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Research ArticleExperimental Studies

Curcumin and Rutin Down-regulate Cyclooxygenase-2 and Reduce Tumor-associated Inflammation in HPV16-Transgenic Mice

MAGDA S.S. MOUTINHO, SOFIA ARAGÃO, DIOGO CARMO, FÁTIMA CASACA, SANDRA SILVA, JOANA RIBEIRO, HUGO SOUSA, ISABEL PIRES, FELISBINA QUEIROGA, BRUNO COLAÇO, RUI MEDEIROS, PAULA A. OLIVEIRA, CARLOS LOPES, MARGARIDA M.S.M. BASTOS and RUI M. GIL DA COSTA
Anticancer Research March 2018, 38 (3) 1461-1466;
MAGDA S.S. MOUTINHO
1Center for the Research and Technology of Agro-Environmental and Biological Sciences, University of Trás-os-Montes and Alto Douro, Vila Real, Portugal
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  • For correspondence: magdamoutinho@hotmail.com
SOFIA ARAGÃO
1Center for the Research and Technology of Agro-Environmental and Biological Sciences, University of Trás-os-Montes and Alto Douro, Vila Real, Portugal
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DIOGO CARMO
2Botelho Moniz Análises Clínicas, Porto, Portugal
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FÁTIMA CASACA
2Botelho Moniz Análises Clínicas, Porto, Portugal
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SANDRA SILVA
2Botelho Moniz Análises Clínicas, Porto, Portugal
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JOANA RIBEIRO
3Molecular Oncology and Viral Pathology Group, IPO-Porto Research Center, Portuguese Institute of Oncology of Porto, Porto, Portugal
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HUGO SOUSA
3Molecular Oncology and Viral Pathology Group, IPO-Porto Research Center, Portuguese Institute of Oncology of Porto, Porto, Portugal
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ISABEL PIRES
4Department of Veterinary Sciences, University of Trás-os-Montes and Alto Douro, Vila Real, Portugal
5Animal and Veterinary Research Center–Department of Veterinary Sciences, University of Trás-os-Montes and Alto Douro, Vila Real, Portugal
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FELISBINA QUEIROGA
1Center for the Research and Technology of Agro-Environmental and Biological Sciences, University of Trás-os-Montes and Alto Douro, Vila Real, Portugal
4Department of Veterinary Sciences, University of Trás-os-Montes and Alto Douro, Vila Real, Portugal
6Center for the Study of Animal Science, University of Porto, Porto, Portugal
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BRUNO COLAÇO
1Center for the Research and Technology of Agro-Environmental and Biological Sciences, University of Trás-os-Montes and Alto Douro, Vila Real, Portugal
7Zootechnics Department, University of Trás-os-Montes and Alto Douro, Vila Real, Portugal
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RUI MEDEIROS
3Molecular Oncology and Viral Pathology Group, IPO-Porto Research Center, Portuguese Institute of Oncology of Porto, Porto, Portugal
8Faculty of Medicine, University of Porto, Porto, Portugal
9Center for Biomedical Research, Faculty of Health Sciences, Fernando Pessoa University, Porto, Portugal
10Portuguese League Against Cancer, Research Department (NRNorte), Porto, Portugal
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PAULA A. OLIVEIRA
1Center for the Research and Technology of Agro-Environmental and Biological Sciences, University of Trás-os-Montes and Alto Douro, Vila Real, Portugal
4Department of Veterinary Sciences, University of Trás-os-Montes and Alto Douro, Vila Real, Portugal
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CARLOS LOPES
2Botelho Moniz Análises Clínicas, Porto, Portugal
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MARGARIDA M.S.M. BASTOS
11Laboratory for Process Engineering Environment Biotechnology and Energy (LEPABE) Chemical Engineering Department, Faculty of Engineering, University of Porto, Porto, Portugal
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RUI M. GIL DA COSTA
1Center for the Research and Technology of Agro-Environmental and Biological Sciences, University of Trás-os-Montes and Alto Douro, Vila Real, Portugal
3Molecular Oncology and Viral Pathology Group, IPO-Porto Research Center, Portuguese Institute of Oncology of Porto, Porto, Portugal
11Laboratory for Process Engineering Environment Biotechnology and Energy (LEPABE) Chemical Engineering Department, Faculty of Engineering, University of Porto, Porto, Portugal
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Article Information

vol. 38 no. 3 1461-1466
PubMed 
29491072

Published By 
International Institute of Anticancer Research
Print ISSN 
0250-7005
Online ISSN 
1791-7530
History 
  • Received December 30, 2017
  • Revision received January 25, 2018
  • Accepted January 30, 2018
  • Published online February 28, 2018.

Copyright & Usage 
Copyright© 2018, International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved

Author Information

  1. MAGDA S.S. MOUTINHO1⇑,
  2. SOFIA ARAGÃO1,
  3. DIOGO CARMO2,
  4. FÁTIMA CASACA2,
  5. SANDRA SILVA2,
  6. JOANA RIBEIRO3,
  7. HUGO SOUSA3,
  8. ISABEL PIRES4,5,
  9. FELISBINA QUEIROGA1,4,6,
  10. BRUNO COLAÇO1,7,
  11. RUI MEDEIROS3,8,9,10,
  12. PAULA A. OLIVEIRA1,4,
  13. CARLOS LOPES2,
  14. MARGARIDA M.S.M. BASTOS11 and
  15. RUI M. GIL DA COSTA1,3,11
  1. 1Center for the Research and Technology of Agro-Environmental and Biological Sciences, University of Trás-os-Montes and Alto Douro, Vila Real, Portugal
  2. 2Botelho Moniz Análises Clínicas, Porto, Portugal
  3. 3Molecular Oncology and Viral Pathology Group, IPO-Porto Research Center, Portuguese Institute of Oncology of Porto, Porto, Portugal
  4. 4Department of Veterinary Sciences, University of Trás-os-Montes and Alto Douro, Vila Real, Portugal
  5. 5Animal and Veterinary Research Center–Department of Veterinary Sciences, University of Trás-os-Montes and Alto Douro, Vila Real, Portugal
  6. 6Center for the Study of Animal Science, University of Porto, Porto, Portugal
  7. 7Zootechnics Department, University of Trás-os-Montes and Alto Douro, Vila Real, Portugal
  8. 8Faculty of Medicine, University of Porto, Porto, Portugal
  9. 9Center for Biomedical Research, Faculty of Health Sciences, Fernando Pessoa University, Porto, Portugal
  10. 10Portuguese League Against Cancer, Research Department (NRNorte), Porto, Portugal
  11. 11Laboratory for Process Engineering Environment Biotechnology and Energy (LEPABE) Chemical Engineering Department, Faculty of Engineering, University of Porto, Porto, Portugal
  1. Correspondence to: Magda Moutinho, Center for the Research and Technology of Agro-Environmental and Biological Sciences, University of Trás-os-Montes and Alto Douro, Quinta de Prados, Vila Real, Portugal. Tel: +351 259350000, Fax: +351 259350480, e-mail: magdamoutinho{at}hotmail.com
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Anticancer Research: 38 (3)
Anticancer Research
Vol. 38, Issue 3
March 2018
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Curcumin and Rutin Down-regulate Cyclooxygenase-2 and Reduce Tumor-associated Inflammation in HPV16-Transgenic Mice
MAGDA S.S. MOUTINHO, SOFIA ARAGÃO, DIOGO CARMO, FÁTIMA CASACA, SANDRA SILVA, JOANA RIBEIRO, HUGO SOUSA, ISABEL PIRES, FELISBINA QUEIROGA, BRUNO COLAÇO, RUI MEDEIROS, PAULA A. OLIVEIRA, CARLOS LOPES, MARGARIDA M.S.M. BASTOS, RUI M. GIL DA COSTA
Anticancer Research Mar 2018, 38 (3) 1461-1466;

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Curcumin and Rutin Down-regulate Cyclooxygenase-2 and Reduce Tumor-associated Inflammation in HPV16-Transgenic Mice
MAGDA S.S. MOUTINHO, SOFIA ARAGÃO, DIOGO CARMO, FÁTIMA CASACA, SANDRA SILVA, JOANA RIBEIRO, HUGO SOUSA, ISABEL PIRES, FELISBINA QUEIROGA, BRUNO COLAÇO, RUI MEDEIROS, PAULA A. OLIVEIRA, CARLOS LOPES, MARGARIDA M.S.M. BASTOS, RUI M. GIL DA COSTA
Anticancer Research Mar 2018, 38 (3) 1461-1466;
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