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Research ArticleExperimental Studies

Bis(4-hydroxy-2H-chromen-2-one) Coumarin Induces Apoptosis in MCF-7 Human Breast Cancer Cells Through Aromatase Inhibition

LAMIA HAMDAN RAMDANI, OUALID TALHI, CAROLINE DECOMBAT, MARION VERMERIE, ALEXANDRE BERRY, ARTUR SILVA, KHALDOUN BACHARI, MARIE-PAULE VASSON, LAETITIA DELORT and FLORENCE CALDEFIE-CHÉZET
Anticancer Research November 2019, 39 (11) 6107-6114; DOI: https://doi.org/10.21873/anticanres.13818
LAMIA HAMDAN RAMDANI
1Scientific and Technical Research Center in Physico-Chemical Analysis (CRAPC), Tipaza, Algeria
2Clermont Auvergne University, INRA, UNH, Human Nutrition unit, CRNH Auvergne, Clermont Ferrand, France
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  • For correspondence: lamia_pharm{at}yahoo.fr
OUALID TALHI
1Scientific and Technical Research Center in Physico-Chemical Analysis (CRAPC), Tipaza, Algeria
3Organic Chemistry, Natural Products and Agrifood (QOPNA), Department of Chemistry & QOPNA, University of Aveiro, Aveiro, Portugal
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CAROLINE DECOMBAT
2Clermont Auvergne University, INRA, UNH, Human Nutrition unit, CRNH Auvergne, Clermont Ferrand, France
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MARION VERMERIE
2Clermont Auvergne University, INRA, UNH, Human Nutrition unit, CRNH Auvergne, Clermont Ferrand, France
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ALEXANDRE BERRY
2Clermont Auvergne University, INRA, UNH, Human Nutrition unit, CRNH Auvergne, Clermont Ferrand, France
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ARTUR SILVA
3Organic Chemistry, Natural Products and Agrifood (QOPNA), Department of Chemistry & QOPNA, University of Aveiro, Aveiro, Portugal
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KHALDOUN BACHARI
1Scientific and Technical Research Center in Physico-Chemical Analysis (CRAPC), Tipaza, Algeria
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MARIE-PAULE VASSON
2Clermont Auvergne University, INRA, UNH, Human Nutrition unit, CRNH Auvergne, Clermont Ferrand, France
4Anticancer Center Jean-Perrin, Clermont Ferrand, France
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LAETITIA DELORT
2Clermont Auvergne University, INRA, UNH, Human Nutrition unit, CRNH Auvergne, Clermont Ferrand, France
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FLORENCE CALDEFIE-CHÉZET
2Clermont Auvergne University, INRA, UNH, Human Nutrition unit, CRNH Auvergne, Clermont Ferrand, France
5CLARA, Lyon Auvergne Rhone Alpes canceropole, Lyon, France
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Article Information

vol. 39 no. 11 6107-6114
DOI 
https://doi.org/10.21873/anticanres.13818
PMID 
31704838

Published By 
International Institute of Anticancer Research
Print ISSN 
0250-7005
Online ISSN 
1791-7530
History 
  • Received September 10, 2019
  • Revision received October 11, 2019
  • Accepted October 16, 2019
  • Published online November 8, 2019.

Copyright & Usage 
Copyright© 2019, International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved

Author Information

  1. LAMIA HAMDAN RAMDANI1,2⇑,
  2. OUALID TALHI1,3,
  3. CAROLINE DECOMBAT2,
  4. MARION VERMERIE2,
  5. ALEXANDRE BERRY2,
  6. ARTUR SILVA3,
  7. KHALDOUN BACHARI1,
  8. MARIE-PAULE VASSON2,4,
  9. LAETITIA DELORT2,* and
  10. FLORENCE CALDEFIE-CHÉZET2,5,*
  1. 1Scientific and Technical Research Center in Physico-Chemical Analysis (CRAPC), Tipaza, Algeria
  2. 2Clermont Auvergne University, INRA, UNH, Human Nutrition unit, CRNH Auvergne, Clermont Ferrand, France
  3. 3Organic Chemistry, Natural Products and Agrifood (QOPNA), Department of Chemistry & QOPNA, University of Aveiro, Aveiro, Portugal
  4. 4Anticancer Center Jean-Perrin, Clermont Ferrand, France
  5. 5CLARA, Lyon Auvergne Rhone Alpes canceropole, Lyon, France
  1. Correspondence to: Lamia Hamdan Ramdani, Clermont Auvergne University, INRA, UNH, Human Nutrition Unit, CRNH Auvergne, F-63000 Clermont-Ferrand, France. Tel: +213 799423134, e-mail: lamia_pharm{at}yahoo.fr
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Bis(4-hydroxy-2H-chromen-2-one) Coumarin Induces Apoptosis in MCF-7 Human Breast Cancer Cells Through Aromatase Inhibition
LAMIA HAMDAN RAMDANI, OUALID TALHI, CAROLINE DECOMBAT, MARION VERMERIE, ALEXANDRE BERRY, ARTUR SILVA, KHALDOUN BACHARI, MARIE-PAULE VASSON, LAETITIA DELORT, FLORENCE CALDEFIE-CHÉZET
Anticancer Research Nov 2019, 39 (11) 6107-6114; DOI: 10.21873/anticanres.13818

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Bis(4-hydroxy-2H-chromen-2-one) Coumarin Induces Apoptosis in MCF-7 Human Breast Cancer Cells Through Aromatase Inhibition
LAMIA HAMDAN RAMDANI, OUALID TALHI, CAROLINE DECOMBAT, MARION VERMERIE, ALEXANDRE BERRY, ARTUR SILVA, KHALDOUN BACHARI, MARIE-PAULE VASSON, LAETITIA DELORT, FLORENCE CALDEFIE-CHÉZET
Anticancer Research Nov 2019, 39 (11) 6107-6114; DOI: 10.21873/anticanres.13818
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Keywords

  • Coumarin derivative
  • Bis(4-hydroxy-2H-chromen-2-one)
  • breast cancer
  • cell proliferation
  • cell cycle
  • apoptosis
  • aromatase inhibition
  • MCF-7 breast cancer cells
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