and the major hepatic vein branch (vv2). No cancer cells were detected in the resection stump of the left hepatic vein. After palliative hepatectomy with macroscopic cancer remnant (R2), the patient recovered steadily and was discharged at 9 days post-operation without any complications.

The patient was re-hospitalized 3 weeks post-operation to undergo hepatic arterial infusion (HAI) chemotherapy with cisplatin (CDDP) at a dose of 75 mg, fluorouracil (5-FU) at a dose of 750 mg, and mitomycin C (MMC) at a dose of 2 mg, due to pathological findings of microvascular invasion. In addition, we performed CRT for the remaining enlarged abdominal lymph nodes after HAI as follows: a total dose of 45 Gy in 15 fractions and 400 mg/day of oral tegafur-uracil (UFT-E combination granule). After discharge from our department, blood tests were conducted once every 2 or 3 months, and CT was performed twice per year. After all, the administration of UFT-E had started as a part of CRT and continued for 10 years as maintenance chemotherapy. Serum CA19-9 levels normalized after hepatectomy, HAI chemotherapy, and CRT. Surprisingly, the patient is still alive without any relapse during the12-year follow-up period (Figure 3).

Figure 2.
  • Download figure
  • Open in new tab
  • Download powerpoint
Figure 2.

Macroscopic and pathological findings. The tumor was whitish with a clear border and bulged on the surface of the liver (A, B). Hematoxylin and eosin staining revealed characteristic microscopic features of both HCC (C) and CC (D). Scale bar=100 μm.

Discussion

cHCC-CC is a rare primary liver cancer with poor prognosis (1, 3, 4). In a study of 26 cHCC-C it was reported that the 5-year survival rate and mean survival time of them were 11.5% and 1.8 years, respectively (9). Moreover, cHCC-CC tumors were significantly more invasive to the portal vein than the HCC tumors; however, they were comparable to the CC (9). Although surgical resection is the best way to improve patient prognosis, the effectiveness of surgical resection alone is limited because of high rate of recurrence (10). High serum CA19-9 level, large tumor size, vascular invasion, lymph node metastasis, and satellite lesions are reported as poor prognostic factors in cHCC-CC following hepatectomy (11-13). Therefore, to improve patient prognosis, not only liver resection but also additional therapies should be considered for cHCC-CC patients with poor prognosis.

HAI is an effective therapy following hepatectomy in liver cancers. Nitta et al. suggested that HAI for HCC patients with vascular invasion might reduce the risk of recurrence (14). Boehm et al. also showed that HAI treatment was more effective than transcatheter arterial chemoembolization (TACE), drug-eluting bead TACE (DEB-TACE), and yttrium-90 radioembolization (Y-90) for unresectable ICC (15). Although the usefulness of HAI in cHCC-CC treatment is still unclear, based on previous reports, it should be considered as a therapeutic option following hepatectomy for advanced cHCC-CC. The present case had vascular invasion such as vp2 and vv2; therefore, we decided to perform HAI with IA call and 5-FU.

Figure 3.
  • Download figure
  • Open in new tab
  • Download powerpoint
Figure 3.

Change of CA19-9 during multidisciplinary therapy. CA19-9 rapidly decreased after hepatectomy, and further decreased after hepatic arterial infusion and irradiation. Furthermore, it is maintained within the normal range by UFT oral administration for 10 years. UFT, Tegafur-uracil; CA 19-9, carbohydrate antigen 19-9; HAI, hepatic arterial infusion; RT, radiotherapy; CDDP, cisplatin; 5-FU, fluorouracil; MMC, mitomycin.

The post-hepatectomy prognosis of cHCC-CC patients with lymph node metastasis is quite poor (13). As in CC, the effect of lymph node dissection for cHCC-CC still remains unclear (2). Because the present case also had bulky lymph node metastasis, we could easily predict a macroscopic remnant tumor after lymph node dissection. Therefore, we did not perform lymph node dissection and planed to perform local treatment with postoperative radiotherapy (RT). In fact, the efficacy of CRT in cHCC-CC with lymph node metastasis, has already been reported. Hayashi et al. presented a patient who survived 42 months disease-free after adjuvant chemotherapy (UFT) and RT following hepatectomy (6). For unresectable ICC, in a study with 2,842 patients, CRT was reported to prolong patient survival significantly longer than chemotherapy alone (16). Some studies have shown that CRT induces anticancer immunity by CD8 positive T cells in both the tumor (17) and the stroma (18). In addition, RT has been associated with a number of anti-tumor mechanisms such as (i) improved antigen cross-presentation, (ii) increased Type I interferon release, and (iii) enhanced major histocompatibility complex (MHC) class I expression on tumor cells (19, 20). Therefore, as a treatment strategy of cHCC-CC with massive lymph node metastasis like the present case, CRT after palliative hepatectomy may be considered an effective treatment option.

A standard systemic chemotherapy regimen has not yet been established for unresectable cHCC-CCs, while the effect of systemic chemotherapy remains unclear with unfavorable outcomes (21, 22). In a retrospective analysis of 7 patients, Rogers et al. showed that disease control was achieved in 3 patients who received gemcitabine plus platinum with or without bevacizumab as the first or second line of treatment (22). A recent multicenter retrospective analysis involving 36 patients showed the efficacy of platinum-containing regimens (23). These results suggest that platinum-containing regimens seem to be more effective than other available treatments. There have also been reports on the utility of UFT in advanced liver cancer (6, 7, 24). In the present case, we referred to the literature and selected UFT by oral administration. Several reports on systemic chemotherapy for cHCC-CC suggest that it can be efficacious when used alone; however, prospective trials are needed to identify a standard of care for unresectable cHCC-CCs.

In conclusion, we experienced a case of cHCC-CC with bulky hilar lymph node metastasis who survived for 12 years without relapse. The multidisciplinary treatment consists of left lateral sectionectomy and HAI for liver tumor in combination with CRT for lymph node metastasis followed by UFT administration as maintenance adjuvant chemotherapy. We suggest this treatment strategy as an option to improve prognosis in patients with advanced cHCC-CCs.

Footnotes

  • Authors' Contributions

    Conception and design: T. Miyata, T. Beppu; Acquisition of data: T. Miyata, Y. Imamura, T. Beppu; Writing, review, and/or revision of the manuscript: All authors; Supervision: Hideo Baba.

  • Compliance with Ethical Standards

    Informed consent was obtained from the patient.

  • Conflicts of Interest

    The Authors declare that they have no conflict of interest.

  • Received February 18, 2019.
  • Revision received March 20, 2019.
  • Accepted March 20, 2019.
  • Copyright© 2019, International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved

References

  1. ↵
    1. Brunt E,
    2. Aishima S,
    3. Clavien PA,
    4. Fowler K,
    5. Goodman Z,
    6. Gores G,
    7. Gouw A,
    8. Kagen A,
    9. Klimstra D,
    10. Komuta M,
    11. Kondo F,
    12. Miksad R,
    13. Nakano M,
    14. Nakanuma Y,
    15. Ng I,
    16. Paradis V,
    17. Nyun Park Y,
    18. Quaglia A,
    19. Roncalli M,
    20. Roskams T,
    21. Sakamoto M,
    22. Saxena R,
    23. Sempoux C,
    24. Sirlin C,
    25. Stueck A,
    26. Thung S,
    27. Tsui WMS,
    28. Wang XW,
    29. Wee A,
    30. Yano H,
    31. Yeh M,
    32. Zen Y,
    33. Zucman-Rossi J,
    34. Theise N,
    35. cHCC-CCA
    : Consensus terminology for primary liver carcinomas with both hepatocytic and cholangiocytic differentation. Hepatology 68: 113-126, 2018. PMID: 29360137. DOI: 10.1002/hep.29789
    OpenUrl
  2. ↵
    1. Spolverato G,
    2. Bagante F,
    3. Tsilimigras D,
    4. Ejaz A,
    5. Cloyd J,
    6. Pawlik TM
    : Management and outcomes among patients with mixed hepatocholangiocellular carcinoma: A population-based analysis. J Surg Oncol 119: 278-287, 2019. PMID: 30554420. DOI: 10.1002/jso.25331
    OpenUrl
  3. ↵
    1. Wang AQ,
    2. Zheng YC,
    3. Du J,
    4. Zhu CP,
    5. Huang HC,
    6. Wang SS,
    7. Wu LC,
    8. Wan XS,
    9. Zhang HH,
    10. Miao RY,
    11. Sang XT,
    12. Zhao HT
    : Combined hepatocellular cholangiocarcinoma: Controversies to be addressed. World J Gastroenterol 22: 4459-4465, 2016. PMID: 27182157. DOI: 10.3748/wjg.v22.i18.4459
    OpenUrl
  4. ↵
    1. Wakizaka K,
    2. Yokoo H,
    3. Kamiyama T,
    4. Ohira M,
    5. Kato K,
    6. Fujii Y,
    7. Sugiyama K,
    8. Okada N,
    9. Ohata T,
    10. Nagatsu A,
    11. Shimada S,
    12. Orimo T,
    13. Kamachi H,
    14. Taketomi A
    : Clinical and pathological features of combined hepatocellular-cholangiocarcinoma compared with other liver cancers. J Gastroenterol Hepatol 2018. PMID: 30462849. DOI: 10.1111/jgh.14547
  5. ↵
    1. Eguchi H,
    2. Nagano H,
    3. Sakon M,
    4. Miyamoto A,
    5. Kondo M,
    6. Arai I,
    7. Morimoto O,
    8. Dono K,
    9. Umeshita K,
    10. Nakamori S,
    11. Wakasa K,
    12. Monden M
    : A successful resection and long-term survival of a patient with intrahepatic recurrences of combined hepatocellular-cholangiocarcinoma: report of a case. Surg Today 32: 742-746, 2002. PMID: 12181730. DOI: 10.1007/s005950200140
    OpenUrlPubMed
  6. ↵
    1. Hayashi H,
    2. Beppu T,
    3. Ishiko T,
    4. Mizumoto T,
    5. Masuda T,
    6. Okabe K,
    7. Baba Y,
    8. Okabe H,
    9. Takamori H,
    10. Kanemitsu K,
    11. Hiroto M,
    12. Baba H
    : A 42-month disease free survival case of combined hepatocellular-cholangiocarcinoma with lymph node metastases treated with multimodal therapy. Gan To Kagaku Ryoho 33: 1941-1943, 2006. PMID: 17212153.
    OpenUrlPubMed
  7. ↵
    1. Shimizu J,
    2. Hayashi S,
    3. Dono K,
    4. Yasumoto T,
    5. Zenitani M,
    6. Munakata K,
    7. Watanabe N,
    8. Takamoto K,
    9. Kagawa Y,
    10. Hata T,
    11. Kawanishi K,
    12. Ikeda K,
    13. Fujita J,
    14. Akagi K,
    15. Kitada M,
    16. Shimano T
    : A case report of combined hepatocellular-cholangiocarcinoma whose lymph node recurrence effectively treated with UFT. Gan To Kagaku Ryoho 36: 2380-2382, 2009. PMID: 20037429.
    OpenUrlPubMed
  8. ↵
    1. Hatano H,
    2. Kobayashi S,
    3. Nagano H,
    4. Tomokuni A,
    5. Tomimaru Y,
    6. Murakami M,
    7. Marubashi S,
    8. Eguchi H,
    9. Takeda Y,
    10. Tanemura M,
    11. Wakasa K,
    12. Doki Y,
    13. Mori M
    : A case of successful multimodal treatment for combined hepatocellular and cholangiocarcinoma with portal venous tumor thrombus. Gan To Kagaku Ryoho 36: 2374-2376, 2009. PMID: 20037427.
    OpenUrlPubMed
  9. ↵
    1. Yano Y,
    2. Yamamoto J,
    3. Kosuge T,
    4. Sakamoto Y,
    5. Yamasaki S,
    6. Shimada K,
    7. Ojima H,
    8. Sakamoto M,
    9. Takayama T,
    10. Makuuchi M
    : Combined hepatocellular and cholangiocarcinoma: a clinicopathologic study of 26 resected cases. Jpn J Clin Oncol 33: 283-287, 2003. PMID: 12913082.
    OpenUrlCrossRefPubMed
  10. ↵
    1. Yoon YI,
    2. Hwang S,
    3. Lee YJ,
    4. Kim KH,
    5. Ahn CS,
    6. Moon DB,
    7. Ha TY,
    8. Song GW,
    9. Jung DH,
    10. Lee JW,
    11. Hong SM,
    12. Yu ES,
    13. Lee SG
    : Postresection outcomes of combined hepatocellular carcinoma-cholangiocarcinoma, hepatocellular carcinoma and intrahepatic cholangiocarcinoma. J Gastrointest Surg 20: 411-420, 2016. PMID: 26628072. DOI: 10.1007/s11605-015-3045-3
    OpenUrl
  11. ↵
    1. Yap AQ,
    2. Chen CL,
    3. Yong CC,
    4. Kuo FY,
    5. Wang SH,
    6. Lin CC,
    7. Liu YW,
    8. Lin TL,
    9. Li WF,
    10. Millan CA,
    11. Wang CC
    : Clinicopathological factors impact the survival outcome following the resection of combined hepatocellular carcinoma and cholangiocarcinoma. Surg Oncol 22: 55-60, 2013. PMID: 23102615. DOI: 10.1016/j.suronc.2012.09.003
    OpenUrl
    1. Lee WS,
    2. Lee KW,
    3. Heo JS,
    4. Kim SJ,
    5. Choi SH,
    6. Kim YI,
    7. Joh JW
    : Comparison of combined hepatocellular and cholangiocarcinoma with hepatocellular carcinoma and intrahepatic cholangiocarcinoma. Surg Today 36: 892-897, 2006. PMID: 16998683. DOI: 10.1007/s00595-006-3276-8
    OpenUrlCrossRefPubMed
  12. ↵
    1. Kim SH,
    2. Park YN,
    3. Lim JH,
    4. Choi GH,
    5. Choi JS,
    6. Kim KS
    : Characteristics of combined hepatocelluar-cholangiocarcinoma and comparison with intrahepatic cholangiocarcinoma. Eur J Surg Oncol 40: 976-981, 2014. PMID: 24909336. DOI: 10.1016/j.ejso.2014.04.016
    OpenUrl
  13. ↵
    1. Nitta H,
    2. Beppu T,
    3. Imai K,
    4. Hayashi H,
    5. Chikamoto A,
    6. Baba H
    : Adjuvant hepatic arterial infusion chemotherapy after hepatic resection of hepatocellular carcinoma with macroscopic vascular invasion. World J Surg 37: 1034-1042, 2013. PMID: 23435678. DOI: 10.1007/s00268-013-1957-1
    OpenUrlPubMed
  14. ↵
    1. Boehm LM,
    2. Jayakrishnan TT,
    3. Miura JT,
    4. Zacharias AJ,
    5. Johnston FM,
    6. Turaga KK,
    7. Gamblin TC
    : Comparative effectiveness of hepatic artery based therapies for unresectable intrahepatic cholangiocarcinoma. J Surg Oncol 111: 213-220, 2015. PMID: 25176325. DOI: 10.1002/jso.23781
    OpenUrlCrossRefPubMed
  15. ↵
    1. Verma V,
    2. Kusi Appiah A,
    3. Lautenschlaeger T,
    4. Adeberg S,
    5. Simone CB 2nd.,
    6. Lin C
    : Chemoradiotherapy versus chemotherapy alone for unresected intrahepatic cholangiocarcinoma: practice patterns and outcomes from the national cancer data base. J Gastrointest Oncol 9: 527-535, 2018. PMID: 29998018. DOI: 10.21037/jgo.2018.01.15
    OpenUrl
  16. ↵
    1. Murakami T,
    2. Homma Y,
    3. Matsuyama R,
    4. Mori R,
    5. Miyake K,
    6. Tanaka Y,
    7. Den K,
    8. Nagashima Y,
    9. Nakazawa M,
    10. Hiroshima Y,
    11. Ueda M,
    12. Tanaka K,
    13. Hoffman RM,
    14. Bouvet M,
    15. Endo I
    : Neoadjuvant chemoradiotherapy of pancreatic cancer induces a favorable immunogenic tumor microenvironment associated with increased major histocompatibility complex class I-related chain A/B expression. J Surg Oncol 116: 416-426, 2017. PMID: 28608409. DOI: 10.1002/jso.24681
    OpenUrl
  17. ↵
    1. Shinto E,
    2. Hase K,
    3. Hashiguchi Y,
    4. Sekizawa A,
    5. Ueno H,
    6. Shikina A,
    7. Kajiwara Y,
    8. Kobayashi H,
    9. Ishiguro M,
    10. Yamamoto J
    : CD8+ and FOXP3+ tumor-infiltrating T cells before and after chemoradiotherapy for rectal cancer. Ann Surg Oncol 21(Suppl 3): S414-421, 2014. PMID: 24566864. DOI: 10.1245/s10434-014-3584-y
    OpenUrl
  18. ↵
    1. Reits EA,
    2. Hodge JW,
    3. Herberts CA,
    4. Groothuis TA,
    5. Chakraborty M,
    6. Wansley EK,
    7. Camphausen K,
    8. Luiten RM,
    9. de Ru AH,
    10. Neijssen J,
    11. Griekspoor A,
    12. Mesman E,
    13. Verreck FA,
    14. Spits H,
    15. Schlom J,
    16. van Veelen P,
    17. Neefjes JJ
    : Radiation modulates the peptide repertoire, enhances MHC class I expression, and induces successful antitumor immunotherapy. J Exp Med 203: 1259-1271, 2006. PMID: 16636135. DOI: 10.1084/ jem.20052494
    OpenUrlAbstract/FREE Full Text
  19. ↵
    1. Burnette BC,
    2. Liang H,
    3. Lee Y,
    4. Chlewicki L,
    5. Khodarev NN,
    6. Weichselbaum RR,
    7. Fu YX,
    8. Auh SL
    : The efficacy of radiotherapy relies upon induction of type i interferon-dependent innate and adaptive immunity. Cancer Res 71: 2488-2496, 2011. PMID: 21300764. DOI: 10.1158/0008-5472.can-10-2820
    OpenUrlAbstract/FREE Full Text
  20. ↵
    1. Fowler K,
    2. Saad NE,
    3. Brunt E,
    4. Doyle MB,
    5. Amin M,
    6. Vachharajani N,
    7. Tan B,
    8. Chapman WC
    : Biphenotypic primary liver carcinomas: Assessing outcomes of hepatic directed therapy. Ann Surg Oncol 22: 4130-4137, 2015. PMID: 26293835. DOI: 10.1245/s10434-015-4774-y
    OpenUrl
  21. ↵
    1. Rogers JE,
    2. Bolonesi RM,
    3. Rashid A,
    4. Elsayes KM,
    5. Elbanan MG,
    6. Law L,
    7. Kaseb A,
    8. Shroff RT
    : Systemic therapy for unresectable, mixed hepatocellular-cholangiocarcinoma: treatment of a rare malignancy. J Gastrointest Oncol 8: 347-351, 2017. PMID: 28480073. DOI: 10.21037/jgo.2017.03.03
    OpenUrl
  22. ↵
    1. Kobayashi S,
    2. Terashima T,
    3. Shiba S,
    4. Yoshida Y,
    5. Yamada I,
    6. Iwadou S,
    7. Horiguchi S,
    8. Takahashi H,
    9. Suzuki E,
    10. Moriguchi M,
    11. Tsuji K,
    12. Otsuka T,
    13. Asagi A,
    14. Kojima Y,
    15. Takada R,
    16. Morizane C,
    17. Mizuno N,
    18. Ikeda M,
    19. Ueno M,
    20. Furuse J
    : Multicenter retrospective analysis of systemic chemotherapy for unresectable combined hepatocellular and cholangiocarcinoma. Cancer Sci 109: 2549-2557, 2018. PMID: 29856900. DOI: 10.1111/cas.13656
    OpenUrl
  23. ↵
    1. Asakura H,
    2. Ohtsuka M,
    3. Ito H,
    4. Kimura F,
    5. Ambiru S,
    6. Shimizu H,
    7. Togawa A,
    8. Yoshidome H,
    9. Kato A,
    10. Miyazaki M
    : Long-term survival after extended surgical resection of intrahepatic cholangiocarcinoma with extensive lymph node metastasis. Hepatogastroenterology 52: 722-724, 2005. PMID: 15966191.
    OpenUrlPubMed
PreviousNext
Back to top

In this issue

Anticancer Research: 39 (4)
Anticancer Research
Vol. 39, Issue 4
April 2019
  • Table of Contents
  • Table of Contents (PDF)
  • Index by author
  • Back Matter (PDF)
  • Ed Board (PDF)
  • Front Matter (PDF)
Print
Download PDF
Article Alerts
Sign In to Email Alerts with your Email Address
Email Article

Thank you for your interest in spreading the word on Anticancer Research.

NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address.

Enter multiple addresses on separate lines or separate them with commas.
A 12-year Recurrence-free Survival After Multidisciplinary Treatment for a Patient With Combined Hepatocellular–Cholangiocarcinoma
(Your Name) has sent you a message from Anticancer Research
(Your Name) thought you would like to see the Anticancer Research web site.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
1 + 6 =
Solve this simple math problem and enter the result. E.g. for 1+3, enter 4.
Citation Tools
A 12-year Recurrence-free Survival After Multidisciplinary Treatment for a Patient With Combined Hepatocellular–Cholangiocarcinoma
TATSUNORI MIYATA, TORU BEPPU, YU IMAMURA, HIROMITSU HAYASHI, KATSUNORI IMAI, AKIRA CHIKAMOTO, YO-ICHI YAMASHITA, KOTARO FUKUBAYASHI, TAKATOSHI ISHIKO, HIDEO BABA
Anticancer Research Apr 2019, 39 (4) 2139-2144; DOI: 10.21873/anticanres.13327

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
Reprints and Permissions
Share
A 12-year Recurrence-free Survival After Multidisciplinary Treatment for a Patient With Combined Hepatocellular–Cholangiocarcinoma
TATSUNORI MIYATA, TORU BEPPU, YU IMAMURA, HIROMITSU HAYASHI, KATSUNORI IMAI, AKIRA CHIKAMOTO, YO-ICHI YAMASHITA, KOTARO FUKUBAYASHI, TAKATOSHI ISHIKO, HIDEO BABA
Anticancer Research Apr 2019, 39 (4) 2139-2144; DOI: 10.21873/anticanres.13327
del.icio.us logo Digg logo Reddit logo Twitter logo CiteULike logo Facebook logo Google logo Mendeley logo
  • Tweet Widget
  • Facebook Like
  • Google Plus One

Jump to section

  • Article
    • Abstract
    • Case Report
    • Discussion
    • Footnotes
    • References
  • Figures & Data
  • Info & Metrics
  • PDF

Related Articles

  • No related articles found.
  • PubMed
  • Google Scholar

Cited By...

  • No citing articles found.
  • Google Scholar

More in this TOC Section

  • Pelvic Recurrence After Curative Resection for Rectal Adenocarcinoma: Impact of Surgery on Survival
  • Glasgow Prognostic Score Predicts Survival and Recurrence Pattern in Patients With Hepatocellular Carcinoma After Hepatectomy
  • Small Bowel Lipomatosis: An Unusual Radiological Finding in Patients With Renal Cell Cancer on Pazopanib
Show more Clinical Studies

Similar Articles

Keywords

  • Combined hepatocellular-cholangiocarcinoma
  • multidisciplinary therapy
  • chemoradiotherapy
  • lymph-node metastasis
  • long-term survivor
Anticancer Research

© 2023 Anticancer Research

Powered by HighWire