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Research ArticlePROCEEDINGS OF THE 21st ANNUAL MEETING OF THE SOCIETY OF BIOTHERAPEUTIC APPROACHES

Possible Application of Ascites-infiltrating Gamma-delta T Cells for Adoptive Immunotherapy

YUKI ABE, HIROHITO KOBAYASHI, YOSHIKA AKIZAWA, KEN ISHITANI, KAZUNORI HASHIMOTO and HIDEO MATSUI
Anticancer Research July 2018, 38 (7) 4327-4331; DOI: https://doi.org/10.21873/anticanres.12732
YUKI ABE
1Department of Obstetrics and Gynecology, Tokyo Women's Medical University, Tokyo, Japan
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HIROHITO KOBAYASHI
2Department of Transfusion Medicine and Cell Processing, Tokyo Women's Medical University, Tokyo, Japan
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YOSHIKA AKIZAWA
1Department of Obstetrics and Gynecology, Tokyo Women's Medical University, Tokyo, Japan
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KEN ISHITANI
3Department of Gynecology, Kitasato University Kitasato Institute Hospital, Tokyo, Japan
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KAZUNORI HASHIMOTO
1Department of Obstetrics and Gynecology, Tokyo Women's Medical University, Tokyo, Japan
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  • For correspondence: hashimoto.kazunori@twmu.ac.jp
HIDEO MATSUI
1Department of Obstetrics and Gynecology, Tokyo Women's Medical University, Tokyo, Japan
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Abstract

Background/Aim: Malignant ascites contain many tumour-infiltrating lymphocytes. γδ T cells with antitumour activity have attracted attention as effector cells in cancer immunotherapy. Vδ2+ T cells were cultured from peripheral blood mononuclear cells (PBMCs) and ascites-infiltrating lymphocytes (AILs) to compare the differences in response to 2-methyl-3-butenyl-1-pyrophosphate (2M3B1-PP) and zoledronate (Zol) as antigens in vitro. Materials and Methods: To expand Vδ2+ T cells from PBMCs and AILs from 29 patients with cancer, these cells were cultured and subjected to analysis. Results: The proliferation rate of Vδ2+ T cells was higher in both PBMCs and AILs when cultured with Zol than with 2M3B1-PP. Although Vδ2+ T cells show a higher rate of expansion in AILs compared to PBMCs, the number of mixed tumour cells in ascites was decreased when cultured with Zol. Conclusion: Vδ2+ T cells in AILs are cytotoxic to tumour cells in ascites and may be considered in adoptive immunotherapy.

  • γδ T cells
  • ovarian cancer
  • ascites
  • tumour-infiltrating lymphocytes
  • ascites-infiltrating lymphocytes
  • Received April 11, 2018.
  • Revision received May 21, 2018.
  • Accepted May 23, 2018.
  • Copyright© 2018, International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved
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Anticancer Research: 38 (7)
Anticancer Research
Vol. 38, Issue 7
July 2018
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Possible Application of Ascites-infiltrating Gamma-delta T Cells for Adoptive Immunotherapy
YUKI ABE, HIROHITO KOBAYASHI, YOSHIKA AKIZAWA, KEN ISHITANI, KAZUNORI HASHIMOTO, HIDEO MATSUI
Anticancer Research Jul 2018, 38 (7) 4327-4331; DOI: 10.21873/anticanres.12732

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Possible Application of Ascites-infiltrating Gamma-delta T Cells for Adoptive Immunotherapy
YUKI ABE, HIROHITO KOBAYASHI, YOSHIKA AKIZAWA, KEN ISHITANI, KAZUNORI HASHIMOTO, HIDEO MATSUI
Anticancer Research Jul 2018, 38 (7) 4327-4331; DOI: 10.21873/anticanres.12732
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Keywords

  • γδ T cells
  • Ovarian cancer
  • ascites
  • tumour-infiltrating lymphocytes
  • ascites-infiltrating lymphocytes
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