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Research ArticleExperimental Studies

Prothrombin 3’end Gene Variants in Patients With Sporadic Colon Adenocarcinoma

MARIJA CUMBO, BRANKO TOMIC, SOFIJA DUNJIC, TAMARA JOVANOVIC, MAJA GVOZDENOV, IVA PRUNER, GORANA ARALICA, SANJA KAPITANOVIC, TAMARA CACEV and VALENTINA DJORDJEVIC
Anticancer Research November 2019, 39 (11) 6067-6071; DOI: https://doi.org/10.21873/anticanres.13814
MARIJA CUMBO
1Institute of Molecular Genetics and Genetic Engineering, University of Belgrade, Belgrade, Serbia
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  • For correspondence: marijacumbo@imgge.bg.ac.rs
BRANKO TOMIC
1Institute of Molecular Genetics and Genetic Engineering, University of Belgrade, Belgrade, Serbia
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SOFIJA DUNJIC
1Institute of Molecular Genetics and Genetic Engineering, University of Belgrade, Belgrade, Serbia
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TAMARA JOVANOVIC
1Institute of Molecular Genetics and Genetic Engineering, University of Belgrade, Belgrade, Serbia
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MAJA GVOZDENOV
1Institute of Molecular Genetics and Genetic Engineering, University of Belgrade, Belgrade, Serbia
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IVA PRUNER
1Institute of Molecular Genetics and Genetic Engineering, University of Belgrade, Belgrade, Serbia
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GORANA ARALICA
2University Hospital Dubrava, Zagreb, Croatia
3Medical School University of Zagreb, Zagreb, Croatia
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SANJA KAPITANOVIC
4Rudjer Boskovic Institute, Zagreb, Croatia
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TAMARA CACEV
4Rudjer Boskovic Institute, Zagreb, Croatia
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VALENTINA DJORDJEVIC
1Institute of Molecular Genetics and Genetic Engineering, University of Belgrade, Belgrade, Serbia
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Abstract

Background/Aim: Thrombin plays significant roles in various types of cancer. However, the expression levels of prothrombin, the thrombin precursor, in cancer remain unclear. Variants of the 3’end of the prothrombin gene lead to increased prothrombin expression. This study aimed to analyze prothrombin 3’end gene variants in colon tumor and adjacent normal tissue samples. Materials and Methods: The study group consisted of 93 patients suffering from colon adenocarcinoma. The 3’end of the prothrombin gene was analyzed by DNA sequencing. Results: Three variants, all previously associated with increased prothrombin expression were detected. Frequency of the FII 19911G allele was 46.77% and 47.85% in tumor and normal tissue, respectively. For the FII 20210A allele, the detected frequencies were 2.15% and 1.61%, respectively. The frequency of the FII c.1824T allele was 0.54% in both tissues. Four patients showed different genotypes in tumor and normal tissue. Conclusion: Prothrombin 3’ end gene variants may play a role in colorectal cancer.

  • Colon adenocarcinoma
  • normal adjacent tissue
  • prothrombin
  • tumor
  • 3’end gene variants
  • Received September 18, 2019.
  • Revision received October 7, 2019.
  • Accepted October 8, 2019.
  • Copyright© 2019, International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved
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Anticancer Research: 39 (11)
Anticancer Research
Vol. 39, Issue 11
November 2019
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Prothrombin 3’end Gene Variants in Patients With Sporadic Colon Adenocarcinoma
MARIJA CUMBO, BRANKO TOMIC, SOFIJA DUNJIC, TAMARA JOVANOVIC, MAJA GVOZDENOV, IVA PRUNER, GORANA ARALICA, SANJA KAPITANOVIC, TAMARA CACEV, VALENTINA DJORDJEVIC
Anticancer Research Nov 2019, 39 (11) 6067-6071; DOI: 10.21873/anticanres.13814

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Prothrombin 3’end Gene Variants in Patients With Sporadic Colon Adenocarcinoma
MARIJA CUMBO, BRANKO TOMIC, SOFIJA DUNJIC, TAMARA JOVANOVIC, MAJA GVOZDENOV, IVA PRUNER, GORANA ARALICA, SANJA KAPITANOVIC, TAMARA CACEV, VALENTINA DJORDJEVIC
Anticancer Research Nov 2019, 39 (11) 6067-6071; DOI: 10.21873/anticanres.13814
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Keywords

  • colon adenocarcinoma
  • normal adjacent tissue
  • prothrombin
  • tumor
  • 3’end gene variants
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