Vitamin D Receptor Polymorphism and Cancer: An Update

Abstract

Background: Vitamin D mediates its action via vitamin D receptor (VDR) and is involved in a wide variety of biological processes including regulation of cell proliferation and differentiation in normal tissue and apoptosis, and cell adhesion in tumor cells. The study of genetic variations in VDR may elucidate the association of vitamin D levels, its metabolism, and VDR polymorphism with various diseases and cancer. The association of VDR polymorphism with cancer has been reported; however, the literature lacks critical analyses of the studies in last 3 years. Materials and Methods: A systematic search of PubMed database (2015 through mid-2017) was conducted to provide a comprehensive overview of this clinical arena. Results: Studies on the association of VDR polymorphisms FokI, BsmI, TaqI, and ApaI and cancer have suggested the involvement of VDR polymorphism in tumorigenesis. Conclusion: The inconsistent results and lack of the studies in some cancer types warrant additional research.