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Research ArticleClinical Studies

Bone-targeted Novel Cytotoxic Polybisphosphonate Conjugate in Castration-resistant Prostate Cancer: A Multicenter Phase 1 Study

CAMILLA THELLENBERG-KARLSSON, CLAES NYMAN, STEN NILSSON, RENÉ BLOM, MARCELA MÁRQUEZ, ENRIQUE CASTELLANOS and ANDERS R. HOLMBERG
Anticancer Research December 2016, 36 (12) 6499-6504;
CAMILLA THELLENBERG-KARLSSON
3Norrlands University Hospital, Umeå, Sweden
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CLAES NYMAN
2Stockholm South General Hospital, Stockholm, Sweden
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STEN NILSSON
1Karolinska Institute, CCK/R8/00, Stockholm, Sweden
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RENÉ BLOM
4Skånes University Hospital, Lund, Sweden
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MARCELA MÁRQUEZ
1Karolinska Institute, CCK/R8/00, Stockholm, Sweden
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ENRIQUE CASTELLANOS
1Karolinska Institute, CCK/R8/00, Stockholm, Sweden
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ANDERS R. HOLMBERG
1Karolinska Institute, CCK/R8/00, Stockholm, Sweden
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  • For correspondence: arh@telia.com
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Article Information

vol. 36 no. 12 6499-6504
PubMed 
27919973

Published By 
International Institute of Anticancer Research
Print ISSN 
0250-7005
Online ISSN 
1791-7530
History 
  • Received October 25, 2016
  • Revision received November 9, 2016
  • Accepted November 14, 2016
  • Published online December 5, 2016.

Copyright & Usage 
Copyright© 2016 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved

Author Information

  1. CAMILLA THELLENBERG-KARLSSON3,
  2. CLAES NYMAN2,
  3. STEN NILSSON1,
  4. RENÉ BLOM4,
  5. MARCELA MÁRQUEZ1,
  6. ENRIQUE CASTELLANOS1 and
  7. ANDERS R. HOLMBERG1⇑
  1. 1Karolinska Institute, CCK/R8/00, Stockholm, Sweden
  2. 2Stockholm South General Hospital, Stockholm, Sweden
  3. 3Norrlands University Hospital, Umeå, Sweden
  4. 4Skånes University Hospital, Lund, Sweden
  1. Correspondence to: Dr. Anders R. Holmberg, Karolinska Institute, CCK/R8/00, S-17176 Stockholm, Sweden. Tel: +46 733242782, e-mail: arh{at}telia.com
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Anticancer Research: 36 (12)
Anticancer Research
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December 2016
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Bone-targeted Novel Cytotoxic Polybisphosphonate Conjugate in Castration-resistant Prostate Cancer: A Multicenter Phase 1 Study
CAMILLA THELLENBERG-KARLSSON, CLAES NYMAN, STEN NILSSON, RENÉ BLOM, MARCELA MÁRQUEZ, ENRIQUE CASTELLANOS, ANDERS R. HOLMBERG
Anticancer Research Dec 2016, 36 (12) 6499-6504;

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Bone-targeted Novel Cytotoxic Polybisphosphonate Conjugate in Castration-resistant Prostate Cancer: A Multicenter Phase 1 Study
CAMILLA THELLENBERG-KARLSSON, CLAES NYMAN, STEN NILSSON, RENÉ BLOM, MARCELA MÁRQUEZ, ENRIQUE CASTELLANOS, ANDERS R. HOLMBERG
Anticancer Research Dec 2016, 36 (12) 6499-6504;
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Keywords

  • Polybisphosphonate
  • cytotoxic
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  • metastasis
  • bone-targeting
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