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Research ArticleClinical Studies

Phase II Study of Concurrent Chemoradiotheapy Using Nedaplatin for Locally Advanced Uterine Cervical Carcinoma (KGROG0501): Final Results

YUZURU NIIBE, TAKASHI ONDA, KEITARO MATSUO, YUSUKE INOUE and KAZUSHIGE HAYAKAWA
Anticancer Research December 2017, 37 (12) 6983-6988;
YUZURU NIIBE
1Department of Radiology, Toho University Omori Medical Center, Tokyo, Japan
2Department of Radiology and Radiation Oncology, Kitasato University School of Medicine, Sagamihara, Japan
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  • For correspondence: yniibe-toho{at}umin.org
TAKASHI ONDA
3Department of Obstetrics and Gynecology, Kitasato University School of Medicine, Sagamihara, Japan
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KEITARO MATSUO
4Division of Molecular Medicine, Aichi Cancer Center Research Institute, Nagoya, Japan
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YUSUKE INOUE
5Department of Diagnostic Radiology, Kitasato University School of Medicine, Sagamihara, Japan
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KAZUSHIGE HAYAKAWA
2Department of Radiology and Radiation Oncology, Kitasato University School of Medicine, Sagamihara, Japan
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    Figure 1.

    Kaplan–Meier curve for overall survival (OS) of all registered patients. The median follow-up was 39 months (range=2-87 months). The 3-year OS was 73.0% (95% confidence interval=56.2-84.2%).

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    Figure 2.

    Kaplan–Meier curve for overall survival (OS) stratified by histopathology, The 3-year OS was 81.3% (95% confidence interval=62.7-91.3%) in patients with squamous cell carcinoma (SCC) (n=36) was 44.4% (95% confidence interval=13.6-71.9%) in patients with adenocarcinoma (AC) (n=9). This difference was statistically significant (p=0.0291).

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    Figure 3.

    Kaplan–Meier curve for progression-free survival (PFS) of all registered patients. The 2-year PFS was 71.9% (95% confidence interval=54.9-83.4%) and 3-year PFS was 68.6% (95% confidence interval=51.2-80.4%).

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Anticancer Research
Vol. 37, Issue 12
December 2017
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Phase II Study of Concurrent Chemoradiotheapy Using Nedaplatin for Locally Advanced Uterine Cervical Carcinoma (KGROG0501): Final Results
YUZURU NIIBE, TAKASHI ONDA, KEITARO MATSUO, YUSUKE INOUE, KAZUSHIGE HAYAKAWA
Anticancer Research Dec 2017, 37 (12) 6983-6988;

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Phase II Study of Concurrent Chemoradiotheapy Using Nedaplatin for Locally Advanced Uterine Cervical Carcinoma (KGROG0501): Final Results
YUZURU NIIBE, TAKASHI ONDA, KEITARO MATSUO, YUSUKE INOUE, KAZUSHIGE HAYAKAWA
Anticancer Research Dec 2017, 37 (12) 6983-6988;
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Keywords

  • phase II study
  • Chemoradiotherapy
  • locally advanced uterine cervical carcinoma
  • nedaplatin
  • squamous cell carcinoma
  • Adenocarcinoma
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