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Research ArticleClinical Studies

Does the Rectus Sheath Block Analgesia Reduce the Inflammatory Response Biomarkers' IL-1ra, IL-6, IL-8, IL-10 and IL-1β Concentrations Following Surgery? A Randomized Clinical Trial of Patients with Cancer and Benign Disease

MARTIN PURDY, MERJA KOKKI, MAARIT ANTTILA, SAMULI ASPINEN, PETRI JUVONEN, RIIKA KORHONEN, TUOMAS SELANDER, HANNU KOKKI and MATTI ESKELINEN
Anticancer Research June 2016, 36 (6) 3005-3011;
MARTIN PURDY
1Department of Surgery, Kuopio University Hospital and School of Medicine, University of Eastern Finland, Kuopio, Finland
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MERJA KOKKI
2Department of Anaesthesia and Operative Services, Kuopio University Hospital and School of Medicine, University of Eastern Finland, Kuopio, Finland
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MAARIT ANTTILA
3Department of Gynaecology, Kuopio University Hospital, Kuopio, Finland
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SAMULI ASPINEN
1Department of Surgery, Kuopio University Hospital and School of Medicine, University of Eastern Finland, Kuopio, Finland
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PETRI JUVONEN
1Department of Surgery, Kuopio University Hospital and School of Medicine, University of Eastern Finland, Kuopio, Finland
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RIIKA KORHONEN
1Department of Surgery, Kuopio University Hospital and School of Medicine, University of Eastern Finland, Kuopio, Finland
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TUOMAS SELANDER
4Science Service Centre, Kuopio University Hospital, Kuopio, Finland
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HANNU KOKKI
2Department of Anaesthesia and Operative Services, Kuopio University Hospital and School of Medicine, University of Eastern Finland, Kuopio, Finland
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MATTI ESKELINEN
1Department of Surgery, Kuopio University Hospital and School of Medicine, University of Eastern Finland, Kuopio, Finland
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  • For correspondence: matti.eskelinen@kuh.fi
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    Figure 1.

    Flowchart of study's design.

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    Figure 2.

    Jitter plots of the individual NRS values versus IL-10 values for the placebo group and three study groups (r=0.4, p=0.03).

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    Figure 3.

    Jitter plots of the individual NRS values versus IL-1β values for the placebo group and three study groups (r=0.38, p=0.04).

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Anticancer Research: 36 (6)
Anticancer Research
Vol. 36, Issue 6
June 2016
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Does the Rectus Sheath Block Analgesia Reduce the Inflammatory Response Biomarkers' IL-1ra, IL-6, IL-8, IL-10 and IL-1β Concentrations Following Surgery? A Randomized Clinical Trial of Patients with Cancer and Benign Disease
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Does the Rectus Sheath Block Analgesia Reduce the Inflammatory Response Biomarkers' IL-1ra, IL-6, IL-8, IL-10 and IL-1β Concentrations Following Surgery? A Randomized Clinical Trial of Patients with Cancer and Benign Disease
MARTIN PURDY, MERJA KOKKI, MAARIT ANTTILA, SAMULI ASPINEN, PETRI JUVONEN, RIIKA KORHONEN, TUOMAS SELANDER, HANNU KOKKI, MATTI ESKELINEN
Anticancer Research Jun 2016, 36 (6) 3005-3011;

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Does the Rectus Sheath Block Analgesia Reduce the Inflammatory Response Biomarkers' IL-1ra, IL-6, IL-8, IL-10 and IL-1β Concentrations Following Surgery? A Randomized Clinical Trial of Patients with Cancer and Benign Disease
MARTIN PURDY, MERJA KOKKI, MAARIT ANTTILA, SAMULI ASPINEN, PETRI JUVONEN, RIIKA KORHONEN, TUOMAS SELANDER, HANNU KOKKI, MATTI ESKELINEN
Anticancer Research Jun 2016, 36 (6) 3005-3011;
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Keywords

  • cancer
  • IL-1ra
  • IL-6
  • IL-8
  • IL-10
  • IL-1β
  • analgesia
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