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Research ArticleExperimental Studies

Alpha-bisabolol Promotes Glioma Cell Death by Modulating the Adenosinergic System

FRANCIANE BRACKMANN MENDES, LETÍCIA SCUSSEL BERGAMIN, CRISTIANE DOS SANTOS STUEPP, ELIZANDRA BRAGANHOL, THATIANA TERROSO, ADRIANA RAFIN POHLMANN, SÍLVIA STANISÇUASKI GUTERRES and ANA MARIA OLIVEIRA BATTASTINI
Anticancer Research April 2017, 37 (4) 1819-1823;
FRANCIANE BRACKMANN MENDES
1Graduate Program in Biological Sciences - Biochemistry, Institute of Basic Health Sciences, Federal University of Rio Grande do Sul, Porto Alegre, Brazil
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LETÍCIA SCUSSEL BERGAMIN
1Graduate Program in Biological Sciences - Biochemistry, Institute of Basic Health Sciences, Federal University of Rio Grande do Sul, Porto Alegre, Brazil
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CRISTIANE DOS SANTOS STUEPP
1Graduate Program in Biological Sciences - Biochemistry, Institute of Basic Health Sciences, Federal University of Rio Grande do Sul, Porto Alegre, Brazil
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ELIZANDRA BRAGANHOL
1Graduate Program in Biological Sciences - Biochemistry, Institute of Basic Health Sciences, Federal University of Rio Grande do Sul, Porto Alegre, Brazil
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THATIANA TERROSO
2Graduate Program in Pharmaceutical Sciences, Faculty of Pharmacy, Federal University of Rio Grande do Sul, Porto Alegre, Brazil
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ADRIANA RAFIN POHLMANN
3Department of Organic Chemistry, Institute of Chemistry, Federal University of Rio Grande do Sul, Porto Alegre, Brazil
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SÍLVIA STANISÇUASKI GUTERRES
2Graduate Program in Pharmaceutical Sciences, Faculty of Pharmacy, Federal University of Rio Grande do Sul, Porto Alegre, Brazil
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ANA MARIA OLIVEIRA BATTASTINI
1Graduate Program in Biological Sciences - Biochemistry, Institute of Basic Health Sciences, Federal University of Rio Grande do Sul, Porto Alegre, Brazil
4Department of Biochemistry, Institute of Basic Health Sciences, Federal University of Rio Grande do Sul, Porto Alegre, Brazil
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  • For correspondence: abattastini@gmail.com
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Abstract

Background/Aim: Glioblastoma multiforme is the most malignant type of glioma. Alpha-bisabolol is an essential oil reported as a potent cell death agent. In the present work, we evaluated the effect of alpha-bisabolol on ecto-5’-nucleotidase/CD73, the most well-characterized enzymatic source of adenosine, present in lipid rafts. Materials and Methods: Glioma cells were treated with alpha-bisabolol and, in some experiments, pre-treated with an A3 antagonist. MTT assay (viability), malachite green method (ecto-5’-nucleotidase/CD73 activity) and quantitative polymerase chain reaction (qPCR) (A3 mRNA) were carried out. Results: Alpha-bisabolol led to a decrease in C6 and U138-MG glioma cells viability, accompanied by an increase in ecto-5’-NT/CD73 activity. Pre-treatment with an A3 antagonist reverted the effect of α-bisabolol with an increase of mRNA expression of this receptor. Conclusion: Our data indicated the participation of ecto-5’-nucleotidase/CD73 and A3 receptor in the anti-proliferative effect of α-bisabolol on glioma cells.

  • Glioma
  • α-bisabolol
  • ecto-5’-NT/CD73
  • adenosine
  • Received January 25, 2017.
  • Revision received March 8, 2017.
  • Accepted March 9, 2017.
  • Copyright© 2017, International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved
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Anticancer Research: 37 (4)
Anticancer Research
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April 2017
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Alpha-bisabolol Promotes Glioma Cell Death by Modulating the Adenosinergic System
FRANCIANE BRACKMANN MENDES, LETÍCIA SCUSSEL BERGAMIN, CRISTIANE DOS SANTOS STUEPP, ELIZANDRA BRAGANHOL, THATIANA TERROSO, ADRIANA RAFIN POHLMANN, SÍLVIA STANISÇUASKI GUTERRES, ANA MARIA OLIVEIRA BATTASTINI
Anticancer Research Apr 2017, 37 (4) 1819-1823;

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Alpha-bisabolol Promotes Glioma Cell Death by Modulating the Adenosinergic System
FRANCIANE BRACKMANN MENDES, LETÍCIA SCUSSEL BERGAMIN, CRISTIANE DOS SANTOS STUEPP, ELIZANDRA BRAGANHOL, THATIANA TERROSO, ADRIANA RAFIN POHLMANN, SÍLVIA STANISÇUASKI GUTERRES, ANA MARIA OLIVEIRA BATTASTINI
Anticancer Research Apr 2017, 37 (4) 1819-1823;
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Keywords

  • Glioma
  • α-Bisabolol
  • ecto-5’-NT/CD73
  • adenosine
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