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Research ArticleClinical Studies

Low Variability and Stable Frequency of Common Haplotypes of the TP53 Gene Region in Colorectal Cancer Patients in a Slovak Population

MÁRIA ŠKEREŇOVÁ, ERIKA HALAŠOVÁ, TATIANA MATÁKOVÁ, ĽUBICA JESENSKÁ, JANA JUREČEKOVÁ, MIROSLAVA ŠARLINOVÁ, DANIEL ČIERNY and DUŠAN DOBROTA
Anticancer Research April 2017, 37 (4) 1901-1907;
MÁRIA ŠKEREŇOVÁ
1Department of Clinical Biochemistry, University Hospital, Martin, Slovak Republic
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ERIKA HALAŠOVÁ
2Department of Molecular Medicine, Martin Biomedical Centre, Comenius University in Bratislava, Jessenius Faculty of Medicine in Martin, Martin, Slovak Republic
3Department of Medical Biology, Comenius University in Bratislava, Jessenius Faculty of Medicine in Martin, Martin, Slovak Republic
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TATIANA MATÁKOVÁ
2Department of Molecular Medicine, Martin Biomedical Centre, Comenius University in Bratislava, Jessenius Faculty of Medicine in Martin, Martin, Slovak Republic
4Department of Medical Biochemistry, Comenius University in Bratislava, Jessenius Faculty of Medicine in Martin, Martin, Slovak Republic
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  • For correspondence: matakova@jfmed.uniba.sk
ĽUBICA JESENSKÁ
1Department of Clinical Biochemistry, University Hospital, Martin, Slovak Republic
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JANA JUREČEKOVÁ
2Department of Molecular Medicine, Martin Biomedical Centre, Comenius University in Bratislava, Jessenius Faculty of Medicine in Martin, Martin, Slovak Republic
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MIROSLAVA ŠARLINOVÁ
2Department of Molecular Medicine, Martin Biomedical Centre, Comenius University in Bratislava, Jessenius Faculty of Medicine in Martin, Martin, Slovak Republic
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DANIEL ČIERNY
1Department of Clinical Biochemistry, University Hospital, Martin, Slovak Republic
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DUŠAN DOBROTA
1Department of Clinical Biochemistry, University Hospital, Martin, Slovak Republic
4Department of Medical Biochemistry, Comenius University in Bratislava, Jessenius Faculty of Medicine in Martin, Martin, Slovak Republic
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Abstract

Aim: To test the association between common TP53 haplotypes and colorectal cancer (CRC) development. Patients and Methods: A total of 277 CRC patients and 167 healthy volunteers were included in the study. Common TP53 haplotypes were estimated from eight single-nucleotide polymorphisms (SNPs) (rs1614984, rs77697176, rs12947788, rs1800372, rs2909430, rs1042522, rs17878362 and rs11652704). Stepwise haplotype trend regression showed the haplotype-regressor cccgaRDa as a possible predictive marker. Results: The rare haplotype cccgaRDa was identified in 10 CRC cases and 3 controls. Although it is approximately twice as common in CRC (odds ratio (OR)=2.068; 95% confidence interval (CI)=0.471-9.069), the cccgaRDa haplotype frequency is low in the studied groups. Results of our study suggest that the common TP53 variability is relatively low (only 3 haplotypes occurred above 10%). Conclusion: The haplotype background of TP53 gene is relative stable and despite low haplotype-regressor cccgaRDa frequency it shows to be a possible predictive parameter for CRC development.

  • TP53 gene
  • haplotype
  • tagSNP
  • association
  • CRC
  • Received February 1, 2017.
  • Revision received March 3, 2017.
  • Accepted March 6, 2017.
  • Copyright© 2017, International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved
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Low Variability and Stable Frequency of Common Haplotypes of the TP53 Gene Region in Colorectal Cancer Patients in a Slovak Population
MÁRIA ŠKEREŇOVÁ, ERIKA HALAŠOVÁ, TATIANA MATÁKOVÁ, ĽUBICA JESENSKÁ, JANA JUREČEKOVÁ, MIROSLAVA ŠARLINOVÁ, DANIEL ČIERNY, DUŠAN DOBROTA
Anticancer Research Apr 2017, 37 (4) 1901-1907;

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Low Variability and Stable Frequency of Common Haplotypes of the TP53 Gene Region in Colorectal Cancer Patients in a Slovak Population
MÁRIA ŠKEREŇOVÁ, ERIKA HALAŠOVÁ, TATIANA MATÁKOVÁ, ĽUBICA JESENSKÁ, JANA JUREČEKOVÁ, MIROSLAVA ŠARLINOVÁ, DANIEL ČIERNY, DUŠAN DOBROTA
Anticancer Research Apr 2017, 37 (4) 1901-1907;
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Keywords

  • TP53 gene
  • haplotype
  • tagSNP
  • association
  • CRC
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