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Research ArticleClinical Studies

Platinum-based Doublet Chemotherapy for Advanced Gastric Cancer with Disseminated Intravascular Coagulation

KEIJI SUGIYAMA, YUKIYA NARITA, SHIGENORI KADOWAKI, TAKASHI URA, MASAHIRO TAJIKA and KEI MURO
Anticancer Research January 2017, 37 (1) 309-313;
KEIJI SUGIYAMA
1Department of Clinical Oncology, Aichi Cancer Center Hospital, Aichi, Japan
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YUKIYA NARITA
1Department of Clinical Oncology, Aichi Cancer Center Hospital, Aichi, Japan
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  • For correspondence: yukiya.narita@aichi-cc.jp
SHIGENORI KADOWAKI
1Department of Clinical Oncology, Aichi Cancer Center Hospital, Aichi, Japan
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TAKASHI URA
1Department of Clinical Oncology, Aichi Cancer Center Hospital, Aichi, Japan
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MASAHIRO TAJIKA
2Department of Endoscopy, Aichi Cancer Center Hospital, Aichi, Japan
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KEI MURO
1Department of Clinical Oncology, Aichi Cancer Center Hospital, Aichi, Japan
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Abstract

Background: Disseminated intravascular coagulation (DIC) is a rare complication of advanced gastric cancer (AGC). Despite reports of the efficacy of chemotherapy for AGC with DIC, little is known of platinum-based doublet therapy. Patients and Methods: We conducted a single-institute, retrospective chart review of 500 consecutive chemotherapy-naïve patients with advanced gastric adenocarcinoma (recurrent or metastatic) from November 2010 to November 2015. Results: Six patients were diagnosed with AGC with DIC (1.2%); five (1.0%; 3 men, 2 women) received platinum-based doublet chemotherapy. All patients exhibited improved DIC and thrombocytopenia and survived for >100 days (range=114-313) with no therapy-related mortality. Grade ≥3 adverse effects included neutropenia, anemia, hyponatremia, catheter-related infection and diarrhea (maximum: 2 patients each). Conclusion: Fluoropyrimidine plus platinum combination therapy was effective against DIC and yielded acceptable survival outcomes. Combination chemotherapy should be considered as a primary therapy for AGC with DIC.

  • Chemotherapy
  • cisplatin
  • disseminated intravascular coagulopathy
  • fluoropyrimidine
  • 5-fluorouracil
  • gastric cancer
  • oxaliplatin
  • S-1
  • Received August 26, 2016.
  • Revision received November 13, 2016.
  • Accepted November 21, 2016.
  • Copyright© 2017 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved
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Anticancer Research: 37 (1)
Anticancer Research
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January 2017
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Platinum-based Doublet Chemotherapy for Advanced Gastric Cancer with Disseminated Intravascular Coagulation
KEIJI SUGIYAMA, YUKIYA NARITA, SHIGENORI KADOWAKI, TAKASHI URA, MASAHIRO TAJIKA, KEI MURO
Anticancer Research Jan 2017, 37 (1) 309-313;

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Platinum-based Doublet Chemotherapy for Advanced Gastric Cancer with Disseminated Intravascular Coagulation
KEIJI SUGIYAMA, YUKIYA NARITA, SHIGENORI KADOWAKI, TAKASHI URA, MASAHIRO TAJIKA, KEI MURO
Anticancer Research Jan 2017, 37 (1) 309-313;
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Keywords

  • chemotherapy
  • cisplatin
  • disseminated intravascular coagulopathy
  • fluoropyrimidine
  • 5-fluorouracil
  • gastric cancer
  • oxaliplatin
  • S-1
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