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Review ArticleReviewsR

Anticancer Activity of Artemisinin and its Derivatives

SILVIA SLEZAKOVA and JANA RUDA-KUCEROVA
Anticancer Research November 2017, 37 (11) 5995-6003;
SILVIA SLEZAKOVA
Department of Pharmacology, Faculty of Medicine, Masaryk University, Brno, Czech Republic
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JANA RUDA-KUCEROVA
Department of Pharmacology, Faculty of Medicine, Masaryk University, Brno, Czech Republic
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  • For correspondence: jkucer@med.muni.cz
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Abstract

Artemisinin is an extract from the plant Artemisia annua. With its semi-synthetic derivatives, they form a group of well-known and efficacious antimalarial drugs. Recent studies have documented the potential anticancer effect of artemisinin and its derivatives (ARTs). This review summarizes results of preclinical studies, documenting mechanisms of anticancer actions of ARTs and clinical studies focused mainly on efficacy, safety and dose-ranging of ARTs as anticancer chemotherapeutics. The main mechanisms of action of ARTs is the production of reactive oxygen species, inhibition of cell cycle in G0/G1 phase, induction of apoptosis and inhibition of angiogenesis. Safety studies have shown no evident toxicity and low incidence of adverse effects. ARTs potential to inhibit growth of solid tumours suggests their application in a neoadjuvant therapy. Dihydroartemisinin and artesunate exhibit chemosensitising effects in vivo in breast, lung, pancreas and glioma cancer cells, proposing the use of ARTs also in combination anticancer therapy.

  • Artemisinin
  • anticancer activity
  • Artesunate
  • dihydroartemisinin
  • review
  • Received August 31, 2017.
  • Revision received October 3, 2017.
  • Accepted October 5, 2017.
  • Copyright© 2017, International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved
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Anticancer Research: 37 (11)
Anticancer Research
Vol. 37, Issue 11
November 2017
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Anticancer Activity of Artemisinin and its Derivatives
SILVIA SLEZAKOVA, JANA RUDA-KUCEROVA
Anticancer Research Nov 2017, 37 (11) 5995-6003;

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Anticancer Activity of Artemisinin and its Derivatives
SILVIA SLEZAKOVA, JANA RUDA-KUCEROVA
Anticancer Research Nov 2017, 37 (11) 5995-6003;
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    • Source and Extraction of Artemisinin
    • Mechanisms of Action of Artemisinin and its Derivatives (ARTs)
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Keywords

  • Artemisinin
  • anticancer activity
  • Artesunate
  • Dihydroartemisinin
  • review
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