Research ArticleExperimental Studies

Expression Levels of PIWI-interacting RNA, piR-823, Are Deregulated in Tumor Tissue, Blood Serum and Urine of Patients with Renal Cell Carcinoma

ROBERT ILIEV, MICHAL FEDORKO, TANA MACHACKOVA, HANA MLCOCHOVA, MAREK SVOBODA, DALIBOR PACIK, JAN DOLEZEL, MICHAL STANIK and ONDREJ SLABY
Anticancer Research December 2016, 36 (12) 6419-6423;

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Figures

  • Figure 1.
    Figure 1.

    Statistical significant difference in piR-823 expression (p<0.0001) between 121 paired samples of renal cell carcinoma tumor tissue (TU) and paired healthy renal parenchyma (RP).

  • Figure 2.
    Figure 2.

    piR-823 levels and disease-free survival of patients with renal cell carcinoma. There was a proven statistically significant (p=0.0186) association of longer disease-free survival in patients with low expression of piR-823 in tumor tissue compared to those with high expression.

  • Figure 3.
    Figure 3.

    piR-823 levels measured in blood serum (A) and urine (B). In patients with renal cell carcinoma (RCC), the piR-823 levels were increased compared to those in healthy individuals. Levels of piR-823 in urine of patients with RCC were higher in comparison with those in urine of healthy individuals. Lines represent medians, and bars are 25th and 75th percentiles.

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Expression Levels of PIWI-interacting RNA, piR-823, Are Deregulated in Tumor Tissue, Blood Serum and Urine of Patients with Renal Cell Carcinoma
ROBERT ILIEV, MICHAL FEDORKO, TANA MACHACKOVA, HANA MLCOCHOVA, MAREK SVOBODA, DALIBOR PACIK, JAN DOLEZEL, MICHAL STANIK, ONDREJ SLABY
Anticancer Research Dec 2016, 36 (12) 6419-6423;
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