Article Figures & Data
Figures
- Figure 1.
Chemical structures of the hydrazonopyrazole derivatives.
- Figure 2.
Hydrazonopyrazole derivatives induced damage in HL-60RG cells. HL-60RG cells were incubated with 100 μM of hydrazonopyrazole derivatives for 24 h (A) or 48 h (B). Cell viability was estimated by MTT assay. The data are presented as a comparison to the untreated control. Each bar denotes the SD (n=4). *p<0.05, **p<0.01, and ***p<0.001 compared to the untreated control groups.
- Figure 3.
3j induced dose-dependent cell damage in HL-60RG cells. HL-60RG cells were incubated with the indicated doses of hydrazonopyrazole derivatives for 24 h. Cell viability was estimated by MTT assay. The data are presented as a comparison to the untreated control. Each bar denotes the SD (n=4). **p<0.01 and ***p<0.001 compared to the untreated control groups.
- Figure 4.
3j fragmented genomic DNA. HL-60RG cells were incubated with the indicated doses of 3j for 24 h. The cells were then lysed and DNA was prepared. DNA fragmentation was analyzed by agarose gel electrophoresis. Data are representative of three independent experiments.
- Figure 5.
Caspase-dependent apoptosis induced by 3j in HL-60RG cells. A: HL-60RG cells were incubated with 100 μM 3j for the indicated times. The cells were then lysed, and caspase-3 was detected by western blotting. Data are representative of three independent experiments. B: HL-60RG cells were incubated with or without 40 μM Z-Asp-CH2-DCB, then 100 μM 3j for 24 h. The cells were then lysed and DNA was prepared. DNA fragmentation was analyzed by agarose gel electrophoresis. Data are representative of three independent experiments.
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