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Research ArticleExperimental Studies

Aurora-A/NF-ĸB Signaling Is Associated With Radio-resistance in Human Lung Adenocarcinoma

JUN-BAO LIU, LIANG HU, ZHIJIAN YANG, YU SUN, ROBERT M. HOFFMAN and ZHANG YI
Anticancer Research November 2019, 39 (11) 5991-5998; DOI: https://doi.org/10.21873/anticanres.13804
JUN-BAO LIU
1Traditional Chinese Medicine Department, People's Hospital of Henan Province, People's Hospital of Zhengzhou University, Zhengzhou, P.R. China
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LIANG HU
2Department of General Surgery, The Second Hospital of Nanjing, Nanjing University of Chinese Medicine, Nanjing, P.R. China
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ZHIJIAN YANG
3AntiCancer Inc., San Diego, CA, U.S.A.
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YU SUN
3AntiCancer Inc., San Diego, CA, U.S.A.
4Department of Surgery, University of California, San Diego, CA, U.S.A.
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ROBERT M. HOFFMAN
3AntiCancer Inc., San Diego, CA, U.S.A.
4Department of Surgery, University of California, San Diego, CA, U.S.A.
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ZHANG YI
5Department of Oncology, Jimin Hospital, Shanghai, P.R. China
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  • For correspondence: m15021713798@163.com
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Abstract

Background/Aim: This study aimed to discuss the effect and possible molecular mechanisms of Aurora-A/NF-ĸB signaling on the radiotherapy resistance of human docetaxel-resistant lung adenocarcinoma cells. Materials and Methods: The human lung adenocarcinoma SPC-A1 and SPC-A1/DTX cell lines were utilized in the present study. The MTT assay measured the sensitivity of cells to radiotherapy. The tumor-initiating ability of the cells was detected in vitro by cloning assays. Apoptosis was quantified by flow cytometry. Real-time quantitative PCR and western blotting were used to detect the mRNA and protein expression of the Aurora-A/NF-ĸB, respectively. Tumors transplanted subcutaneously into nude mice were used to test the effect of Aurora-A on the in vivo sensitivity of the tumors to radiotherapy. Results: The SPC-A1/DTX docetaxel-resistant lung adenocarcinoma cells were radio-resistant compared with the parental SPC-A1 cells. Up-regulated aurora-A was responsible for the in vitro radio-resistance of docetaxel-resistant SPC-A1/DTX cells. Nuclear transcription factor NF-ĸB was identified as a downstream target gene of Aurora-A in SPC-A1/DTX cells, and NF-ĸB also participated in the radio-resistance of SPC-A1/DTX cells regulated by Aurora-A. Conclusion: The Aurora-A/NF-ĸB pathway is association with radio-resistance of human lung adenocarcinoma docetaxel-resistant cells.

  • Aurora-A
  • NF-ĸB
  • lung adenocarcinoma
  • radiotherapy
  • Received September 23, 2019.
  • Revision received October 18, 2019.
  • Accepted October 24, 2019.
  • Copyright© 2019, International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved
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Anticancer Research: 39 (11)
Anticancer Research
Vol. 39, Issue 11
November 2019
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Aurora-A/NF-ĸB Signaling Is Associated With Radio-resistance in Human Lung Adenocarcinoma
JUN-BAO LIU, LIANG HU, ZHIJIAN YANG, YU SUN, ROBERT M. HOFFMAN, ZHANG YI
Anticancer Research Nov 2019, 39 (11) 5991-5998; DOI: 10.21873/anticanres.13804

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Aurora-A/NF-ĸB Signaling Is Associated With Radio-resistance in Human Lung Adenocarcinoma
JUN-BAO LIU, LIANG HU, ZHIJIAN YANG, YU SUN, ROBERT M. HOFFMAN, ZHANG YI
Anticancer Research Nov 2019, 39 (11) 5991-5998; DOI: 10.21873/anticanres.13804
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Keywords

  • Aurora-A
  • NF-ĸB
  • Lung adenocarcinoma
  • radiotherapy
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