Article Figures & Data
Figures
- Figure 1.
Differential methylation patterns of 5’-C-phosphate-G-3 (CpG) residues in a hypothetical chromosome A’ in the kidney, lung and liver (a) and in normal and cancer cells of the same tissue (b). The black/gray line denotes the chromosome. Green balls are unmethylated CpG residues; red balls are methylated CpG residues. It can be seen that methylation patterns of the same chromosome in the cells of different tissues are different (a). The total amount of methylation is lower in cancer cells compared to normal cells (b). This differential behavior possibly favors growth, promoting gene expression and suppression of tumor-suppressor genes.
- Figure 2.
Differential binding of H3K27me3 and H3K4me3 at different locations in two hypothetical genes A and B in the kidney: The black/gray line denotes the chromosome. The green balls are unmethylated 5’-C-phosphate-G-3 (CpG) residues; red balls are methylated CpG residues. The stop sign on transcription start site (TSS) signifies inhibition of transcription. The stop sign on CpG residues signifies inhibition of binding. Differential binding of these histone markers at methylated (red) or unmethylated (green) sites on DNA regulates the outcome of collective gene expression in some selected predisposed cells of a tissue, which will determine whether they will become cancer progenitor cells. It is a slow, time-consuming process.
