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Research ArticleClinical Studies

A Panel of Biomarkers for Diagnosis of Prostate Cancer Using Urine Samples

JINAN GUO, JIANGGEN YANG, XUHUI ZHANG, XIAOYAN FENG, HEQIU ZHANG, LINGWU CHEN, HEATHER JOHNSON, JENNY L. PERSSON and KEFENG XIAO
Anticancer Research March 2018, 38 (3) 1471-1477;
JINAN GUO
1Department of Urology, The Second Clinical Medical College of Jinan University (Shenzhen People's Hospital), Shenzhen Urology Minimally Invasive Engineering Center, Shenzhen, P.R. China
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JIANGGEN YANG
1Department of Urology, The Second Clinical Medical College of Jinan University (Shenzhen People's Hospital), Shenzhen Urology Minimally Invasive Engineering Center, Shenzhen, P.R. China
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XUHUI ZHANG
2Department of Bio-diagnosis, Institute of Basic Medical Sciences, Beijing, P.R. China
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XIAOYAN FENG
2Department of Bio-diagnosis, Institute of Basic Medical Sciences, Beijing, P.R. China
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HEQIU ZHANG
2Department of Bio-diagnosis, Institute of Basic Medical Sciences, Beijing, P.R. China
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LINGWU CHEN
3Department of Urology, The First Affiliated Hospital of Sun Yat-Sen University, Guangzhou, P.R. China
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HEATHER JOHNSON
4Olympia Diagnostics, Inc., Sunnyvale, CA, U.S.A.
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JENNY L. PERSSON
5Department of Translational Medicine, Lund University, Malmö, Sweden
6Department of Molecular Biology, Umeå University, Umeå, Sweden
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  • For correspondence: jenny_l.persson@med.lu.se kevin5510315@qq.com
KEFENG XIAO
1Department of Urology, The Second Clinical Medical College of Jinan University (Shenzhen People's Hospital), Shenzhen Urology Minimally Invasive Engineering Center, Shenzhen, P.R. China
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  • For correspondence: jenny_l.persson@med.lu.se kevin5510315@qq.com
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    Figure 1.

    Box plots of gene-expression levels (relative to β-actin) of six biomarkers as well as their combination from a cohort of 154 specimens from patients with prostate cancer (PCa) and those with benign prostate disease (Non-PCa). Mann–Whitney U-test was conducted to calculate p-values for each biomarker and their combination as shown. A: MYO6; B: HPN; C: GSTP1; D: LMTK2; E: FN1; F: CCND1; G: combination of 6-biomarker panel.

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    Figure 2.

    Receiver operating characteristic curve for the 6-biomarker panel for diagnosis of prostate cancer using urine cell samples. The area under the curve was 0.803.

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    Figure 3.

    Receiver operating characteristic curve for serum prostate-specific antigen at 4 ng/ml cutoff for diagnosis of prostate cancer. The area under the curve was 0.521.

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Anticancer Research: 38 (3)
Anticancer Research
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March 2018
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A Panel of Biomarkers for Diagnosis of Prostate Cancer Using Urine Samples
JINAN GUO, JIANGGEN YANG, XUHUI ZHANG, XIAOYAN FENG, HEQIU ZHANG, LINGWU CHEN, HEATHER JOHNSON, JENNY L. PERSSON, KEFENG XIAO
Anticancer Research Mar 2018, 38 (3) 1471-1477;

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A Panel of Biomarkers for Diagnosis of Prostate Cancer Using Urine Samples
JINAN GUO, JIANGGEN YANG, XUHUI ZHANG, XIAOYAN FENG, HEQIU ZHANG, LINGWU CHEN, HEATHER JOHNSON, JENNY L. PERSSON, KEFENG XIAO
Anticancer Research Mar 2018, 38 (3) 1471-1477;
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