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Research ArticleClinical Studies

The Prognostic Role of KRAS Mutation in Patients with Advanced NSCLC Treated with Second- or Third-line Chemotherapy

MARTIN SVATON, ONDREJ FIALA, MILOS PESEK, ZBYNEK BORTLICEK, MAREK MINARIK, LUCIE BENESOVA and ONDREJ TOPOLCAN
Anticancer Research March 2016, 36 (3) 1077-1082;
MARTIN SVATON
1Department of Pneumology, University Hospital Pilsen, Charles University in Prague, Prague, Czech Republic
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  • For correspondence: svatonm@gmail.com
ONDREJ FIALA
2Department of Oncology and Radiotherapy, University Hospital Pilsen, Charles University in Prague, Prague, Czech Republic
3Biomedical Center, Faculty of Medicine in Pilsen, Charles University in Prague, Prague, Czech Republic
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MILOS PESEK
1Department of Pneumology, University Hospital Pilsen, Charles University in Prague, Prague, Czech Republic
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ZBYNEK BORTLICEK
4Institute of Biostatistics and Analyses, Masaryk University, Brno, Czech Republic
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MAREK MINARIK
5Centre for Applied Genomics of Solid Tumours, Genomac Research Institute, Prague, Czech Republic
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LUCIE BENESOVA
5Centre for Applied Genomics of Solid Tumours, Genomac Research Institute, Prague, Czech Republic
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ONDREJ TOPOLCAN
6Department of Nuclear Medicine, Faculty of Medicine in Pilsen, Charles University in Prague, Prague, Czech Republic
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    Figure 1.

    Progression-free (A) and overall (B) survival from treatment initiation according to Kirsten rat sarcoma viral oncogene homolog (KRAS) mutation status of patients treated with pemetrexed/docetaxel in second or third line.

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    Figure 2.

    Progression-free (A) and overall (B) survival from treatment initiation according to Kirsten rat sarcoma viral oncogene homolog (KRAS) mutation of patients treated with pemetrexed/docetaxel in second or third line.

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Anticancer Research: 36 (3)
Anticancer Research
Vol. 36, Issue 3
March 2016
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The Prognostic Role of KRAS Mutation in Patients with Advanced NSCLC Treated with Second- or Third-line Chemotherapy
MARTIN SVATON, ONDREJ FIALA, MILOS PESEK, ZBYNEK BORTLICEK, MAREK MINARIK, LUCIE BENESOVA, ONDREJ TOPOLCAN
Anticancer Research Mar 2016, 36 (3) 1077-1082;

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The Prognostic Role of KRAS Mutation in Patients with Advanced NSCLC Treated with Second- or Third-line Chemotherapy
MARTIN SVATON, ONDREJ FIALA, MILOS PESEK, ZBYNEK BORTLICEK, MAREK MINARIK, LUCIE BENESOVA, ONDREJ TOPOLCAN
Anticancer Research Mar 2016, 36 (3) 1077-1082;
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Keywords

  • KRAS
  • NSCLC
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  • prognosis
  • predictive marker
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