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Research ArticleClinical Studies

Slow-release L-Cysteine (Acetium®) Lozenge Is an Effective New Method in Smoking Cessation. A Randomized, Double-blind, Placebo-controlled Intervention

KARI SYRJÄNEN, KATJA ERONEN, PANU HENDOLIN, LEA PALOHEIMO, CARITA EKLUND, ANNA BÄCKSTRÖM and OSMO SUOVANIEMI
Anticancer Research July 2017, 37 (7) 3639-3648;
KARI SYRJÄNEN
1Department of Clinical Research, Biohit Oyj, Helsinki, Finland
2Molecular Oncology Research Center, Barretos Cancer Hospital, Barretos, SP, Brazil
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  • For correspondence: kari.syrjanen@biohit.fi
KATJA ERONEN
1Department of Clinical Research, Biohit Oyj, Helsinki, Finland
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PANU HENDOLIN
3Department of Research and Development, Biohit Oyj, Helsinki, Finland
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LEA PALOHEIMO
3Department of Research and Development, Biohit Oyj, Helsinki, Finland
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CARITA EKLUND
3Department of Research and Development, Biohit Oyj, Helsinki, Finland
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ANNA BÄCKSTRÖM
4KUULAS Helsinki/Business Science Helsinki, Helsinki, Finland
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OSMO SUOVANIEMI
1Department of Clinical Research, Biohit Oyj, Helsinki, Finland
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Abstract

Background/Aim: Because of the major health problems and annual economic burden caused by cigarette smoking, effective new tools for smoking intervention are urgently needed. Our previous randomized controlled trial (RCT) provided promising results on the efficacy of slow-release L-cysteine lozenge in smoking intervention, but the study was not adequately powered. To confirm in an adequately-powered study the results of the previous RCT implicating that effective elimination of acetaldehyde in saliva by slow-release L-cysteine (Acetium® lozenge, Biohit Oyj, Helsinki), would assist in smoking cessation by reducing acetaldehyde-enhanced nicotine addiction. On this matter, we undertook a double-blind, randomized, placebo-controlled trial comparing Acetium® lozenge and placebo in smoking intervention. Materials and Methods: A cohort of 1,998 cigarette smokers were randomly allocated to intervention (n=996) and placebo arms (n=1,002). At baseline, smoking history was recorded by a questionnaire, with nicotine dependence testing according to the Fagerström scale (FTND). The subjects used smoking diary recording the daily numbers of cigarettes, lozenges and subjective sensations of smoking. The data were analysed separately for point prevalence of abstinence (PPA) and prolonged abstinence (PA) endpoints. Results: Altogether, 753 study subjects completed the trial per protocol (PP), 944 with violations (mITT), and the rest (n=301) were lost to follow-up (LTF). During the 6-month intervention, 331 subjects stopped smoking; 181 (18.2%) in the intervention arm and 150 (15.0%) in the placebo arm (OR=1.43; 95%CI=1.09-1.88); p=0.010). In the PP group, 170 (45.3%) quitted smoking in the intervention arm compared to 134 (35.4%) in the placebo arm (OR=1.51, 95%CI=1.12-2.02; p=0.006). In multivariate (Poisson regression) model, decreased level of smoking pleasure (p=0.010) and “smoking sensations changed” were powerful independent predictors of quit events (IRR=12.01; 95%CI=1.5-95.6). Conclusion: Acetium® lozenge, herein confirmed in an adequately powered study to be an effective means to aid smoking quit, represents a major breakthrough in the development of smoking intervention methods, because slow-release L-cysteine is non-toxic, with no side-effects or limitations of use.

  • Smoking cessation
  • Acetium® lozenge
  • slow-release|L-cysteine
  • Received May 22, 2017.
  • Revision received May 29, 2017.
  • Accepted May 31, 2017.
  • Copyright© 2017, International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved
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Anticancer Research: 37 (7)
Anticancer Research
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July 2017
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Slow-release L-Cysteine (Acetium®) Lozenge Is an Effective New Method in Smoking Cessation. A Randomized, Double-blind, Placebo-controlled Intervention
KARI SYRJÄNEN, KATJA ERONEN, PANU HENDOLIN, LEA PALOHEIMO, CARITA EKLUND, ANNA BÄCKSTRÖM, OSMO SUOVANIEMI
Anticancer Research Jul 2017, 37 (7) 3639-3648;

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Slow-release L-Cysteine (Acetium®) Lozenge Is an Effective New Method in Smoking Cessation. A Randomized, Double-blind, Placebo-controlled Intervention
KARI SYRJÄNEN, KATJA ERONEN, PANU HENDOLIN, LEA PALOHEIMO, CARITA EKLUND, ANNA BÄCKSTRÖM, OSMO SUOVANIEMI
Anticancer Research Jul 2017, 37 (7) 3639-3648;
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Keywords

  • Smoking cessation
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  • slow-release|L-cysteine
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