Skip to main content

Main menu

  • Home
  • Current Issue
  • Archive
  • Info for
    • Authors
    • Subscribers
    • Advertisers
    • Editorial Board
  • Other Publications
    • In Vivo
    • Cancer Genomics & Proteomics
    • Cancer Diagnosis & Prognosis
  • More
    • IIAR
    • Conferences
    • 2008 Nobel Laureates
  • About Us
    • General Policy
    • Contact
  • Other Publications
    • Anticancer Research
    • In Vivo
    • Cancer Genomics & Proteomics

User menu

  • Register
  • Subscribe
  • My alerts
  • Log in
  • My Cart

Search

  • Advanced search
Anticancer Research
  • Other Publications
    • Anticancer Research
    • In Vivo
    • Cancer Genomics & Proteomics
  • Register
  • Subscribe
  • My alerts
  • Log in
  • My Cart
Anticancer Research

Advanced Search

  • Home
  • Current Issue
  • Archive
  • Info for
    • Authors
    • Subscribers
    • Advertisers
    • Editorial Board
  • Other Publications
    • In Vivo
    • Cancer Genomics & Proteomics
    • Cancer Diagnosis & Prognosis
  • More
    • IIAR
    • Conferences
    • 2008 Nobel Laureates
  • About Us
    • General Policy
    • Contact
  • Visit us on Facebook
  • Follow us on Linkedin
Research ArticleClinical Studies

Gender Difference in Distribution of Estrogen and Androgen Receptors in Intestinal-type Gastric Cancer

ZORAN JUKIC, PETRA RADULOVIC, RANKO STOJKOVIĆ, AUGUST MIJIC, JOSIP GRAH, BOZO KRUSLIN, ZELJKO FERENCIC and ALEKSANDRA FUCIC
Anticancer Research January 2017, 37 (1) 197-202;
ZORAN JUKIC
1General Hospital Nova Gradiska, Nova Gradiska, Croatia
5School of Medicine, J.J. Strossmayer University of Osijek, Osijek, Croatia
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
PETRA RADULOVIC
2Sestre Milosrdnice University Hospital Center, Zagreb, Croatia
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
RANKO STOJKOVIĆ
3Rudjer Boskovic Institute, Zagreb, Croatia
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
AUGUST MIJIC
2Sestre Milosrdnice University Hospital Center, Zagreb, Croatia
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
JOSIP GRAH
4Rebro, Clinical Hospital Centre, Zagreb, Croatia
5School of Medicine, J.J. Strossmayer University of Osijek, Osijek, Croatia
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
BOZO KRUSLIN
2Sestre Milosrdnice University Hospital Center, Zagreb, Croatia
6School of Medicine, University of Zagreb, Zagreb, Croatia
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
ZELJKO FERENCIC
7Srebrnjak Clinical Hospital, Zagreb, Croatia
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
ALEKSANDRA FUCIC
8Institute for Medical Research and Occupational Health, Zagreb, Croatia
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • For correspondence: afucic@imi.hr
  • Article
  • Figures & Data
  • Info & Metrics
  • PDF
Loading

Abstract

Background: Gender difference in survival of patients with gastric cancer is not well investigated. The aim of this study was to analyze the gender-related distribution of estrogen receptor alpha (ERα) and androgen receptor (AR) in the epithelium and stroma of intestinal-type gastric cancer. Materials and Methods: Immunohistochemical analysis was performed in 60 patients (42% females). Results: In gastric cancer patients, frequency of ERα-positive cells was lower in epithelium than in healthy individuals, but not significantly. In stroma and epithelium, AR-positive cells were absent from samples of women with T1 and T2 stage disease, while in men, their frequency was significantly increased in stroma of those with T3 and T4 stages and was significantly higher compared to women. AR-positive cells in stroma were fibroblasts, myofibroblasts and mast cells. Conclusion: To our knowledge, this study is the first to show gender differences in the distribution and frequency of AR-positive cells in neoplastic stroma of gastric cancer.

  • Intestinal gastric cancer
  • estrogen receptor
  • androgen receptor
  • stroma
  • mast cell
  • myofibroblast
  • Received November 10, 2016.
  • Revision received December 9, 2016.
  • Accepted December 16, 2016.
  • Copyright© 2017 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved
View Full Text
PreviousNext
Back to top

In this issue

Anticancer Research: 37 (1)
Anticancer Research
Vol. 37, Issue 1
January 2017
  • Table of Contents
  • Table of Contents (PDF)
  • Index by author
  • Back Matter (PDF)
  • Ed Board (PDF)
  • Front Matter (PDF)
Print
Download PDF
Article Alerts
Sign In to Email Alerts with your Email Address
Email Article

Thank you for your interest in spreading the word on Anticancer Research.

NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address.

Enter multiple addresses on separate lines or separate them with commas.
Gender Difference in Distribution of Estrogen and Androgen Receptors in Intestinal-type Gastric Cancer
(Your Name) has sent you a message from Anticancer Research
(Your Name) thought you would like to see the Anticancer Research web site.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
2 + 7 =
Solve this simple math problem and enter the result. E.g. for 1+3, enter 4.
Citation Tools
Gender Difference in Distribution of Estrogen and Androgen Receptors in Intestinal-type Gastric Cancer
ZORAN JUKIC, PETRA RADULOVIC, RANKO STOJKOVIĆ, AUGUST MIJIC, JOSIP GRAH, BOZO KRUSLIN, ZELJKO FERENCIC, ALEKSANDRA FUCIC
Anticancer Research Jan 2017, 37 (1) 197-202;

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
Reprints and Permissions
Share
Gender Difference in Distribution of Estrogen and Androgen Receptors in Intestinal-type Gastric Cancer
ZORAN JUKIC, PETRA RADULOVIC, RANKO STOJKOVIĆ, AUGUST MIJIC, JOSIP GRAH, BOZO KRUSLIN, ZELJKO FERENCIC, ALEKSANDRA FUCIC
Anticancer Research Jan 2017, 37 (1) 197-202;
del.icio.us logo Digg logo Reddit logo Twitter logo Facebook logo Google logo Mendeley logo
  • Tweet Widget
  • Facebook Like
  • Google Plus One

Jump to section

  • Article
    • Abstract
    • Materials and Methods
    • Results
    • Discussion
    • Acknowledgements
    • Footnotes
    • References
  • Figures & Data
  • Info & Metrics
  • PDF

Related Articles

  • No related articles found.
  • PubMed
  • Google Scholar

Cited By...

  • Androgen Receptor as a Biomarker of Oral Squamous Cell Carcinoma Progression Risk
  • Google Scholar

More in this TOC Section

  • The Systemic Inflammation Score Is an Independent Prognostic Factor for Esophageal Cancer Patients who Receive Curative Treatment
  • Impact of Cytoreductive Nephrectomy Following Nivolumab Plus Ipilimumab Therapy for Patients With Advanced Renal Cell Carcinoma
  • Usefulness of Prophylactic Administration of Pegfilgrastim for Esophageal Cancer Chemotherapy: A Single-center Retrospective Study
Show more Clinical Studies

Similar Articles

Keywords

  • Intestinal gastric cancer
  • estrogen receptor
  • androgen receptor
  • stroma
  • mast cell
  • myofibroblast
Anticancer Research

© 2022 Anticancer Research

Powered by HighWire