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Research ArticleClinical Studies

Efficacy and Toxicity of Panitumumab After Progression on Cetuximab and Predictive Value of MiR-31-5p in Metastatic Wild-type KRAS Colorectal Cancer Patients

IGOR KISS, JITKA MLCOCHOVA, ZBYNEK BORTLICEK, ALEXANDR POPRACH, JIRI DRABEK, PETRA VYCHYTILOVA-FALTEJSKOVA, MAREK SVOBODA, TOMAS BUCHLER, STANISLAV BATKO, ALES RYSKA, MARIAN HAJDUCH and ONDREJ SLABY
Anticancer Research September 2016, 36 (9) 4955-4959;
IGOR KISS
1Department of Comprehensive Cancer Care, Masaryk Memorial Cancer Institute, Brno, Czech Republic
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  • For correspondence: kiss{at}mou.cz on.slaby{at}gmail.com
JITKA MLCOCHOVA
2Central European Institute of Technology, Masaryk University, Brno, Czech Republic
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ZBYNEK BORTLICEK
3Institute of Biostatistics and Analyses, Faculty of Medicine, Masaryk University, Brno, Czech Republic
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ALEXANDR POPRACH
1Department of Comprehensive Cancer Care, Masaryk Memorial Cancer Institute, Brno, Czech Republic
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JIRI DRABEK
4Institute of Molecular and Translational Medicine, Faculty of Medicine and Dentistry, Palacky University Olomouc, Olomouc, Czech Republic
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PETRA VYCHYTILOVA-FALTEJSKOVA
1Department of Comprehensive Cancer Care, Masaryk Memorial Cancer Institute, Brno, Czech Republic
2Central European Institute of Technology, Masaryk University, Brno, Czech Republic
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MAREK SVOBODA
1Department of Comprehensive Cancer Care, Masaryk Memorial Cancer Institute, Brno, Czech Republic
2Central European Institute of Technology, Masaryk University, Brno, Czech Republic
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TOMAS BUCHLER
5Department of Oncology, Thomayer Hospital and Charles University First Faculty of Medicine, Prague, Czech Republic
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STANISLAV BATKO
6Department of Oncology, Motol University Hospital and Charles University Second Faculty of Medicine, Prague, Czech Republic
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ALES RYSKA
7The Fingerland Department of Pathology, Charles University Medical Faculty Hospital, Hradec Kralove, Czech Republic
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MARIAN HAJDUCH
4Institute of Molecular and Translational Medicine, Faculty of Medicine and Dentistry, Palacky University Olomouc, Olomouc, Czech Republic
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ONDREJ SLABY
1Department of Comprehensive Cancer Care, Masaryk Memorial Cancer Institute, Brno, Czech Republic
2Central European Institute of Technology, Masaryk University, Brno, Czech Republic
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  • For correspondence: kiss{at}mou.cz on.slaby{at}gmail.com
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    Figure 1.

    Treatment response (A) and progression-free survival (PFS) with panitumumab (B) in metastatic colorectal cancer patients after progression on cetuximab. PR, Partial response; CR, complete response; SD, stable disease; PD, progressive disease.

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    Figure 2.

    Relationship of cetuximab and consequent panitumumab therapeutic response and progression-free survival (PFS). Response to panitumumab in patients stratified according to their response to cetuximab (A). PFS with panitumumab treatment according to cetuximab treatment response (B). PFS with panitumumab according to median PFS on cetuximab treatment (C). PR, Partial response; CR, complete response; SD, stable disease; PD, progressive disease.

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    Figure 3.

    MiR-31-5p as predictive biomarker to anti-epidermal growth factor receptor (EGFR) therapy. Progression-free survival (PFS) from cetuximab treatment initiation according to miR-31-5p expression levels (A). PFS from panitumumab treatment initiation according to miR-31-5p expression level (B).

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Anticancer Research
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September 2016
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Efficacy and Toxicity of Panitumumab After Progression on Cetuximab and Predictive Value of MiR-31-5p in Metastatic Wild-type KRAS Colorectal Cancer Patients
IGOR KISS, JITKA MLCOCHOVA, ZBYNEK BORTLICEK, ALEXANDR POPRACH, JIRI DRABEK, PETRA VYCHYTILOVA-FALTEJSKOVA, MAREK SVOBODA, TOMAS BUCHLER, STANISLAV BATKO, ALES RYSKA, MARIAN HAJDUCH, ONDREJ SLABY
Anticancer Research Sep 2016, 36 (9) 4955-4959;

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Efficacy and Toxicity of Panitumumab After Progression on Cetuximab and Predictive Value of MiR-31-5p in Metastatic Wild-type KRAS Colorectal Cancer Patients
IGOR KISS, JITKA MLCOCHOVA, ZBYNEK BORTLICEK, ALEXANDR POPRACH, JIRI DRABEK, PETRA VYCHYTILOVA-FALTEJSKOVA, MAREK SVOBODA, TOMAS BUCHLER, STANISLAV BATKO, ALES RYSKA, MARIAN HAJDUCH, ONDREJ SLABY
Anticancer Research Sep 2016, 36 (9) 4955-4959;
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Keywords

  • metastatic colorectal cancer
  • cetuximab
  • panitumumab
  • KRAS
  • microRNA
  • miR-31-5p
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