Article Figures & Data
Figures
- Figure 1.
Effect of quercetin on tumor incidence in DMBA-induced hamster buccal pouch (HBP) carcinogenesis. A. Representative images of the HBP in each group. Black arrows indicate tumors. B. Representative histological images of H&E staining of HBP in each group, normal histology in G1 and G2, well differentiated OSCC in G3 and G4, mild hyperplasia in G5 and G6, (100× magnification).
- Figure 2.
Effect of quercetin on tumor apoptosis in DMBA-induced HBP carcinogenesis. A. Representative TUNEL images for apoptosis in each group (100× magnification). B. Quantitation of apoptosis by average optical density (AOD). *p<0.01, compared to G3 DMBA.
- Figure 3.
Effect of quercetin on mRNA expression of NF-κB p50 and p65 in DMBA-induced HBP carcinogenesis. A. NF-κB p50 mRNA expression in each group. B. NF-κB p65 mRNA expression in each group. *p<0.05, when compared to the G1 normal-control group. #p<0.05, when compared with G3, DMBA induction only.
- Figure 4.
Effect of quercetin on protein expression of NF-κB p50 and p65 in DMBA-induced HBP carcinogenesis. A. Representative immunoblots of NF-κB p50 and p65 proteins in each group. B. NF-κB p50 protein expression in each group. C. NF-κB p65 protein expression in each group. **p<0.01, when compared to the G1 normal control group. #p<0.05 and ##p<0.01, when compared to G3, DMBA induction only.
- Figure 5.
Effect of quercetin on mRNA expression of Bcl-2 and Bax in DMBA-induced HBP carcinogenesis. A. Bcl-2 mRNA expression in each group. B. Bax mRNA expression in each group. *p<0.05, compared to the G1 normal control group. #p<0.05 and ##p<0.01, compared to G3, DMBA-induction only.
- Figure 6.
Effect of quercetin on protein expression of Bcl-2 and Bax in DMBA-induced HBP carcinogenesis. A. Representative immunoblots of Bcl-2 and Bax proteins in each group. B. Bcl-2 protein expression in each group. C. Bax protein expression in each group. **p<0.01, when compared to the G1 normal-control group. #p<0.05 and ##p<0.01, compared to G3, DMBA induction only.
- Figure 7.
Effect of quercetin on hamster body weight. Simultaneous treatment with quercetin significantly alleviated body weight loss in DMBA+quercetin groups. *p<0.05, compared to G3 DMBA induction only.
