Research ArticleExperimental Studies

Curcumin and Rutin Down-regulate Cyclooxygenase-2 and Reduce Tumor-associated Inflammation in HPV16-Transgenic Mice

MAGDA S.S. MOUTINHO, SOFIA ARAGÃO, DIOGO CARMO, FÁTIMA CASACA, SANDRA SILVA, JOANA RIBEIRO, HUGO SOUSA, ISABEL PIRES, FELISBINA QUEIROGA, BRUNO COLAÇO, RUI MEDEIROS, PAULA A. OLIVEIRA, CARLOS LOPES, MARGARIDA M.S.M. BASTOS and RUI M. GIL DA COSTA
Anticancer Research March 2018, 38 (3) 1461-1466;

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Figures

  • Figure 1.
    Figure 1.

    Histopathological changes induced by HPV16 in FVB/n mice, hematoxylin-eosin staining. a: Normal skin histology (group 1 animal), ×40. b: Epidermal hyperplasia and papillomatosis (group 2 animal), ×100. c: Epidermal dysplasia (group 2 animal), ×100.

  • Figure 2.
    Figure 2.

    Cycle-oxygenase-2 (COX2) immunoexpression in experimental mice, diaminobenzidine-Mayer's hematoxylin staining. a: Wild-type mouse (group 1). COX2 expression limited to scattered dermal leukocytes, ×40. b: Untreated HPV16-transgenic mouse (group 2). Intense diffuse dermal and epidermal COX2 immunoexpression, ×100. c: Rutin-treated HPV16-transgenic mouse (group 3). Light to moderate, multifocal COX2 immunoexpression in the dermis and epidermis, ×40. d: Curcumin-treated HPV16-transgenic mouse (group 4). Light, multifocal COX2 immunoexpression epidermis, but intense diffuse immunoexpression in the dermis, ×40.

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Curcumin and Rutin Down-regulate Cyclooxygenase-2 and Reduce Tumor-associated Inflammation in HPV16-Transgenic Mice
MAGDA S.S. MOUTINHO, SOFIA ARAGÃO, DIOGO CARMO, FÁTIMA CASACA, SANDRA SILVA, JOANA RIBEIRO, HUGO SOUSA, ISABEL PIRES, FELISBINA QUEIROGA, BRUNO COLAÇO, RUI MEDEIROS, PAULA A. OLIVEIRA, CARLOS LOPES, MARGARIDA M.S.M. BASTOS, RUI M. GIL DA COSTA
Anticancer Research Mar 2018, 38 (3) 1461-1466;
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