Table of Contents

Clinical Studies

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  Overexpression of FGFR3 in HPV-positive Tonsillar and Base of Tongue Cancer Is Correlated to Outcome

  CINZIA BERSANI, LINNEA HAEGGBLOM, RAMONA G. URSU, SIMONA E. GIUSCA, LINDA MARKLUND, TORBJÖRN RAMQVIST, ANDERS NÄSMAN and TINA DALIANIS

  Anticancer Research August 2018, 38 (8) 4683-4690; DOI: https://doi.org/10.21873/anticanres.12774
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  Prophylactic Effect of Polaprezinc, a Zinc-L-carnosine, Against Chemotherapy-induced Oral Mucositis in Pediatric Patients Undergoing Autologous Stem Cell Transplantation

  MIYUI FUNATO, MICHIO OZEKI, AKIO SUZUKI, MASASHI ISHIHARA, RYO KOBAYASHI, AKIFUMI NOZAWA, SHIHO YASUE, SAORI ENDO-OHNISHI, TOSHIYUKI FUKAO and YOSHINORI ITOH

  Anticancer Research August 2018, 38 (8) 4691-4697; DOI: https://doi.org/10.21873/anticanres.12775
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  Phase I Study Evaluating the Combination of Afatinib with Carboplatin and Pemetrexed After First-line EGFR-TKIs

  SATOSHI WATANABE, OU YAMAGUCHI, AI MASUMOTO, YURI MAENO, YOSUKE KAWASHIMA, OSAMU ISHIMOTO, SHUNICHI SUGAWARA, HIROHISA YOSHIZAWA, TOSHIAKI KIKUCHI, TOSHIHIRO NUKIWA and KUNIHIKO KOBAYASHI

  Anticancer Research August 2018, 38 (8) 4699-4704; DOI: https://doi.org/10.21873/anticanres.12776
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  Prognostic Significance of Neutrophil–to–lymphocyte Ratio in the Framework of the 8th TNM Edition for Breast Cancer

  PATRIZIA FERRONI, MARIO ROSELLI, ORESTE C. BUONOMO, ANTONELLA SPILA, ILARIA PORTARENA, ANASTASIA LAUDISI, MARIA G. VALENTE, SILVANA P. PIRILLO, LUCIO FORTUNATO, LEOPOLDO COSTARELLI, FRANCESCO CAVALIERE and FIORELLA GUADAGNI

  Anticancer Research August 2018, 38 (8) 4705-4712; DOI: https://doi.org/10.21873/anticanres.12777
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  Tumor Budding Versus Mismatch Repair Status in Colorectal Cancer – An Exploratory Analysis

  MIA KARLBERG, KRISTINA STENSTEDT, MARJA HALLSTRÖM, PETER RAGNHAMMAR, CLAES LENANDER and DAVID EDLER

  Anticancer Research August 2018, 38 (8) 4713-4721; DOI: https://doi.org/10.21873/anticanres.12778
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  Clinical Characteristics of Liver Metastasis in Nivolumab-treated Patients with Non-small Cell Lung Cancer

  TAKAYUKI SHIROYAMA, HIDEKAZU SUZUKI, MOTOHIRO TAMIYA, AKIHIRO TAMIYA, AYAKO TANAKA, NORIO OKAMOTO, KENJI NAKAHAMA, YOSHIHIKO TANIGUCHI, SHUN-ICHI ISA, TAKAKO INOUE, FUMIO IMAMURA, SHINJI ATAGI and TOMONORI HIRASHIMA

  Anticancer Research August 2018, 38 (8) 4723-4729; DOI: https://doi.org/10.21873/anticanres.12779
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  The Frequency and Prognostic Value of Neutrophilia in Chronic Lymphocytic Leukemia

  ILANA LEVY, ZAHAVA VADASZ, AARON POLLIACK and TAMAR TADMOR

  Anticancer Research August 2018, 38 (8) 4731-4734; DOI: https://doi.org/10.21873/anticanres.12780
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  Preoperative Prognostic Nutritional Index Predicts Long-term Outcome in Gastric Cancer: A Propensity Score-matched Analysis

  NORIYUKI HIRAHARA, YOSHITSUGU TAJIMA, YUSUKE FUJII, TETSU YAMAMOTO, RYOJI HYAKUDOMI, TAKAHITO TANIURA, SHUNSUKE KAJI and YASUNARI KAWABATA

  Anticancer Research August 2018, 38 (8) 4735-4746; DOI: https://doi.org/10.21873/anticanres.12781
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  The Impact of EndoPredict Clinical Score on Chemotherapy Recommendations in Women with Invasive ER⁺/HER2⁻ Breast Cancer Stratified as Having Moderate or Poor Prognosis by Nottingham Prognostic Index

  KINAN MOKBEL, UMAR WAZIR, ALI WAZIR, ABDUL KASEM and KEFAH MOKBEL

  Anticancer Research August 2018, 38 (8) 4747-4752; DOI: https://doi.org/10.21873/anticanres.12782
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  Chitinase-3-like Protein 1 (YKL-40) Expression in Squamous Cell Skin Cancer

  JOANNA SALOMON, ALEKSANDRA PIOTROWSKA, ŁUKASZ MATUSIAK, PIOTR DZIĘGIEL and JACEK C. SZEPIETOWSKI

  Anticancer Research August 2018, 38 (8) 4753-4758; DOI: https://doi.org/10.21873/anticanres.12783
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  Diagnostic Utility of Prostein, Uroplakin II and SATB2 for Diagnosing Carcinoma of Unknown Primary Origin: A Systematic Immunohistochemical Profiling

  KUNIO MOCHIZUKI, MASATAKA KAWAI, TORU ODATE, IPPEI TAHARA, TOMOHIRO INOUE, KAZUNARI KASAI, TADAO NAKAZAWA, RYOHEI KATOH and TETSUO KONDO

  Anticancer Research August 2018, 38 (8) 4759-4766; DOI: https://doi.org/10.21873/anticanres.12784
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  Relationship Among Tumor Attenuation Value of Pre-contrast Computed Tomography (CT), Washout Rate and Constituent Cells in Adrenal Adenoma: Proposition of a New Approach for Diagnosing Adrenal Adenoma on Dynamic CT

  AKIHIRO NISHIE, MASAAKI SUGIMOTO, YOSHIKI ASAYAMA, KOUSEI ISHIGAMI, YASUHIRO USHIJIMA, YUKIHISA TAKAYAMA, DAISUKE OKAMOTO, NOBUHIRO FUJITA, AKIRA YOKOMIZO, KATSUNORI TATSUGAMI and HIROSHI HONDA

  Anticancer Research August 2018, 38 (8) 4767-4773; DOI: https://doi.org/10.21873/anticanres.12785
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  Pilot Study of Probe-based Confocal Laser Endomicroscopy with Fluorescein-dripping Method for Liver Tumors

  MASAKI MORIMOTO, SOICHIRO HONJO, TERUHISA SAKAMOTO, EI UCHINAKA, MASATAKA AMISAKI, YOSUKE ARAI, MANABU YAMAMOTO, YOJI FUKUMOTO, TOMOHIRO OSAKI, NARUO TOKUYASU, KEIGO ASHIDA, HIROAKI SAITO and YOSHIYUKI FUJIWARA

  Anticancer Research August 2018, 38 (8) 4775-4781; DOI: https://doi.org/10.21873/anticanres.12786
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  Chemoradiotherapy-induced Changes in Mucinous Components in Rectal Cancer Tissue: Evaluation on High Iron Diamine-alcian Blue and Mucin 1 Staining

  HIROSHI MIYAKITA, SOTARO SADAHIRO, YUTARO KAMEI, TAKASHI OGIMI, GOTA SAITO, KAZUTAKE OKADA, AKIRA TANAKA, TOSHIYUKI SUZUKI, HIROSHI KAJIWARA and TAKESHI AKIBA

  Anticancer Research August 2018, 38 (8) 4783-4787; DOI: https://doi.org/10.21873/anticanres.12787
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  Treatment of Adrenal Metastases with Conventional or Hypofractionated Image-guided Radiation Therapy – Patterns and Outcomes

  DANIEL BUERGY, LEONIE RABE, KERSTIN SIEBENLIST, FLORIAN STIELER, JENS FLECKENSTEIN, FRANK A. GIORDANO, FREDERIK WENZ and JUDIT BODA-HEGGEMANN

  Anticancer Research August 2018, 38 (8) 4789-4796; DOI: https://doi.org/10.21873/anticanres.12788
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  Clinical Impact of Histological Heterogeneity in the Metastatic Lymph Nodes of Patients with Colorectal Cancer

  KAZUYOSHI HIRAYAMA, MAKOTO SUDOH, HIROKI SHIMIZU, SHINJI FURUYA, YOSHIHIRO AKAZAWA, HIROSHI IINO, KENSUKE SHIRAISHI, HIDENORI AKAIKE, NAOHIRO HOSOMURA, YOSHIHIKO KAWAGUCHI, HIDETAKE AMEMIYA, HIROMITSU KAWAIDA, SHINGO INOUE, HIROSHI KONO, HIDEKI FUJII and DAISUKE ICHIKAWA

  Anticancer Research August 2018, 38 (8) 4797-4803; DOI: https://doi.org/10.21873/anticanres.12789
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  A Phase I Study of S-1-based Concurrent Chemoradiotherapy Followed by Gemcitabine and S-1 in Metastatic Pancreatic Adenocarcinoma

  SHIH-HUNG YANG, YU-YUN SHAO, CHIA-CHI LIN, SUNG-HSIN KUO, ANN-LII CHENG and KUN-HUEI YEH

  Anticancer Research August 2018, 38 (8) 4805-4812; DOI: https://doi.org/10.21873/anticanres.12790
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  Preoperative Evaluation of Myometrial Invasion in Endometrial Carcinoma: Prospective Intra-individual Comparison of Magnetic Resonance Volumetry, Diffusion-weighted and Dynamic Contrast-enhanced Magnetic Resonance Imaging

  STEFAN FELIX THIEME, FEDERICO COLLETTINI, JALID SEHOULI, LUCIO BIOCCA, ALESSANDRA LELLA, MORITZ WAGNER, JUMANA ALMUHEIMID, HELMUT PLETT and MUSTAFA ZELAL MUALLEM

  Anticancer Research August 2018, 38 (8) 4813-4817; DOI: https://doi.org/10.21873/anticanres.12791
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  Nuclear Expression of CD133 Is Associated with Good Prognosis in Patients with Colorectal Adenocarcinoma

  YONG-MOON LEE, MIN-KYUNG YEO, IN-OCK SEONG and KYUNG-HEE KIM

  Anticancer Research August 2018, 38 (8) 4819-4826; DOI: https://doi.org/10.21873/anticanres.12792
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  Partial Bladder Boost Using Lipiodol Marking During Image-guided Radiotherapy for Bladder Cancer

  RYUJI NAKAMURA, HISAO KAKUHARA, KOYO KIKUCHI, TAKAFUMI SEGAWA, HIROBUMI OIKAWA, KAZUHIRO IWASAKI, WATARU OBARA and HISANORI ARIGA

  Anticancer Research August 2018, 38 (8) 4827-4831; DOI: https://doi.org/10.21873/anticanres.12793
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  Predicting the Ambulatory Status of Patients Irradiated for Metastatic Spinal Cord Compression (MSCC) from Head-and-neck Cancer

  DIRK RADES, CHRISTIAN STAACKMANN and STEFAN JANSSEN

  Anticancer Research August 2018, 38 (8) 4833-4837; DOI: https://doi.org/10.21873/anticanres.12794
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  Platinum-based Agent and Fluorouracil in Metastatic Breast Cancer: A Retrospective Monocentric Study with a Review of the Literature

  LORENZO ROSSI, CHIARA BIAGIONI, AMELIA MCCARTNEY, ERICA MORETTI, MARTA PESTRIN, GIUSEPPINA SANNA, EMANUELA RISI, LUCA MALORNI, ANGELO DI LEO and LAURA BIGANZOLI

  Anticancer Research August 2018, 38 (8) 4839-4845; DOI: https://doi.org/10.21873/anticanres.12795
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  Sigmoid Colon Adenocarcinoma with Isolated Loss of PMS2 Presenting in a Patient with Synchronous Prostate Cancer with Intact MMR: Diagnosis and Analysis of the Family Pedigree

  WEIDONG LIU, DONGWEI ZHANG, SANDA A. TAN, XIULI LIU and JINPING LAI

  Anticancer Research August 2018, 38 (8) 4847-4852; DOI: https://doi.org/10.21873/anticanres.12796
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  Cost-Effectiveness of Carbon Ion Radiation Therapy for Skull Base Chordoma Utilizing Long-Term (10-Year) Outcome Data

  TANJA SPRAVE, VIVEK VERMA, FLORIAN STERZING, THOMAS BRUCKNER, KATHARINA HEES, BEATE LAND, OLIVER JÄKEL, KLAUS HERFARTH, JÜRGEN DEBUS and MATTHIAS UHL

  Anticancer Research August 2018, 38 (8) 4853-4858; DOI: https://doi.org/10.21873/anticanres.12797
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  Development of a Questionnaire for Monitoring Risk Factors for Chemotherapy-induced Nausea and Vomiting – A NOGGO Pilot Study

  HANNAH RITTMEISTER, GÜLTEN OSKAY-ÖZCELIK, ROLF RICHTER, JALID SEHOULI and JACEK P. GRABOWSKI

  Anticancer Research August 2018, 38 (8) 4859-4864; DOI: https://doi.org/10.21873/anticanres.12798
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  Preoperative CA-125 Value as a Predictive Factor for Postoperative Outcome in First Relapse of Platinum-sensitive Serous Ovarian Cancer

  ASYA PARASHKEVOVA, JALID SEHOULI, ROLF RICHTER, DESISLAVA DIMITROVA, ELENA IOANA BRAICU and MUSTAFA ZELAL MUALLEM

  Anticancer Research August 2018, 38 (8) 4865-4870; DOI: https://doi.org/10.21873/anticanres.12799
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  Predictors for High Microsatellite Instability in Patients with Colorectal Cancer Fulfilling the Revised Bethesda Guidelines

  KEIICHI ARAKAWA, KEISUKE HATA, KAZUSHIGE KAWAI, TOSHIAKI TANAKA, TAKESHI NISHIKAWA, KAZUHITO SASAKI, YASUTAKA SHUNO, MANABU KANEKO, MASAYA HIYOSHI, SHIGENOBU EMOTO, KOJI MURONO and HIROAKI NOZAWA

  Anticancer Research August 2018, 38 (8) 4871-4876; DOI: https://doi.org/10.21873/anticanres.12800
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  The Lymph Node Ratio Is an Independent Prognostic Factor in Pancreatic Cancer Patients Who Receive Curative Resection Followed by Adjuvant Chemotherapy

  TORU AOYAMA, NAOTO YAMAMOTO, MARIKO KAMIYA, MASAAKI MURAKAWA, HIROSHI TAMAGAWA, SHO SAWAZAKI, MASAKATSU NUMATA, MANABU SHIOZAWA, SATOSHI KOBAYASHI, MAKOTO UENO, MANABU MORIMOTO, NORIO YUKAWA, TAKASHI OSHIMA, TAKAKI YOSHIKAWA, YASUSHI RINO, MUNETAKA MASUDA and SOICHIRO MORINAGA

  Anticancer Research August 2018, 38 (8) 4877-4882; DOI: https://doi.org/10.21873/anticanres.12801
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  Controlling Nutritional Status (CONUT) Score Is a Prognostic Marker in Metastatic Colorectal Cancer Patients Receiving First-line Chemotherapy

  NOBUYA DAITOKU, YUJI MIYAMOTO, RYUMA TOKUNAGA, YUKI SAKAMOTO, YUKIHARU HIYOSHI, MASAAKI IWATSUKI, YOSHIFUMI BABA, SHIRO IWAGAMI, NAOYA YOSHIDA and HIDEO BABA

  Anticancer Research August 2018, 38 (8) 4883-4888; DOI: https://doi.org/10.21873/anticanres.12802
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  CT Texture Analysis of Ductal Adenocarcinoma Downstaged After Chemotherapy

  VALENTINA CIARAVINO, NICOLÒ CARDOBI, RICCARDO DE ROBERTIS, PAOLA CAPELLI, DAVIDE MELISI, FRANCESCA SIMIONATO, GIOVANNI MARCHEGIANI, ROBERTO SALVIA and MIRKO D'ONOFRIO

  Anticancer Research August 2018, 38 (8) 4889-4895; DOI: https://doi.org/10.21873/anticanres.12803
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  Brainstem Glioblastoma Multiforme in a Patient with NF1

  JOHN T. FORTUNATO, BRIAN REYS, PAWAN SINGH and EDWARD PAN

  Anticancer Research August 2018, 38 (8) 4897-4900; DOI: https://doi.org/10.21873/anticanres.12804
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  The Effect of Roux-en-Y Reconstruction on Type 2 Diabetes in the Early Postoperative Period

  HIDEYA KASHIHARA, MITSUO SHIMADA, KOZO YOSHIKAWA, JUN HIGASHIJIMA, TOMOHIKO MIYATANI, TAKUYA TOKUNAGA, MASAAKI NISHI and CHIE TAKASU

  Anticancer Research August 2018, 38 (8) 4901-4905; DOI: https://doi.org/10.21873/anticanres.12805
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  OPG, OPN, EGF and VEGF Levels at Individual Breslow Score Stages in Malignant Melanoma

  INKA TRESKOVA, ONDREJ TOPOLCAN, JINDRA WINDRICHOVA, VACLAV SIMANEK, DAVID SLOUKA, VLADISLAV TRESKA and RADEK KUCERA

  Anticancer Research August 2018, 38 (8) 4907-4911; DOI: https://doi.org/10.21873/anticanres.12806
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  Long-term Response to First-line Pazopanib Therapy in mRCC Patients: A Multicenter Italian Experience

  ANDREA SBRANA, ELISA BIASCO, FEDERICO PAOLIERI, ERICA PALESANDRO, CLAUDIA CASERTA, ROBERTO IACOVELLI, BEATRICE DETTI, DANIELE SANTINI, ALESSANDRA MOSCA, FRANCO MORELLI, GIUSEPPE FORNARINI, UGO DE GIORGI, CRISTINA MASINI and LUCA GALLI

  Anticancer Research August 2018, 38 (8) 4913-4918; DOI: https://doi.org/10.21873/anticanres.12807
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  Treatment of Naïve HCC Combined with Segmental or Subsegmental Portal Vein Tumor Thrombosis: Liver Resection Versus TACE Followed by Radiotherapy

  JEONG IL YU, GYU-SEONG CHOI, DO HOON LIM, EONJU LEE, JAE-WON JOH, CHOON HYUCK DAVID KWON, JONG MAN KIM, SEONWOO KIM, SOOK-YOUNG WOO, SEUNG WOON PAIK and HEE CHUL PARK

  Anticancer Research August 2018, 38 (8) 4919-4925; DOI: https://doi.org/10.21873/anticanres.12808
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  Relationship Between FDG Uptake and Neutrophil/Lymphocyte Ratio in Patients with Invasive Ductal Breast Cancer

  TAKAAKI FUJII, KEIKO YANAI, SHOKO TOKUDA, YUKO NAKAZAWA, SASAGU KUROZUMI, SAYAKA OBAYASHI, REINA YAJIMA, TOMOKO HIRAKATA and KEN SHIRABE

  Anticancer Research August 2018, 38 (8) 4927-4931; DOI: https://doi.org/10.21873/anticanres.12809
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  Skeletal Muscle Volume and Intramuscular Adipose Tissue Are Prognostic Predictors of Postoperative Complications After Hepatic Resection

  NORIFUMI HARIMOTO, HIROKI HOSHINO, RYO MURANUSHI, KEI HAGIWARA, TAKAHIRO YAMANAKA, NORIHIRO ISHII, MARIKO TSUKAGOSHI, TAKAMICHI IGARASHI, AKIRA WATANABE, NORIO KUBO, KENICHIROU ARAKI and KEN SHIRABE

  Anticancer Research August 2018, 38 (8) 4933-4939; DOI: https://doi.org/10.21873/anticanres.12810
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  Comparison of Feeding Jejunostomy via Gastric Tube Versus Jejunum After Esophageal Cancer Surgery

  TOMOKI KONISHI, ATSUSHI SHIOZAKI, HITOSHI FUJIWARA, HIROTAKA KONISHI, KENICHI TAKEMOTO, MICHIHIRO KUDOU, KATSUTOSHI SHODA, TOMOHIRO ARITA, TOSHIYUKI KOSUGA, RYO MORIMURA, YASUTOSHI MURAYAMA, YOSHIAKI KURIU, HISASHI IKOMA, TAKESHI KUBOTA, MASAYOSHI NAKANISHI, KAZUMA OKAMOTO and EIGO OTSUJI

  Anticancer Research August 2018, 38 (8) 4941-4945; DOI: https://doi.org/10.21873/anticanres.12811
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  A Bi-national Analysis of 252 Pancreatic Resections for Chronic Pancreatitis with Regard to Incidental Carcinoma Sequence and Overall Postoperative Outcome

  THOMAS MALINKA, FRITZ KLEIN, TRANG LE THU, CHRISTINA S. RÖSCH, HELWIG WUNDSAM, MATTHIAS BIEBL, JOHANN PRATSCHKE, MARCUS BAHRA and REINHOLD FÜGGER

  Anticancer Research August 2018, 38 (8) 4947-4952; DOI: https://doi.org/10.21873/anticanres.12812
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  Quality of Life and Radiation-induced Late Toxicity Following Intensity-modulated Versus Three-dimensional Conformal Radiotherapy for Patients with Spinal Bone Metastases: Results of a Randomized Trial

  TANJA SPRAVE, VIVEK VERMA, ROBERT FÖRSTER, INGMAR SCHLAMPP, KATHARINA HEES, THOMAS BRUCKNER, TILMAN BOSTEL, RAMI EL SHAFIE, NILS HENRIK NICOLAY, JÜRGEN DEBUS and HARALD RIEF

  Anticancer Research August 2018, 38 (8) 4953-4960; DOI: https://doi.org/10.21873/anticanres.12813
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  Quality of Life Following Stereotactic Body Radiotherapy Versus Three-Dimensional Conformal Radiotherapy for Vertebral Metastases: Secondary Analysis of an Exploratory Phase II Randomized Trial

  TANJA SPRAVE, VIVEK VERMA, ROBERT FÖRSTER, INGMAR SCHLAMPP, THOMAS BRUCKNER, TILMAN BOSTEL, RAMI ATEAYH EL SHAFIE, NILS HENRIK NICOLAY, JÜRGEN DEBUS and HARALD RIEF

  Anticancer Research August 2018, 38 (8) 4961-4968; DOI: https://doi.org/10.21873/anticanres.12814