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Research ArticleClinical Studies

Positive Association of Male Overactive Bladder Symptoms and Androgen Deprivation: A Nationwide Population-based Cohort Study

JIAN-RI LI, SHIAN-SHIANG WANG, CHING-HENG LIN, WILLIAM C. DE GROAT and CHEN-LI CHENG
Anticancer Research January 2019, 39 (1) 305-311; DOI: https://doi.org/10.21873/anticanres.13112
JIAN-RI LI
1Division of Urology, Department of Surgery, Taichung Veterans General Hospital, Taichung, Taiwan, R.O.C.
2Institute of Medicine, Chung Shan Medical University, Taichung, Taiwan, R.O.C.
3Department of Medicine and Nursing, Hungkuang University, Taichung, Taiwan, R.O.C.
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SHIAN-SHIANG WANG
1Division of Urology, Department of Surgery, Taichung Veterans General Hospital, Taichung, Taiwan, R.O.C.
2Institute of Medicine, Chung Shan Medical University, Taichung, Taiwan, R.O.C.
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CHING-HENG LIN
4Department of Medical Research, Taichung Veterans General Hospital, Taichung, Taiwan, R.O.C.
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WILLIAM C. DE GROAT
5Department of Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA, U.S.A.
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CHEN-LI CHENG
1Division of Urology, Department of Surgery, Taichung Veterans General Hospital, Taichung, Taiwan, R.O.C.
2Institute of Medicine, Chung Shan Medical University, Taichung, Taiwan, R.O.C.
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  • For correspondence: Cheng20011@gmail.com
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Abstract

Background/Aim: The role of androgen in the modulation of voiding function is still uncertain. The aim of this study was to evaluate the association of androgen deprivation therapy (ADT) and overactive bladder (OAB) in men in a population-based cohort. Materials and Methods: This study examined the records of newly-diagnosed prostate cancer subjects receiving ADT only in the Taiwan National Health Insurance Research Database in the years between 2001 and 2007. As controls men without cancer were selected and divided into three groups, 1) benign prostate hyperplasia treated with an alpha-blocker (BPH-alpha blocker), 2) BPH treated with a 5-alpha reductase inhibitor (BPH-5ARI) and 3) healthy controls. OAB events were censored by definition of drug prescriptions for more than one month and risk analysis among each group was performed. Results: The healthy control group had decreased risk of OAB compared to the prostate cancer group and the BPH-5ARI group showed a higher risk of OAB than the prostate cancer group. Subgroup analysis showed that independently of age or comorbidities, the prevalence of OAB was significantly lower in the healthy control group. Moreover, the cumulative incidence of OAB showed a time-dependent pattern with a significant increase after ADT for 5 years. Conclusion: Androgen deprivation in prostate cancer patients was associated with an increased risk of OAB that was treatment duration-dependent. This result is consistent with an inhibitory role of androgen in the modulation of male voiding function.

  • Androgen
  • benign prostate hyperplasia
  • overactive bladder
  • prostate cancer
  • Received October 8, 2018.
  • Revision received November 21, 2018.
  • Accepted November 22, 2018.
  • Copyright© 2019, International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved
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Anticancer Research: 39 (1)
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January 2019
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Positive Association of Male Overactive Bladder Symptoms and Androgen Deprivation: A Nationwide Population-based Cohort Study
JIAN-RI LI, SHIAN-SHIANG WANG, CHING-HENG LIN, WILLIAM C. DE GROAT, CHEN-LI CHENG
Anticancer Research Jan 2019, 39 (1) 305-311; DOI: 10.21873/anticanres.13112

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Positive Association of Male Overactive Bladder Symptoms and Androgen Deprivation: A Nationwide Population-based Cohort Study
JIAN-RI LI, SHIAN-SHIANG WANG, CHING-HENG LIN, WILLIAM C. DE GROAT, CHEN-LI CHENG
Anticancer Research Jan 2019, 39 (1) 305-311; DOI: 10.21873/anticanres.13112
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Keywords

  • Androgen
  • benign prostate hyperplasia
  • overactive bladder
  • prostate cancer
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