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Research ArticleClinical Studies

Combination of Distance from Superior Mesenteric Artery and Serum CA19-9 as a Novel Prediction of Local Recurrence in Patients With Pancreatic Cancer Following Resection

FUMITAKE SUZUKI, YUKI FUJIWARA, RYOGA HAMURA, KOICHIRO HARUKI, TARO SAKAMOTO, HIROAKI SHIBA and KATSUHIKO YANAGA
Anticancer Research March 2019, 39 (3) 1469-1478; DOI: https://doi.org/10.21873/anticanres.13264
FUMITAKE SUZUKI
Department of Surgery, The Jikei University School of Medicine, Tokyo, Japan
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YUKI FUJIWARA
Department of Surgery, The Jikei University School of Medicine, Tokyo, Japan
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  • For correspondence: sheetan{at}jikei.ac.jp
RYOGA HAMURA
Department of Surgery, The Jikei University School of Medicine, Tokyo, Japan
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KOICHIRO HARUKI
Department of Surgery, The Jikei University School of Medicine, Tokyo, Japan
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TARO SAKAMOTO
Department of Surgery, The Jikei University School of Medicine, Tokyo, Japan
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HIROAKI SHIBA
Department of Surgery, The Jikei University School of Medicine, Tokyo, Japan
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KATSUHIKO YANAGA
Department of Surgery, The Jikei University School of Medicine, Tokyo, Japan
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    Figure 1.

    The shortest distance from CHA to the edge of the tumor (A: under 20.55 mm, B: over 20.55 mm). The shortest distance from SMA to the edge of the tumor (C: under 10.9 mm, D: over 10.9 mm). Scale bars: Centimeters are shown in each image.

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    Figure 2.

    (A) ROC curve of distance from CHA or SMA in relation to the local recurrence after pancreatic resection. The optimal cut-off level for the distance from CHA was 20.55 mm, with an AUC of 0.617 (95%CI=0.519-0.715, p=0.025). On the other hand, the distance from SMA was 10.9 mm, with the AUC of 0.670 (95%CI=0.578-0.761, p=0.001). Relationship between distance from CHA (B) or SMA (C) and the type of recurrence.

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    Figure 3.

    Kaplan-Meier curves of local recurrence-free survival (A and C, respectively) and overall survival (B and D, respectively) in relation to CHA score and SMA score, respectively. Patients in this analysis were classified as recurrence-free and local recurrence group. Both CHA and SMA scores were negatively associated with local recurrence-free survival (p=0.004, p<0.001) and overall survival (p=0.002, p<0.001), respectively.

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Vol. 39, Issue 3
March 2019
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Combination of Distance from Superior Mesenteric Artery and Serum CA19-9 as a Novel Prediction of Local Recurrence in Patients With Pancreatic Cancer Following Resection
FUMITAKE SUZUKI, YUKI FUJIWARA, RYOGA HAMURA, KOICHIRO HARUKI, TARO SAKAMOTO, HIROAKI SHIBA, KATSUHIKO YANAGA
Anticancer Research Mar 2019, 39 (3) 1469-1478; DOI: 10.21873/anticanres.13264

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Combination of Distance from Superior Mesenteric Artery and Serum CA19-9 as a Novel Prediction of Local Recurrence in Patients With Pancreatic Cancer Following Resection
FUMITAKE SUZUKI, YUKI FUJIWARA, RYOGA HAMURA, KOICHIRO HARUKI, TARO SAKAMOTO, HIROAKI SHIBA, KATSUHIKO YANAGA
Anticancer Research Mar 2019, 39 (3) 1469-1478; DOI: 10.21873/anticanres.13264
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Keywords

  • pancreatic cancer
  • local recurrence
  • elective pancreatic resection
  • distance from SMA
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