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Research ArticleClinical Studies

Early Recurrence and Cancer Death After Trimodal Therapy for Esophageal Squamous Cell Carcinoma

YOICHI HAMAI, MANABU EMI, YUTA IBUKI, YUJI MURAKAMI, IKUNO NISHIBUCHI, YASUSHI NAGATA, TAKAOKI FURUKAWA, TOMOAKI KUROKAWA, MANATO OHSAWA and MORIHITO OKADA
Anticancer Research March 2019, 39 (3) 1433-1440; DOI: https://doi.org/10.21873/anticanres.13259
YOICHI HAMAI
1Department of Surgical Oncology, Research Institute for Radiation Biology and Medicine, Hiroshima University, Hiroshima, Japan
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  • For correspondence: yyhamai{at}hotmail.com
MANABU EMI
1Department of Surgical Oncology, Research Institute for Radiation Biology and Medicine, Hiroshima University, Hiroshima, Japan
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YUTA IBUKI
1Department of Surgical Oncology, Research Institute for Radiation Biology and Medicine, Hiroshima University, Hiroshima, Japan
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YUJI MURAKAMI
2Department of Radiation Oncology, Institute of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan
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IKUNO NISHIBUCHI
2Department of Radiation Oncology, Institute of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan
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YASUSHI NAGATA
2Department of Radiation Oncology, Institute of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan
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TAKAOKI FURUKAWA
1Department of Surgical Oncology, Research Institute for Radiation Biology and Medicine, Hiroshima University, Hiroshima, Japan
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TOMOAKI KUROKAWA
1Department of Surgical Oncology, Research Institute for Radiation Biology and Medicine, Hiroshima University, Hiroshima, Japan
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MANATO OHSAWA
1Department of Surgical Oncology, Research Institute for Radiation Biology and Medicine, Hiroshima University, Hiroshima, Japan
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MORIHITO OKADA
1Department of Surgical Oncology, Research Institute for Radiation Biology and Medicine, Hiroshima University, Hiroshima, Japan
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    Figure 1.

    Recurrence-free (RFS; left panel) and overall (OS; right panel) survival of patients with esophageal squamous cell carcinoma after trimodal therapy according to the presence of risk factors [pathological nodal staging (ypN), postoperative complications, and venous invasion] associated with early recurrence and early cancer death. A: Survival rates of patients according to ypN as a risk factor for early recurrence (p<0.0001). B: Survival rates of patients with Clavien–Dindo grade ≥3b postoperative complications with/without venous invasion compared with those with neither of them as risk factors for early cancer death (RFS: p=0.0004; OS: p=0.001).

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March 2019
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Early Recurrence and Cancer Death After Trimodal Therapy for Esophageal Squamous Cell Carcinoma
YOICHI HAMAI, MANABU EMI, YUTA IBUKI, YUJI MURAKAMI, IKUNO NISHIBUCHI, YASUSHI NAGATA, TAKAOKI FURUKAWA, TOMOAKI KUROKAWA, MANATO OHSAWA, MORIHITO OKADA
Anticancer Research Mar 2019, 39 (3) 1433-1440; DOI: 10.21873/anticanres.13259

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Early Recurrence and Cancer Death After Trimodal Therapy for Esophageal Squamous Cell Carcinoma
YOICHI HAMAI, MANABU EMI, YUTA IBUKI, YUJI MURAKAMI, IKUNO NISHIBUCHI, YASUSHI NAGATA, TAKAOKI FURUKAWA, TOMOAKI KUROKAWA, MANATO OHSAWA, MORIHITO OKADA
Anticancer Research Mar 2019, 39 (3) 1433-1440; DOI: 10.21873/anticanres.13259
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  • Correlation Between Tumor Uptake on FDG-PET and Malignant Features in Esophageal Squamous Cell Carcinoma After Neoadjuvant Chemotherapy Followed by Surgery
  • Neutrophil-to-Lymphocyte Ratio as a Predictor of Postoperative Recurrence and Prognosis in Oesophageal Squamous Cell Carcinoma
  • Comparison of Open and Thoracoscopic Esophagectomy in Patients With Locally Advanced Esophageal Squamous Cell Carcinoma After Neoadjuvant Therapy
  • Risk Factors for Recurrence in Esophageal Squamous Cell Carcinoma Without Pathological Complete Response After Trimodal Therapy
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Keywords

  • chemoradiation
  • Complication
  • esophagus
  • lymph node
  • vascular invasion
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