The Histogenesis of the Third Pathway of Colonic Carcinogenesis in Rats

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Figure 1.
Histological features in colon tissue from dimethylhydrazine-treated Sprague-Dawley rats. Upper panel: Corrupted crypts with asymmetric fission (a, b) or aberrant crypt alignment (c, arrow) in colonic gut-associated lymphoid tissue. Note few or no goblet cells, and absence of conventional dysplasia. Lower panel: Dysplastic corrupted crypts in colonic GALT-mucosa. Note highly differentiated carcinoma evolving from dysplastic corrupted crypts in e and f. Hematoxylin and eosin, a, c, d: ×10; b, e, f: ×20.
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Figure 2.
Histological features in colon tissue from in dimethylhydrazine-treated Sprague-Dawley rats. Upper panel: Highly differentiated carcinomas in colonic gut-associated lymphoid tissue (GALT) mucosa evolving from dysplastic corrupted crypts in a and b. Detail of highly differentiated carcinoma in c. Lower panel: Signet-ring cell carcinoma in colonic GALT mucosa (d), evolving from dysplastic goblet cells present at the base of crypts in e and f. Hematoxylin and eosin, a: ×10; b, d ×4; c, f ×20; e: ×40.