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Research ArticleExperimental Studies

Oolong Tea Extract Induces DNA Damage and Cleavage and Inhibits Breast Cancer Cell Growth and Tumorigenesis

HAIHONG SHI, JIN LIU, YIFAN TU, CARL E. FRETER and CHUNFA HUANG
Anticancer Research November 2018, 38 (11) 6217-6223; DOI: https://doi.org/10.21873/anticanres.12976
HAIHONG SHI
1Department of Oncology, The Second Affiliated Hospital of Fujian Medical University, Quanzhou, P.R. China
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JIN LIU
2Division of Hematology/Oncology, Department of Internal Medicine, School of Medicine, Saint Louis University, Saint Louis, MO, U.S.A.
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YIFAN TU
2Division of Hematology/Oncology, Department of Internal Medicine, School of Medicine, Saint Louis University, Saint Louis, MO, U.S.A.
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CARL E. FRETER
2Division of Hematology/Oncology, Department of Internal Medicine, School of Medicine, Saint Louis University, Saint Louis, MO, U.S.A.
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CHUNFA HUANG
2Division of Hematology/Oncology, Department of Internal Medicine, School of Medicine, Saint Louis University, Saint Louis, MO, U.S.A.
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  • For correspondence: chunfa.huang@health.slu.edu
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Abstract

Background/Aim: Breast cancer is the most prevalent and devastating malignant disease among women worldwide. Green tea has been extensively studied for its anti-cancer effects, however, existing literature on the correlation of other types of tea with breast cancer is very limited. Materials and Methods: We used six different breast cancer cell lines (ER+, PR+ or HER2+ and triple-negative), treated under different concentrations of green, oolong, black and dark tea extracts, and determined their biological effects. Results: We determined cell viability, observed the changes of cell morphology, measured DNA damage and cleavage, and analyzed the effect on soft agar colony formation and growth. Conclusion: Oolong tea, same as green tea, can induce DNA damage and cleavage, play an inhibitory role in breast cancer cell growth, proliferation and tumorigenesis, and was a great potential as a chemo-preventive agent against breast cancer.

  • Oolong tea
  • breast cancer
  • cell viability
  • DNA damage and cleavage
  • soft agar colony formation
  • Received September 10, 2018.
  • Revision received October 16, 2018.
  • Accepted October 19, 2018.
  • Copyright© 2018, International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved
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Anticancer Research: 38 (11)
Anticancer Research
Vol. 38, Issue 11
November 2018
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Oolong Tea Extract Induces DNA Damage and Cleavage and Inhibits Breast Cancer Cell Growth and Tumorigenesis
HAIHONG SHI, JIN LIU, YIFAN TU, CARL E. FRETER, CHUNFA HUANG
Anticancer Research Nov 2018, 38 (11) 6217-6223; DOI: 10.21873/anticanres.12976

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Oolong Tea Extract Induces DNA Damage and Cleavage and Inhibits Breast Cancer Cell Growth and Tumorigenesis
HAIHONG SHI, JIN LIU, YIFAN TU, CARL E. FRETER, CHUNFA HUANG
Anticancer Research Nov 2018, 38 (11) 6217-6223; DOI: 10.21873/anticanres.12976
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Keywords

  • Oolong tea
  • Breast cancer
  • cell viability
  • DNA damage and cleavage
  • soft agar colony formation
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