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Research ArticleClinical Studies

Combining the Glasgow Prognostic Score and Serum Carbohydrate Antigen 19-9 Level Improves the Ability to Predict Early Recurrence in Resected Pancreatic Cancer Patients Receiving Adjuvant Gemcitabine

KOJI NUMATA, SOICHIRO MORINAGA, YUSUKE KATAYAMA, SHO SAWAZAKI, MASAKATSU NUMATA, TENI GODAI, AKIO HIGUCHI, MANABU SHIOZAWA, YASUSHI RINO, MUNETAKA MASUDA and MAKOTO AKAIKE
Anticancer Research May 2016, 36 (5) 2467-2474;
KOJI NUMATA
1Department of Gastrointestinal Surgery, Kanagawa Cancer Center, Asahiku, Yokohama, Japan
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  • For correspondence: koji-numata@hotmail.co.jp
SOICHIRO MORINAGA
1Department of Gastrointestinal Surgery, Kanagawa Cancer Center, Asahiku, Yokohama, Japan
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YUSUKE KATAYAMA
2Department of Surgery, Yokohama City University, Kanazawaku, Yokohama, Japan
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SHO SAWAZAKI
2Department of Surgery, Yokohama City University, Kanazawaku, Yokohama, Japan
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MASAKATSU NUMATA
2Department of Surgery, Yokohama City University, Kanazawaku, Yokohama, Japan
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TENI GODAI
3Department of Surgery, Fujisawa Shonandai Hospital, Fujisawa, Japan
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AKIO HIGUCHI
1Department of Gastrointestinal Surgery, Kanagawa Cancer Center, Asahiku, Yokohama, Japan
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MANABU SHIOZAWA
1Department of Gastrointestinal Surgery, Kanagawa Cancer Center, Asahiku, Yokohama, Japan
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YASUSHI RINO
2Department of Surgery, Yokohama City University, Kanazawaku, Yokohama, Japan
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MUNETAKA MASUDA
2Department of Surgery, Yokohama City University, Kanazawaku, Yokohama, Japan
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MAKOTO AKAIKE
4Department of General Medicine, Chigasaki Chuo Hospital, Chigasaki, Japan
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    Figure 1.

    (a) Disease-free survival curves based on the Glasgow Prognostic Score (GPS). The 1-year disease-free survival rates of the patients with a GPS of 0 (solid line) or 1 or 2 (dotted line) were 36.8% and 14.4%, respectively. (b) Overall survival curves based on the Glasgow Prognostic Score (GPS). The 1-year overall survival rates of the patients with a GPS of 0 (solid line) or 1 or 2 (dotted line) were 89.2% and 58.0%, respectively. (c) Disease-free survival curves based on the CA19-9 level. The 1-year disease-free survival rates of the patients with a CA19-9 level below 180 U/ml (solid line) or 180 U/ml or above (dotted line) were 36.4% and 5.9% (not reached), respectively. (d) Overall survival curves based on the CA19-9 level. The 1-year overall survival rates of the patients with a CA19-9 level below 180 U/ml (solid line) or 180 U/ml or above (dotted line) were 89.1% and 40.3%, respectively.

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    Figure 2.

    The overall survival (OS) of the patients was significantly shorter when stratified by GPS and CA19-9 status (by log-rank test).

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Anticancer Research: 36 (5)
Anticancer Research
Vol. 36, Issue 5
May 2016
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Combining the Glasgow Prognostic Score and Serum Carbohydrate Antigen 19-9 Level Improves the Ability to Predict Early Recurrence in Resected Pancreatic Cancer Patients Receiving Adjuvant Gemcitabine
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Combining the Glasgow Prognostic Score and Serum Carbohydrate Antigen 19-9 Level Improves the Ability to Predict Early Recurrence in Resected Pancreatic Cancer Patients Receiving Adjuvant Gemcitabine
KOJI NUMATA, SOICHIRO MORINAGA, YUSUKE KATAYAMA, SHO SAWAZAKI, MASAKATSU NUMATA, TENI GODAI, AKIO HIGUCHI, MANABU SHIOZAWA, YASUSHI RINO, MUNETAKA MASUDA, MAKOTO AKAIKE
Anticancer Research May 2016, 36 (5) 2467-2474;

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Combining the Glasgow Prognostic Score and Serum Carbohydrate Antigen 19-9 Level Improves the Ability to Predict Early Recurrence in Resected Pancreatic Cancer Patients Receiving Adjuvant Gemcitabine
KOJI NUMATA, SOICHIRO MORINAGA, YUSUKE KATAYAMA, SHO SAWAZAKI, MASAKATSU NUMATA, TENI GODAI, AKIO HIGUCHI, MANABU SHIOZAWA, YASUSHI RINO, MUNETAKA MASUDA, MAKOTO AKAIKE
Anticancer Research May 2016, 36 (5) 2467-2474;
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Keywords

  • Glasgow prognostic score
  • carbohydrate antigen 19-9
  • pancreatic cancer
  • early recurrence
  • gemcitabine monotherapy
  • curative surgery
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