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Research ArticlePROCEEDINGS OF THE 21st ANNUAL MEETING OF THE SOCIETY OF BIOTHERAPEUTIC APPROACHES

Radiosensitizing Effect of 5-Aminolevulinic Acid and Protoporphyrin IX on Carbon-ion Beam Irradiation

TOMOKO KANEKO, MASAHIDE TOMINAGA, RISA KOUZAKI, AYAKA HANYU, KAZUKI UESHIMA, HISATSUGU YAMADA, MASAKI SUGA, TOMOHIRO YAMASHITA, TOMOAKI OKIMOTO and YOSHIHIRO UTO
Anticancer Research July 2018, 38 (7) 4313-4317; DOI: https://doi.org/10.21873/anticanres.12730
TOMOKO KANEKO
1SAGA Heavy Ion Medical Accelerator in Tosu, Tosu, Japan
2Graduate School of Technology, Industrial and Social Sciences, Tokushima University, Tokushima, Japan
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MASAHIDE TOMINAGA
3Graduate School of Biomedical Sciences, Tokushima University, Tokushima, Japan
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  • For correspondence: uto.yoshihiro{at}tokushima-u.ac.jp tominaga{at}tokushima-u.ac.jp
RISA KOUZAKI
2Graduate School of Technology, Industrial and Social Sciences, Tokushima University, Tokushima, Japan
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AYAKA HANYU
2Graduate School of Technology, Industrial and Social Sciences, Tokushima University, Tokushima, Japan
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KAZUKI UESHIMA
2Graduate School of Technology, Industrial and Social Sciences, Tokushima University, Tokushima, Japan
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HISATSUGU YAMADA
2Graduate School of Technology, Industrial and Social Sciences, Tokushima University, Tokushima, Japan
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MASAKI SUGA
4Hyogo Ion Beam Medical Center, Tatsuno, Japan
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TOMOHIRO YAMASHITA
4Hyogo Ion Beam Medical Center, Tatsuno, Japan
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TOMOAKI OKIMOTO
4Hyogo Ion Beam Medical Center, Tatsuno, Japan
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YOSHIHIRO UTO
2Graduate School of Technology, Industrial and Social Sciences, Tokushima University, Tokushima, Japan
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  • For correspondence: uto.yoshihiro{at}tokushima-u.ac.jp tominaga{at}tokushima-u.ac.jp
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Article Information

vol. 38 no. 7 4313-4317
DOI 
https://doi.org/10.21873/anticanres.12730
PMID 
29970567

Published By 
International Institute of Anticancer Research
Print ISSN 
0250-7005
Online ISSN 
1791-7530
History 
  • Received April 11, 2018
  • Revision received May 14, 2018
  • Accepted May 15, 2018
  • Published online July 3, 2018.

Copyright & Usage 
Copyright© 2018, International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved

Author Information

  1. TOMOKO KANEKO1,2,
  2. MASAHIDE TOMINAGA3⇑,
  3. RISA KOUZAKI2,
  4. AYAKA HANYU2,
  5. KAZUKI UESHIMA2,
  6. HISATSUGU YAMADA2,
  7. MASAKI SUGA4,
  8. TOMOHIRO YAMASHITA4,
  9. TOMOAKI OKIMOTO4 and
  10. YOSHIHIRO UTO2⇑
  1. 1SAGA Heavy Ion Medical Accelerator in Tosu, Tosu, Japan
  2. 2Graduate School of Technology, Industrial and Social Sciences, Tokushima University, Tokushima, Japan
  3. 3Graduate School of Biomedical Sciences, Tokushima University, Tokushima, Japan
  4. 4Hyogo Ion Beam Medical Center, Tatsuno, Japan
  1. Correspondence to: Dr. Yoshihiro Uto, Graduate School of Technology, Industrial and Social Sciences, Tokushima University, 2-1 Minamijosanjima-cho, Tokushima, 770-8506, Japan. Tel/Fax: +81 886567514, e-mail: uto.yoshihiro{at}tokushima-u.ac.jp; Dr. Masahide Tominaga, Graduate School of Biomedical Sciences, Tokushima University, 3-18-15 Kuramoto-cho, Tokushima, 770-8503, Japan. Tel: +81 886339863, e-mail: tominaga{at}tokushima-u.ac.jp
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Radiosensitizing Effect of 5-Aminolevulinic Acid and Protoporphyrin IX on Carbon-ion Beam Irradiation
TOMOKO KANEKO, MASAHIDE TOMINAGA, RISA KOUZAKI, AYAKA HANYU, KAZUKI UESHIMA, HISATSUGU YAMADA, MASAKI SUGA, TOMOHIRO YAMASHITA, TOMOAKI OKIMOTO, YOSHIHIRO UTO
Anticancer Research Jul 2018, 38 (7) 4313-4317; DOI: 10.21873/anticanres.12730

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Radiosensitizing Effect of 5-Aminolevulinic Acid and Protoporphyrin IX on Carbon-ion Beam Irradiation
TOMOKO KANEKO, MASAHIDE TOMINAGA, RISA KOUZAKI, AYAKA HANYU, KAZUKI UESHIMA, HISATSUGU YAMADA, MASAKI SUGA, TOMOHIRO YAMASHITA, TOMOAKI OKIMOTO, YOSHIHIRO UTO
Anticancer Research Jul 2018, 38 (7) 4313-4317; DOI: 10.21873/anticanres.12730
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Keywords

  • 5-aminolevulinic acid
  • protoporphyrin IX
  • carbon-ion beam
  • reactive oxygen species
  • mitochondria
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