Table of Contents

Clinical Studies

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  A Phase II Study Alternating Erlotinib With Second-line mFOLFOX6 or FOLFIRI for Metastatic Colorectal Cancer

  MATTHEW R. KEARNEY, EMERSON Y. CHEN, GINA M. VACCARO, JOHN STROTHER, ANDREA BURT, KENDRA TODD, JEFF DONOVAN, KERSTIN M. KAMPA-SCHITTENHELM and CHARLES D. LOPEZ

  Anticancer Research January 2019, 39 (1) 245-252; DOI: https://doi.org/10.21873/anticanres.13104
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  Cutaneous T-Cell Lymphoma: Trends in Radiation Doses and Patterns of Care 2004-2015

  JOSEPH A. MICCIO, LYNN D. WILSON, BENJAMIN H. KANN, VIKRAM JAIRAM, JASON BECKTA, FRANCINE M. FOSS and DEBRA N. YEBOA

  Anticancer Research January 2019, 39 (1) 253-259; DOI: https://doi.org/10.21873/anticanres.13105
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  Comparison of a New-generation Fecal Immunochemical Test (FIT) With Guaiac Fecal Occult Blood Test (gFOBT) in Detecting Colorectal Neoplasia Among Colonoscopy-referral Patients

  DENISE PEIXOTO GUIMARÃES, JOSE HUMBERTO FREGNANI, RUI MANUEL REIS, LEONARDO NOGUEIRA TAVEIRA, CRISTOVAM SCAPULATEMPO-NETO, MARCUS MATSUSHITA, SANDRA REGINA MORINI SILVA, CEYTON ZANARDO OLIVEIRA, ADHEMAR LONGATTO-FILHO, CARITA EKLUND, LEA PALOHEIMO, EDMUNDO MAUAD, OSMO SUOVANIEMI and KARI SYRJÄNEN

  Anticancer Research January 2019, 39 (1) 261-269; DOI: https://doi.org/10.21873/anticanres.13106
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  Cancer Patients' Symptom Burden and Health-related Quality of Life (HRQoL) at Tertiary Cancer Center from 2006 to 2013: A Cross-sectional Study

  KRISTIINA KOKKONEN, TIINA TASMUTH, JUHO T. LEHTO, HANNU KAUTIAINEN, ANNELI ELME, ANNA-STINA JÄÄSKELÄINEN and TIINA SAARTO

  Anticancer Research January 2019, 39 (1) 271-277; DOI: https://doi.org/10.21873/anticanres.13107
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  Effective Antiemetic Therapy Is Important With Adjuvant Anthracycline-based Chemotherapy in Breast Cancer

  LAURA TAKALA, MAARIT BÄRLUND and PIRKKO-LIISA KELLOKUMPU-LEHTINEN

  Anticancer Research January 2019, 39 (1) 279-283; DOI: https://doi.org/10.21873/anticanres.13108
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  Validation of a Clinical Cancer Register at the Head and Neck Oncology Center in Örebro

  ERIK LUNDIN, MICHAEL BERGQVIST, JOHAN AHLGREN, JOHAN REIZENSTEIN and BO LENNERNÄS

  Anticancer Research January 2019, 39 (1) 285-289; DOI: https://doi.org/10.21873/anticanres.13109
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  Osteoid Osteoma of the Mandible – Clinical and Histological Findings

  LEVI MATTHIES, TIM ROLVIEN, THOMAS J. PAKUSA, CHRISTIAN KNIPFER, MARTIN GOSAU, MICHAEL AMLING, REINHARD E. FRIEDRICH and JOZEF ZUSTIN

  Anticancer Research January 2019, 39 (1) 291-296; DOI: https://doi.org/10.21873/anticanres.13110
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  Gene-expression Profiling – A Decision Impact Analysis: Decision Dependency on Oncotype DX® as a Function of Oncological Work Experience in 117 Cases

  CHRISTIAN EICHLER, JULIA FROMME, FABINSHY THANGARAJAH, JULIAN PUPPE, STEFAN PAEPKE, MATHIAS WARM and WOLFRAM MALTER

  Anticancer Research January 2019, 39 (1) 297-303; DOI: https://doi.org/10.21873/anticanres.13111
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  Positive Association of Male Overactive Bladder Symptoms and Androgen Deprivation: A Nationwide Population-based Cohort Study

  JIAN-RI LI, SHIAN-SHIANG WANG, CHING-HENG LIN, WILLIAM C. DE GROAT and CHEN-LI CHENG

  Anticancer Research January 2019, 39 (1) 305-311; DOI: https://doi.org/10.21873/anticanres.13112
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  Assessment of the Applicability of Integrative Tumor Response Assays in Advanced Epithelial Ovarian Cancer

  JU-HYUN KIM, YONG SIK YOON, JIN CHEON KIM and YONG-MAN KIM

  Anticancer Research January 2019, 39 (1) 313-318; DOI: https://doi.org/10.21873/anticanres.13113
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  Expression of Notch 3 and Jagged 1 Is Associated With Merkel Cell Polyomavirus Status and Prognosis in Merkel Cell Carcinoma

  LUSI OKA WARDHANI, MICHIKO MATSUSHITA, SATOSHI KUWAMOTO, DAISUKE NONAKA, KEIKO NAGATA, MASAKO KATO, YUKISATO KITAMURA and KAZUHIKO HAYASHI

  Anticancer Research January 2019, 39 (1) 319-329; DOI: https://doi.org/10.21873/anticanres.13114
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  Tumor Resection May Improve Survival in Patients With Soft Tissue Sarcoma Aged 75 Years and Older

  TOMOKI NAKAMURA, TORU OI, KUNIHIRO ASANUMA, TOMOHITO HAGI and AKIHIRO SUDO

  Anticancer Research January 2019, 39 (1) 331-334; DOI: https://doi.org/10.21873/anticanres.13115
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  Initiation of Systemic Therapy During the Last 30 Days of Life in Patients With Metastatic Castration-resistant Prostate Cancer

  CARSTEN NIEDER, ELLINOR HAUKLAND, BÅRD MANNSÅKER, ADAM PAWINSKI, ROSALBA YOBUTA and JAN NORUM

  Anticancer Research January 2019, 39 (1) 335-340; DOI: https://doi.org/10.21873/anticanres.13116
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  The Relationship Between ¹⁸F-FDG Uptake on PET/CT and Markers of Systemic Inflammatory Response in Patients Undergoing Surgery for Intrahepatic Cholangiocarcinoma

  SATORU SEO, TOMOAKI YOH, KOSHIRO MORINO, HIROAKI FUJI, KOJIRO TAURA, KEN FUKUMITSU, TAKAMICHI ISHII, YUJI NAKAMOTO, TOSHIMI KAIDO and SHINJI UEMOTO

  Anticancer Research January 2019, 39 (1) 341-346; DOI: https://doi.org/10.21873/anticanres.13117
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  Gemcitabine Re-challenge in Metastatic Soft Tissue Sarcomas: A Therapeutic Option for Selected Patients

  ANA SEBIO, ANASTASIA CONSTANTINIDOU, CHARLOTTE BENSON, GEORGIOS ANTONIOU, CHRISTINA MESSIOU, AISHA MIAH, SHANE ZAIDI, ANN PETRUCKEVITCH, OMAR AL-MUDERIS, KHIN THWAY, WINETTE T. VAN DER GRAAF and ROBIN L. JONES

  Anticancer Research January 2019, 39 (1) 347-351; DOI: https://doi.org/10.21873/anticanres.13118
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  Costs in Different States of Breast Cancer

  EIJA ROINE, NIILO FÄRKKILÄ, HARRI SINTONEN, KIMMO TAARI, RISTO P. ROINE and TIINA SAARTO

  Anticancer Research January 2019, 39 (1) 353-359; DOI: https://doi.org/10.21873/anticanres.13119
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  Risk Factors for Sacral Insufficiency Fractures in Cervical Cancer After Whole Pelvic Radiation Therapy

  MASAKUNI SAKAGUCHI, TOSHIYA MAEBAYASHI, TAKUYA AIZAWA and NAOYA ISHIBASHI

  Anticancer Research January 2019, 39 (1) 361-367; DOI: https://doi.org/10.21873/anticanres.13120
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  Clinicopathological and Molecular Characteristics of Mammary Adenoid Cystic Carcinoma With Adipocytic Differentiation With Emphasis on the Identification of a Novel BRAF Mutation

  GO EUN BAE, NARA YOON, EUN YOON CHO, HYUN-SOO KIM and SOO YOUN CHO

  Anticancer Research January 2019, 39 (1) 369-374; DOI: https://doi.org/10.21873/anticanres.13121
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  High Serum CA19-9 Concentration Indicates High Chemosensitivity and Better Survival in Advanced Urothelial Carcinoma

  HIROSHI YAEGASHI, KOUJI IZUMI, SUGURU KADOMOTO, RENATO NAITO, TOMOYUKI MAKINO, HIROAKI IWAMOTO, TAKAHIRO NOHARA, KAZUYOSHI SHIGEHARA, YOSHIFUMI KADONO and ATSUSHI MIZOKAMI

  Anticancer Research January 2019, 39 (1) 375-380; DOI: https://doi.org/10.21873/anticanres.13122
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  Detection of HPV mRNA in Self-collected Vaginal Samples Among Women at 69-70 Years of Age

  AVALON ERNSTSON, KATRIN CHRISTINE ASCIUTTO, JOHAN STURESSON, JONAS NORÉN, OLA FORSLUND and CHRISTER BORGFELDT

  Anticancer Research January 2019, 39 (1) 381-386; DOI: https://doi.org/10.21873/anticanres.13123
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  Mesenchymal Stem Cell Marker Expression in Gastric Cancer Stroma

  SATOE NUMAKURA, HIROSHI UOZAKI, YOSHINAO KIKUCHI, SHIORI WATABE, ARISA TOGASHI and MASATO WATANABE

  Anticancer Research January 2019, 39 (1) 387-393; DOI: https://doi.org/10.21873/anticanres.13124
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  Prognostic Impact of β2 Adrenergic Receptor Expression in Surgically Resected Pulmonary Pleomorphic Carcinoma

  KYOICHI KAIRA, MITSUHIRO KAMIYOSHIHARA, OSAMU KAWASHIMA, HIDEKI ENDOH, KAZUYOSHI IMAIZUMI, MASAYUKI SUGANO, SHIGEFUMI TANAKA, ATSUSHI FUJITA, YOSHIHITO KOGURE, AKIRA SHIMIZU, TETSUNARI OYAMA, TAKAYUKI ASAO, KIMIHIRO SHIMIZU and AKIRA MOGI

  Anticancer Research January 2019, 39 (1) 395-403; DOI: https://doi.org/10.21873/anticanres.13125
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  Prognostic Significance of Pretreatment Lymphocyte–to–Monocyte Ratio in Patients with Tongue Cancer

  KOHEI FURUKAWA, GORO KAWASAKI, TOMOFUMI NARUSE and MASAHIRO UMEDA

  Anticancer Research January 2019, 39 (1) 405-412; DOI: https://doi.org/10.21873/anticanres.13126
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  Use of ALK Immunohistochemistry for Optimal Therapeutic Strategy of Pulmonary Large-cell Neuroendocrine Carcinoma and Identification of a Novel KIF5B–ALK Fusion Oncokinase

  NAOKI SHIMIZU, YUSAKU AKASHI, TOMOMI FUJII, HIROYUKI SHIONO, KATSUNARI YANE, TADASHI KITAHARA, YOSHIO OHTA, KENNICHI KAKUDO and TOMOKO WAKASA

  Anticancer Research January 2019, 39 (1) 413-420; DOI: https://doi.org/10.21873/anticanres.13127
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  L1CAM as a Negative Prognostic Factor in Endometrioid Endometrial Adenocarcinoma FIGO Stage IA-IB

  JAROSLAV KLAT, ALES MLADENKA, JANA DVORACKOVA, SYLVA BAJSOVA and ONDREJ SIMETKA

  Anticancer Research January 2019, 39 (1) 421-424; DOI: https://doi.org/10.21873/anticanres.13128
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  Lower Esophageal Sphincter-preserving Anastomosis Is an Acceptable Reconstruction Method Following Laparoscopy-assisted Proximal Gastrectomy

  DONG JIN KIM and WOOK KIM

  Anticancer Research January 2019, 39 (1) 425-430; DOI: https://doi.org/10.21873/anticanres.13129
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  B-ALL Relapses After Autologous Stem Cell Transplantation Associated With a Shift from e1a2 to e14a2 BCR-ABL Transcripts: A Case Report

  STEFANIA STELLA, MICHELE MASSIMINO, ELENA TIRRÒ, SILVIA RITA VITALE, LUCA SCALISE, SALVATORE LEOTTA, MARIA STELLA PENNISI, ADRIANA PUMA, CHIARA ROMANO, FABIO STAGNO, GIUSEPPE SAPIENZA, GIUSEPPE MILONE and LIVIA MANZELLA

  Anticancer Research January 2019, 39 (1) 431-435; DOI: https://doi.org/10.21873/anticanres.13130
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  Polypoid Undifferentiated Carcinoma With Osteoclast-like Giant Cells Arising in the Distal Common Bile Duct: A Rare Case Report

  XIAOYAN LIAO, JANE HOULDSWORTH, JEAN LUO, NOAM HARPAZ and HONGFA ZHU

  Anticancer Research January 2019, 39 (1) 437-441; DOI: https://doi.org/10.21873/anticanres.13131
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  PD-1 Expression on Circulating CD8⁺ T-Cells as a Prognostic Marker for Patients With Gastric Cancer

  HIROAKI SAITO, SHOTA SHIMIZU, YUSUKE KONO, YUKI MURAKAMI, YUJI SHISHIDO, KOZO MIYATANI, TOMOYUKI MATSUNAGA, YOJI FUKUMOTO, KEIGO ASHIDA and YOSHIYUKI FUJIWARA

  Anticancer Research January 2019, 39 (1) 443-448; DOI: https://doi.org/10.21873/anticanres.13132
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  Prognostic Significance of Sarcopenia and Systemic Inflammatory Response in Patients With Esophageal Cancer

  TOMOYUKI MATSUNAGA, HIROSHI MIYATA, KEIJIRO SUGIMURA, MASAAKI MOTOORI, KEI ASUKAI, YOSHITOMO YANAGIMOTO, YUSUKE TAKAHASHI, AKIRA TOMOKUNI, KAZUYOSHI YAMAMOTO, HIROFUMI AKITA, JUNICHI NISHIMURA, HIROSHI WADA, HIDENORI TAKAHASHI, MASAYOSHI YASUI, TAKESHI OMORI, MASAYUKI OUE and MASAHIKO YANO

  Anticancer Research January 2019, 39 (1) 449-458; DOI: https://doi.org/10.21873/anticanres.13133
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  No Ink on Ductal Carcinoma In Situ: A Single Centre Experience

  PIERO FREGATTI, MARCO GIPPONI, FRANCESCA DEPAOLI, FEDERICA MURELLI, MARINA GUENZI, ELISABETTA BONZANO, MARCELLO CEPPI and DANIELE FRIEDMAN

  Anticancer Research January 2019, 39 (1) 459-466; DOI: https://doi.org/10.21873/anticanres.13134
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  Scheduled Intravenous Acetaminophen for Postoperative Management of Patients Who Had Thoracoscopic Esophagectomy for Esophageal Cancer

  HIROYUKI KITAGAWA, TSUTOMU NAMIKAWA, JUN IWABU, SUNAO UEMURA, MASAYA MUNEKAGE, SACHI TSUDA, KEIICHIRO YOKOTA, MICHIYA KOBAYASHI and KAZUHIRO HANAZAKI

  Anticancer Research January 2019, 39 (1) 467-470; DOI: https://doi.org/10.21873/anticanres.13135
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  Influence of Neoadjuvant Chemotherapy on Short-term Outcomes After Minimally Invasive Esophagectomy for Esophageal Cancer

  DAICHI NOMOTO, NAOYA YOSHIDA, TAKAHIKO AKIYAMA, YUKI KIYOZUMI, KOJIRO ETO, YUKIHARU HIYOSHI, YOHEI NAGAI, MASAAKI IWATSUKI, SHIRO IWAGAMI, YOSHIFUMI BABA, YUJI MIYAMOTO and HIDEO BABA

  Anticancer Research January 2019, 39 (1) 471-475; DOI: https://doi.org/10.21873/anticanres.13136
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  Health-related Quality of Life and Toxicity After Single-fraction High-dose-rate Brachytherapy With External Beam Radiotherapy for Localized and Locally Advanced Prostate Cancer

  TOMOYUKI MAKINO, KAZUFUMI NAKASHIMA, MASASHI IIJIMA, SHOUHEI KAWAGUCHI, TAKAHIRO NOHARA, KAZUYOSHI SHIGEHARA, KOUJI IZUMI, YOSHIFUMI KADONO, TOMOYASU KUMANO and ATSUSHI MIZOKAMI

  Anticancer Research January 2019, 39 (1) 477-486; DOI: https://doi.org/10.21873/anticanres.13137
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  An Unusual Case of Cecal Mesenteric Dedifferentiated Liposarcoma Involving the Ileocolic Artery Resected by Right Hemicolectomy

  DONGWEI ZHANG, WILLIAM D. WILLIAMS and JINPING LAI

  Anticancer Research January 2019, 39 (1) 487-490; DOI: https://doi.org/10.21873/anticanres.13138
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  Predictors of Acute Radiation Esophagitis in Non-small Cell Lung Cancer Patients Treated With Accelerated Hyperfractionated Chemoradiotherapy

  KENTARO WADA, NORIKO KISHI, NAOYUKI KANAYAMA, TAKERO HIRATA, YOSHIHIRO UEDA, YOSHIFUMI KAWAGUCHI, MASAHIRO MORIMOTO, KOJI KONISHI, FUMIO IMAMURA, KAZUHIKO OGAWA and TERUKI TESHIMA

  Anticancer Research January 2019, 39 (1) 491-497; DOI: https://doi.org/10.21873/anticanres.13139
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  Predictive Factors of Pancreatic Fistula After Pancreaticoduodenectomy and External Validation of Predictive Scores

  MARCELLO DI MARTINO, ISMAEL MORA-GUZMAN, YAGO GARCÍA BLANCO-TRABA, MIGUEL CANTALEJO DÍAZ, MUHAMMAD ARSLAN KHURRAM and ELENA MARTÍN-PÉREZ

  Anticancer Research January 2019, 39 (1) 499-504; DOI: https://doi.org/10.21873/anticanres.13140
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  Essentiality of Imaging Diagnostic Criteria Specific to Rectal Neuroendocrine Tumors for Detecting Metastatic Lymph Nodes

  MICHIHIRO KUDOU, TOMOHIRO ARITA, MASAYOSHI NAKANISHI, YOSHIAKI KURIU, YASUTOSHI MURAYAMA, KATSUTOSHI SHODA, TOSHIYUKI KOSUGA, HIROTAKA KONISHI, RYO MORIMURA, ATSUSHI SHIOZAKI, HISASHI IKOMA, TAKESHI KUBOTA, HITOSHI FUJIWARA, KAZUMA OKAMOTO and EIGO OTSUJI

  Anticancer Research January 2019, 39 (1) 505-510; DOI: https://doi.org/10.21873/anticanres.13141
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  Outcomes of Localized Esophageal Squamous Cell Carcinoma Patients Treated With Definitive Concurrent Chemoradiotherapy Using Either Standard or High Radiotherapy Dose: A Retrospective Study Controlling for Organ at Risk Dose

  CHIA-CHIN LI, HSIN-YUAN FANG, CHEN-YUAN LIN, WEI-CHIH SHEN and CHUN-RU CHIEN

  Anticancer Research January 2019, 39 (1) 511-517; DOI: https://doi.org/10.21873/anticanres.13142
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  Metabolomics-based Discovery of Serum Biomarkers to Predict the Side-effects of Neoadjuvant Chemoradiotherapy for Esophageal Squamous Cell Carcinoma

  SHIN NISHIUMI, SEIJI FUJIGAKI, TAKASHI KOBAYASHI, TAKASHI KOJIMA, YOSHINORI ITO, HIROYUKI DAIKO, KEN KATO, HIROKAZU SHOJI, YUZO KODAMA, KAZUFUMI HONDA and MASARU YOSHIDA

  Anticancer Research January 2019, 39 (1) 519-526; DOI: https://doi.org/10.21873/anticanres.13143