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Research ArticleClinical Studies

Early Metabolic Response as a Predictor of Treatment Outcome in Patients With Metastatic Soft Tissue Sarcomas

MYRELLA VLENTERIE, WIM JG OYEN, NEELTJE STEEGHS, INGRID M.E. DESAR, REMY B. VERHEIJEN, ANNE MIEK KOENEN, WILLEM GROOTJANS, LIOE-FEE DE GEUS-OEI, NIELKA P. VAN ERP and WINETTE TA VAN DER GRAAF
Anticancer Research March 2019, 39 (3) 1309-1316; DOI: https://doi.org/10.21873/anticanres.13243
MYRELLA VLENTERIE
1Department of Medical Oncology, Radboud University Medical Center, Nijmegen, the Netherlands
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  • For correspondence: myrella.vlenterie{at}radboudumc.nl
WIM JG OYEN
2Department of Radiology and Nuclear Medicine, Radboud University Medical Center, Nijmegen, the Netherlands
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NEELTJE STEEGHS
3Department of Medical Oncology, Antoni van Leeuwenhoek – Netherlands Cancer Institute, Amsterdam, the Netherlands
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INGRID M.E. DESAR
1Department of Medical Oncology, Radboud University Medical Center, Nijmegen, the Netherlands
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REMY B. VERHEIJEN
4Department of Pharmacy, Antoni van Leeuwenhoek – Netherlands Cancer Institute, Amsterdam, the Netherlands
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ANNE MIEK KOENEN
3Department of Medical Oncology, Antoni van Leeuwenhoek – Netherlands Cancer Institute, Amsterdam, the Netherlands
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WILLEM GROOTJANS
5Department of Radiology, Leiden University Medical Center, Leiden, the Netherlands
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LIOE-FEE DE GEUS-OEI
2Department of Radiology and Nuclear Medicine, Radboud University Medical Center, Nijmegen, the Netherlands
5Department of Radiology, Leiden University Medical Center, Leiden, the Netherlands
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NIELKA P. VAN ERP
6Department of Pharmacy, Radboud University Medical Center, Nijmegen, the Netherlands
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WINETTE TA VAN DER GRAAF
1Department of Medical Oncology, Radboud University Medical Center, Nijmegen, the Netherlands
3Department of Medical Oncology, Antoni van Leeuwenhoek – Netherlands Cancer Institute, Amsterdam, the Netherlands
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    Figure 1.

    Study design. A: Study protocol timeline; a baseline FDG-PET/CT was performed 0-2 weeks before start of pazopanib therapy. B: study profile.

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    Figure 2.

    FDG-response monitoring.

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    Figure 3.

    FDG-PET response compared to clinical outcome. All patients who showed any degree of increase in metabolic activity (n=10, 0.25% - 46.47%) at two weeks, excluding the two who stopped prematurely due to toxicity, were radiologically confirmed as non-responders after eight weeks of therapy.

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    Figure 4.

    Geometric mean of the ΔSUL per metastatic site at FDG-PET at two weeks versus baseline. Of the eight patients with bone lesions five were non-responders, one patient responded to pazopanib treatment, and two patients discontinued pazopanib prematurely due to toxicity.

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    Figure 5.

    Association between pazopanib pharmacokinetics and response at eight weeks.

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Anticancer Research
Vol. 39, Issue 3
March 2019
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Early Metabolic Response as a Predictor of Treatment Outcome in Patients With Metastatic Soft Tissue Sarcomas
MYRELLA VLENTERIE, WIM JG OYEN, NEELTJE STEEGHS, INGRID M.E. DESAR, REMY B. VERHEIJEN, ANNE MIEK KOENEN, WILLEM GROOTJANS, LIOE-FEE DE GEUS-OEI, NIELKA P. VAN ERP, WINETTE TA VAN DER GRAAF
Anticancer Research Mar 2019, 39 (3) 1309-1316; DOI: 10.21873/anticanres.13243

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Early Metabolic Response as a Predictor of Treatment Outcome in Patients With Metastatic Soft Tissue Sarcomas
MYRELLA VLENTERIE, WIM JG OYEN, NEELTJE STEEGHS, INGRID M.E. DESAR, REMY B. VERHEIJEN, ANNE MIEK KOENEN, WILLEM GROOTJANS, LIOE-FEE DE GEUS-OEI, NIELKA P. VAN ERP, WINETTE TA VAN DER GRAAF
Anticancer Research Mar 2019, 39 (3) 1309-1316; DOI: 10.21873/anticanres.13243
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Keywords

  • Sarcoma
  • Soft tissue
  • positron-emission tomography
  • pharmacokinetics
  • Pazopanib
  • pharmacodynamics
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