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Case ReportClinical Studies

Concomitant Treatment of Malignant Brain Tumours With CBD – A Case Series and Review of the Literature

RUDOLF LIKAR, MARKUS KOESTENBERGER, MARTIN STULTSCHNIG and GERHARD NAHLER
Anticancer Research October 2019, 39 (10) 5797-5801; DOI: https://doi.org/10.21873/anticanres.13783
RUDOLF LIKAR
1Department of Anaesthesiology and Intensive Care, Klinikum Klagenfurt am Wörthersee, Klagenfurt am Wörthersee, Austria
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MARKUS KOESTENBERGER
1Department of Anaesthesiology and Intensive Care, Klinikum Klagenfurt am Wörthersee, Klagenfurt am Wörthersee, Austria
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MARTIN STULTSCHNIG
2Neurological Department, Klinikum Klagenfurt am Wörthersee, Klagenfurt am Wörthersee, Austria
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GERHARD NAHLER
3CIS Clinical Investigation Support GmbH, Vienna, Austria
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  • For correspondence: nahler@aon.at
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Abstract

Grade IV glioblastoma multiforme is a deadly disease, with a median survival of around 14 to 16 months. Maximal resection followed by adjuvant radiochemotherapy has been the mainstay of treatment since many years, although survival is only extended by a few months. In recent years, an increasing number of data from in vitro and in vivo research with cannabinoids, particularly with the non-intoxicating cannabidiol (CBD), point to their potential role as tumour-inhibiting agents. Herein, a total of nine consecutive patients with brain tumours are described as case series; all patients received CBD in a daily dose of 400 mg concomitantly to the standard therapeutic procedure of maximal resection followed by radiochemotherapy. By the time of the submission of this article, all but one patient are still alive with a mean survival time of 22.3 months (range=7-47 months). This is longer than what would have been expected.

  • Cannabidiol
  • cannabinoids
  • chemoradiation
  • brain tumours
  • glioblastoma multiforme
  • Received September 5, 2019.
  • Revision received September 17, 2019.
  • Accepted September 18, 2019.
  • Copyright© 2019, International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved
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Anticancer Research: 39 (10)
Anticancer Research
Vol. 39, Issue 10
October 2019
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Concomitant Treatment of Malignant Brain Tumours With CBD – A Case Series and Review of the Literature
RUDOLF LIKAR, MARKUS KOESTENBERGER, MARTIN STULTSCHNIG, GERHARD NAHLER
Anticancer Research Oct 2019, 39 (10) 5797-5801; DOI: 10.21873/anticanres.13783

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Concomitant Treatment of Malignant Brain Tumours With CBD – A Case Series and Review of the Literature
RUDOLF LIKAR, MARKUS KOESTENBERGER, MARTIN STULTSCHNIG, GERHARD NAHLER
Anticancer Research Oct 2019, 39 (10) 5797-5801; DOI: 10.21873/anticanres.13783
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Keywords

  • cannabidiol
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  • chemoradiation
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