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Research ArticleExperimental Studies

Oncolytic Properties of Ampakines In Vitro

DANIEL P. RADIN, RICHARD PURCELL and ARNOLD S. LIPPA
Anticancer Research January 2018, 38 (1) 265-269;
DANIEL P. RADIN
RespireRx Pharmaceuticals, Inc., Glen Rock, NJ, U.S.A.
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  • For correspondence: dradin@respirerx.com
RICHARD PURCELL
RespireRx Pharmaceuticals, Inc., Glen Rock, NJ, U.S.A.
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ARNOLD S. LIPPA
RespireRx Pharmaceuticals, Inc., Glen Rock, NJ, U.S.A.
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    Figure 1.

    FLX is oncolytic in multiple cancers. Dose response curve of FLX in U87, Panc1 and HT29 cells. Data are presented as mean±SEM of 3-5 independent experiments performed in quadruplicate. ANOVA, p<0.001, followed by t-test where **p<0.01, ***p<0.001, compared to vehicle-treated control.

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    Figure 2.

    CX614 is oncolytic in multiple cancers. Dose response curve of CX614 in U87, Panc1 and HT29 cells. Data are presented as mean±SEM of 3-4 independent experiments performed in quadruplicate. ANOVA, p<0.01, followed by t-test where *p<0.05, **p<0.01, compared to vehicle-treated control.

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    Figure 3.

    CX614 enhances FLX's oncolytic effects. FLX and CX614 synergistically reduce A) U87, B) Panc1 and C) HT29 cell viability. Data are presented as mean±SEM of 3-4 independent experiments performed in quadruplicate. T-test where *p<0.05, **p<0.01, compared to vehicle-treated control. #p<0.05, king's synergy test, demonstrating significant synergistic interaction.

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Anticancer Research: 38 (1)
Anticancer Research
Vol. 38, Issue 1
January 2018
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Oncolytic Properties of Ampakines In Vitro
DANIEL P. RADIN, RICHARD PURCELL, ARNOLD S. LIPPA
Anticancer Research Jan 2018, 38 (1) 265-269;

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Oncolytic Properties of Ampakines In Vitro
DANIEL P. RADIN, RICHARD PURCELL, ARNOLD S. LIPPA
Anticancer Research Jan 2018, 38 (1) 265-269;
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