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Research ArticleExperimental Studies

Intense Uptake of Liposomal Curcumin by Multiple Myeloma Cell Lines: Comparison to Normal Lymphocytes, Red Blood Cells and Chronic Lymphocytic Leukemia Cells

GORDON T. BOLGER, ALBERT LICOLLARI, RICHARD BAGSHAW, AIMIN TAN, RICHARD GREIL, BRIGITTA VCELAR, MUHAMMED MAJEED and PETER SORDILLO
Anticancer Research March 2019, 39 (3) 1161-1168; DOI: https://doi.org/10.21873/anticanres.13225
GORDON T. BOLGER
1Nucro-Technics, Scarborough, ON, Canada
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  • For correspondence: psordillo@signpathpharma.com bolger@nucro-technics.com
ALBERT LICOLLARI
1Nucro-Technics, Scarborough, ON, Canada
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RICHARD BAGSHAW
1Nucro-Technics, Scarborough, ON, Canada
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AIMIN TAN
1Nucro-Technics, Scarborough, ON, Canada
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RICHARD GREIL
2Third Medical Department with Hematology and Medical Oncology, Oncologic Center Salzburg Cancer Research, Paracelsus Medical University, Institute, Cancer Cluster, Salzburg, Austria
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BRIGITTA VCELAR
3Polymun Scientific Immunbiologische Forschung GmbH, Klosterneuburg, Austria
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MUHAMMED MAJEED
4Sabinsa Corporation, East Windsor, NJ, U.S.A.
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PETER SORDILLO
5SignPath Pharma Inc., New York, NY, U.S.A.
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  • For correspondence: psordillo@signpathpharma.com bolger@nucro-technics.com
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    Figure 1.

    Chemical structures of curcumin and tetrahydrocurcumin (THC).

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    Figure 2.

    Comparative cell levels of curcumin in different human blood cell types, including red blood cells (RBCs), peripheral blood mononuclear cells (PBMCs) from healthy individuals, and PBMCs from patients with chronic lymphocytic leukemia (CLL cells). The data for RBCs were taken from previously published data (22). In panel B, for RBC the mean curcumin level was 19±5 pg/106 cells. The data are presented as the mean±SE of the determinations shown in Tables I and II.

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Anticancer Research: 39 (3)
Anticancer Research
Vol. 39, Issue 3
March 2019
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Intense Uptake of Liposomal Curcumin by Multiple Myeloma Cell Lines: Comparison to Normal Lymphocytes, Red Blood Cells and Chronic Lymphocytic Leukemia Cells
GORDON T. BOLGER, ALBERT LICOLLARI, RICHARD BAGSHAW, AIMIN TAN, RICHARD GREIL, BRIGITTA VCELAR, MUHAMMED MAJEED, PETER SORDILLO
Anticancer Research Mar 2019, 39 (3) 1161-1168; DOI: 10.21873/anticanres.13225

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Intense Uptake of Liposomal Curcumin by Multiple Myeloma Cell Lines: Comparison to Normal Lymphocytes, Red Blood Cells and Chronic Lymphocytic Leukemia Cells
GORDON T. BOLGER, ALBERT LICOLLARI, RICHARD BAGSHAW, AIMIN TAN, RICHARD GREIL, BRIGITTA VCELAR, MUHAMMED MAJEED, PETER SORDILLO
Anticancer Research Mar 2019, 39 (3) 1161-1168; DOI: 10.21873/anticanres.13225
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Keywords

  • Curcumin
  • tetrahydrocurcumin
  • B-lymphocytes
  • peripheral blood mononuclear cells
  • distribution
  • metabolism
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