Article Figures & Data
Figures
- Figure 1.
Effects of pharmacological dose of vitamin C on human breast cancer cell lines. High-dose vitamin C suppressed proliferation of breast cancer cell lines (MDA-MB-231, MCF-7, and SK-BR3), but not normal cells (MCF10A).
- Figure 2.
High-dose vitamin C induces apoptosis of breast cancer cells. *p<0.01; ***p<0.001.
- Figure 3.
Combination of high-dose vitamin C and anti-cancer drugs has an additional inhibitory effect on growth of breast cancer cell lines. After treatment with eribulin mesylate for 24 h, the cells were exposed once (A, C) or twice (B, D) to various concentrations of vitamin C (5, 10, and 20 mM).
- Figure 4.
Combination effect of vitamin C with tamoxifen in MCF-7. After treatment with tamoxifen for 24 h, the cells were exposed once (A) or twice (B) to various concentrations of vitamin C (5, 10, and 20 mM). The relative cell viability of MCF-7 was significantly decreased when combining tamoxifen and two treatments of vitamin C in a dose-dependent manner for vitamin C (B).
- Figure 5.
Combination effect of vitamin C with fulvestrant in MCF-7. After treatment with fulvestrabt for 24 h, the cells were exposed once (A) or twice (B) to various concentrations of vitamin C (5, 10, and 20 mM). An additive anti-proliferative effect was observed with one treatment of vitamin C (A), yet not two (B).
- Figure 6.
Combination effect of vitamin C with trastuzumab in SK-BR3. The relative cell viability of SK-BR3 was significantly decreased when combining trastuzumab and one (A) or two (B) treatments of vitamin C without a dose-dependent effect.
- Figure 7.
High-dose vitamin C mediated an anti-proliferative effect on various anti-cancer-drug-resistant cells (tamoxifen-resistant (TAM-R) MCF-7, LTED MCF-7, docetaxel-resistant (Tax-R) MCF-7 and MDA-MB-231, and doxorubicin-resistant (Dox-R) MCF-7 and MDA-MB-231 cells. (A) High-dose vitamin C significantly inhibited the cell growth of TAM-R, Dox-R MCF-7 and LTED MCF-7 as effectively as MCF-7; (B) Anti-proliferative effects of high-dose vitamin C were also observed in Dox-R MDA-MB-231 and Tax-R MDA-MB-231, as effectively as in MDA-MB-231.
- Figure 8.
Catalase activity in breast cancer cells showed a reduction compared to MCF10A cells. The catalase activity of TAM-R MCF-7, LTED MCF-7, docetaxel-resistant MCF-7 and MDA-MB-231, and doxorubicin-resistant MCF-7 was significantly lowered compared to that of MCF10A. *p<0.01.
