Radiosensitizing Effect of 5-Aminolevulinic Acid and Protoporphyrin IX on Carbon-ion Beam Irradiation

TOMOKO KANEKO; MASAHIDE TOMINAGA; RISA KOUZAKI; AYAKA HANYU; KAZUKI UESHIMA; HISATSUGU YAMADA; MASAKI SUGA; TOMOHIRO YAMASHITA; TOMOAKI OKIMOTO; YOSHIHIRO UTO

doi:10.21873/anticanres.12730

Research ArticlePROCEEDINGS OF THE 21st ANNUAL MEETING OF THE SOCIETY OF BIOTHERAPEUTIC APPROACHES

Radiosensitizing Effect of 5-Aminolevulinic Acid and Protoporphyrin IX on Carbon-ion Beam Irradiation

TOMOKO KANEKO, MASAHIDE TOMINAGA, RISA KOUZAKI, AYAKA HANYU, KAZUKI UESHIMA, HISATSUGU YAMADA, MASAKI SUGA, TOMOHIRO YAMASHITA, TOMOAKI OKIMOTO and YOSHIHIRO UTO

Anticancer Research July 2018, 38 (7) 4313-4317; DOI: https://doi.org/10.21873/anticanres.12730

TOMOKO KANEKO

1SAGA Heavy Ion Medical Accelerator in Tosu, Tosu, Japan

2Graduate School of Technology, Industrial and Social Sciences, Tokushima University, Tokushima, Japan

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MASAHIDE TOMINAGA

3Graduate School of Biomedical Sciences, Tokushima University, Tokushima, Japan

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For correspondence: uto.yoshihiro{at}tokushima-u.ac.jp tominaga{at}tokushima-u.ac.jp

RISA KOUZAKI

2Graduate School of Technology, Industrial and Social Sciences, Tokushima University, Tokushima, Japan

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AYAKA HANYU

2Graduate School of Technology, Industrial and Social Sciences, Tokushima University, Tokushima, Japan

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KAZUKI UESHIMA

2Graduate School of Technology, Industrial and Social Sciences, Tokushima University, Tokushima, Japan

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HISATSUGU YAMADA

2Graduate School of Technology, Industrial and Social Sciences, Tokushima University, Tokushima, Japan

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MASAKI SUGA

4Hyogo Ion Beam Medical Center, Tatsuno, Japan

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TOMOHIRO YAMASHITA

4Hyogo Ion Beam Medical Center, Tatsuno, Japan

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TOMOAKI OKIMOTO

4Hyogo Ion Beam Medical Center, Tatsuno, Japan

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YOSHIHIRO UTO

2Graduate School of Technology, Industrial and Social Sciences, Tokushima University, Tokushima, Japan

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For correspondence: uto.yoshihiro{at}tokushima-u.ac.jp tominaga{at}tokushima-u.ac.jp

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Figure 1.
Radiosensitizing activity of ALA and PpIX on carbon-ion beam. C: Control; A: ALA; P: PpIX. Each experiment was performed three times; data are the mean±SD (*p<0.05).
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Figure 2.
Production of mitochondrial ROS by combination of carbon beam with ALA or PpIX. Each experiment was performed three times; data are the mean±SD (*p<0.05).
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Figure 3.
DNA double-strand breaks by combination of carbon beam with ALA or PpIX. Each experiment was performed three times; data are the mean±SD (*p<0.05).
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Figure 4.
Localization of intracellular PpIX. Mitotracker: Mitochondria; Hoechst33342: nucleus.

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Radiosensitizing Effect of 5-Aminolevulinic Acid and Protoporphyrin IX on Carbon-ion Beam Irradiation

TOMOKO KANEKO, MASAHIDE TOMINAGA, RISA KOUZAKI, AYAKA HANYU, KAZUKI UESHIMA, HISATSUGU YAMADA, MASAKI SUGA, TOMOHIRO YAMASHITA, TOMOAKI OKIMOTO, YOSHIHIRO UTO

Anticancer Research Jul 2018, 38 (7) 4313-4317; DOI: 10.21873/anticanres.12730

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Radiosensitizing Effect of 5-Aminolevulinic Acid and Protoporphyrin IX on Carbon-ion Beam Irradiation

TOMOKO KANEKO, MASAHIDE TOMINAGA, RISA KOUZAKI, AYAKA HANYU, KAZUKI UESHIMA, HISATSUGU YAMADA, MASAKI SUGA, TOMOHIRO YAMASHITA, TOMOAKI OKIMOTO, YOSHIHIRO UTO

Anticancer Research Jul 2018, 38 (7) 4313-4317; DOI: 10.21873/anticanres.12730

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Keywords

5-aminolevulinic acid
protoporphyrin IX
carbon-ion beam
reactive oxygen species
mitochondria

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Radiosensitizing Effect of 5-Aminolevulinic Acid and Protoporphyrin IX on Carbon-ion Beam Irradiation

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