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Review ArticleReviewR

Anticancer Properties of Capsaicin Against Human Cancer

RUTH CLARK and SEONG-HO LEE
Anticancer Research March 2016, 36 (3) 837-843;
RUTH CLARK
Department of Nutrition and Food Science, College of Agriculture and Natural Resources, University of Maryland, College Park, MD, U.S.A.
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SEONG-HO LEE
Department of Nutrition and Food Science, College of Agriculture and Natural Resources, University of Maryland, College Park, MD, U.S.A.
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  • For correspondence: slee2000@umd.edu
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Abstract

There is persuasive epidemiological and experimental evidence that dietary phytochemicals have anticancer activity. Capsaicin is a bioactive phytochemical abundant in red and chili peppers. While the preponderance of the data strongly indicates significant anticancer benefits of capsaicin, more information to highlight molecular mechanisms of its action is required to improve our knowledge to be able to propose a potential therapeutic strategy for use of capsaicin against cancer. Capsaicin has been shown to alter the expression of several genes involved in cancer cell survival, growth arrest, angiogenesis and metastasis. Recently, many research groups, including ours, found that capsaicin targets multiple signaling pathways, oncogenes and tumor-suppressor genes in various types of cancer models. In this review article, we highlight multiple molecular targets responsible for the anticancer mechanism of capsaicin. In addition, we deal with the benefits of combinational use of capsaicin with other dietary or chemotherapeutic compounds, focusing on synergistic anticancer activities.

  • Capsaicin
  • apoptosis
  • cell cycle
  • angiogenesis
  • metastasis
  • review
  • Received January 6, 2016.
  • Revision received February 15, 2016.
  • Accepted February 16, 2016.
  • Copyright© 2016 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved
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Anticancer Research: 36 (3)
Anticancer Research
Vol. 36, Issue 3
March 2016
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Anticancer Properties of Capsaicin Against Human Cancer
RUTH CLARK, SEONG-HO LEE
Anticancer Research Mar 2016, 36 (3) 837-843;

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RUTH CLARK, SEONG-HO LEE
Anticancer Research Mar 2016, 36 (3) 837-843;
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  • Article
    • Abstract
    • Capsaicin and Apoptosis
    • Capsaicin and the Cell Cycle
    • Capsaicin and Angiogenesis
    • Capsaicin and Metastasis
    • Synergistic Anticancer Activity of Capsaicin with Other Compounds
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Keywords

  • Capsaicin
  • apoptosis
  • cell cycle
  • angiogenesis
  • metastasis
  • review
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