Skip to main content

Main menu

  • Home
  • Current Issue
  • Archive
  • Info for
    • Authors
    • Editorial Policies
    • Subscribers
    • Advertisers
    • Editorial Board
    • Special Issues 2025
  • Journal Metrics
  • Other Publications
    • In Vivo
    • Cancer Genomics & Proteomics
    • Cancer Diagnosis & Prognosis
  • More
    • IIAR
    • Conferences
    • 2008 Nobel Laureates
  • About Us
    • General Policy
    • Contact
  • Other Publications
    • Anticancer Research
    • In Vivo
    • Cancer Genomics & Proteomics

User menu

  • Register
  • Subscribe
  • My alerts
  • Log in
  • My Cart

Search

  • Advanced search
Anticancer Research
  • Other Publications
    • Anticancer Research
    • In Vivo
    • Cancer Genomics & Proteomics
  • Register
  • Subscribe
  • My alerts
  • Log in
  • My Cart
Anticancer Research

Advanced Search

  • Home
  • Current Issue
  • Archive
  • Info for
    • Authors
    • Editorial Policies
    • Subscribers
    • Advertisers
    • Editorial Board
    • Special Issues 2025
  • Journal Metrics
  • Other Publications
    • In Vivo
    • Cancer Genomics & Proteomics
    • Cancer Diagnosis & Prognosis
  • More
    • IIAR
    • Conferences
    • 2008 Nobel Laureates
  • About Us
    • General Policy
    • Contact
  • Visit us on Facebook
  • Follow us on Linkedin
Research ArticleClinical Studies

Value of the Nottingham Histological Grading Parameters and Nottingham Prognostic Index in Canine Mammary Carcinoma

MARTA SANTOS, CARLA CORREIA-GOMES, RICARDO MARCOS, ANDREIA SANTOS, AUGUSTO DE MATOS, CARLOS LOPES and PATRÍCIA DIAS-PEREIRA
Anticancer Research July 2015, 35 (7) 4219-4227;
MARTA SANTOS
1Department of Microscopy, Institute of Biomedical Sciences Abel Salazar, ICBAS-UPorto, University of Porto, Porto, Portugal
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
CARLA CORREIA-GOMES
2Epidemiology Research Unit, Future Farming Systems, Scotland's Rural College, Inverness, U.K.
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
RICARDO MARCOS
1Department of Microscopy, Institute of Biomedical Sciences Abel Salazar, ICBAS-UPorto, University of Porto, Porto, Portugal
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
ANDREIA SANTOS
3Faculty of Veterinary Medicine, Lusófona University of Humanities and Technologies, Lisbon, Portugal
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
AUGUSTO DE MATOS
4Department of Veterinary Clinics, Institute of Biomedical Sciences Abel Salazar, ICBAS-UPorto, University of Porto, Porto, Portugal
5Animal Science and Study Central, Food and Agrarian Sciences and Technologies Institute, University of Porto, Porto, Portugal
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
CARLOS LOPES
6Department of Pathology and Molecular Immunology, Institute of Biomedical Sciences Abel Salazar, ICBAS-UPorto, University of Porto, Porto, Portugal
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
PATRÍCIA DIAS-PEREIRA
6Department of Pathology and Molecular Immunology, Institute of Biomedical Sciences Abel Salazar, ICBAS-UPorto, University of Porto, Porto, Portugal
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • For correspondence: pdiaspereira@yahoo.com.br
  • Article
  • Figures & Data
  • Info & Metrics
  • PDF
Loading

Article Figures & Data

Figures

  • Tables
  • Figure 1.
    • Download figure
    • Open in new tab
    • Download powerpoint
    Figure 1.

    Nottingham histological grade: criteria for scoring each grading parameter [adapted from Elston and Ellis (9)]. *Cells similar to normal surrounding parenchyma; **counted in 10 high-power fields, field diameter of 0.55 mm.

  • Figure 2.
    • Download figure
    • Open in new tab
    • Download powerpoint
    Figure 2.

    Kaplan–Meier curves of disease-free interval (DFI) and overall survival (OS) of cases included in each WHO tumor-size category. Female dogs with largest tumor diameter <3 cm had better survival outcomes but no statistical difference seemed to exist between the other two categories regarding DFI (log-rank test, p=0.03 for DFI; p=0.04 for OS). Censoring is indicated by vertical marks.

  • Figure 3.
    • Download figure
    • Open in new tab
    • Download powerpoint
    Figure 3.

    Kaplan–Meier plots comparing the disease-free interval (DFI) and overall survival (OS) of 59 female dogs according to largest tumor diameter. Cases with ≥2.9 cm were associated with poor survival (log-rank test, p=0.009 for DFI and p=0.02 for OS). Censoring is indicated by vertical marks.

  • Figure 4.
    • Download figure
    • Open in new tab
    • Download powerpoint
    Figure 4.

    Disease-free interval (DFI) and overall survival (OS) of 59 female dogs with grade I, grade II and grade III mammary malignant tumors. Significant differences existed between the three curves (log-rank test, p=0.002 for DFI and p=0.02 for OS). Censoring is indicated by vertical marks.

  • Figure 5.
    • Download figure
    • Open in new tab
    • Download powerpoint
    Figure 5.

    Kaplan–Meier analyses of disease-free interval (DFI) and overall survival (OS) among 59 female dogs with malignant mammary tumors. Animals with tumors graded I or II had a significantly longer DFI and OS when compared to animals with tumors graded III, according to the Nottingham histological grading method (log-rank test, p<0.0001 for DFI and p=0.008 for OS). Censoring is indicated by vertical marks.

  • Figure 6.
    • Download figure
    • Open in new tab
    • Download powerpoint
    Figure 6.

    Disease-free interval (DFI) and overall survival (OS) curves of female dogs with tumors scored 1 or 2 in nuclear pleomorphism compared to female dogs with tumors scored 3 in this parameter. Nuclear pleomorphism was significantly associated with survival (log-rank test, p<0.0001 for DFI and OS). Censoring is indicated by vertical marks.

  • Figure 7.
    • Download figure
    • Open in new tab
    • Download powerpoint
    Figure 7.

    A: Receiver operating characteristic curve for tumor progression in 59 female dogs based on the veterinary-adapted Nottingham Prognostic Index (NPI). The NPI had good discriminative power between tumors that progressed within the first 12 months post-surgery and those that did not progress. B: Kaplan–Meier plots of disease-free interval (DFI) and overall survival (OS) among 59 female dogs with malignant mammary tumors grouped by the NPI cut-off. NPI ≥4.25 was associated with poor survival outcomes (log-rank test, p<0.0001 for DFI and p=0.001 for OS curves). Censoring is indicated by vertical marks.

Tables

  • Figures
  • Table I.
  • Table II.
PreviousNext
Back to top

In this issue

Anticancer Research: 35 (7)
Anticancer Research
Vol. 35, Issue 7
July 2015
  • Table of Contents
  • Table of Contents (PDF)
  • Index by author
  • Back Matter (PDF)
  • Ed Board (PDF)
  • Front Matter (PDF)
Print
Download PDF
Article Alerts
Sign In to Email Alerts with your Email Address
Email Article

Thank you for your interest in spreading the word on Anticancer Research.

NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address.

Enter multiple addresses on separate lines or separate them with commas.
Value of the Nottingham Histological Grading Parameters and Nottingham Prognostic Index in Canine Mammary Carcinoma
(Your Name) has sent you a message from Anticancer Research
(Your Name) thought you would like to see the Anticancer Research web site.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
6 + 0 =
Solve this simple math problem and enter the result. E.g. for 1+3, enter 4.
Citation Tools
Value of the Nottingham Histological Grading Parameters and Nottingham Prognostic Index in Canine Mammary Carcinoma
MARTA SANTOS, CARLA CORREIA-GOMES, RICARDO MARCOS, ANDREIA SANTOS, AUGUSTO DE MATOS, CARLOS LOPES, PATRÍCIA DIAS-PEREIRA
Anticancer Research Jul 2015, 35 (7) 4219-4227;

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
Reprints and Permissions
Share
Value of the Nottingham Histological Grading Parameters and Nottingham Prognostic Index in Canine Mammary Carcinoma
MARTA SANTOS, CARLA CORREIA-GOMES, RICARDO MARCOS, ANDREIA SANTOS, AUGUSTO DE MATOS, CARLOS LOPES, PATRÍCIA DIAS-PEREIRA
Anticancer Research Jul 2015, 35 (7) 4219-4227;
Twitter logo Facebook logo Mendeley logo
  • Tweet Widget
  • Facebook Like
  • Google Plus One

Jump to section

  • Article
    • Abstract
    • Materials and Methods
    • Results
    • Discussion
    • Footnotes
    • References
  • Figures & Data
  • Info & Metrics
  • PDF

Related Articles

  • No related articles found.
  • PubMed
  • Google Scholar

Cited By...

  • No citing articles found.
  • Google Scholar

More in this TOC Section

  • Correlation Between Body Mass Index and Clinical Outcomes in Advanced Renal Cell Carcinoma Patients
  • Combined Biomarkers for Prediction of Immune Checkpoint Inhibitor Response in Patients With Triple-negative Breast Cancer
  • A Case of Complete Response to ICI Therapy for Unresectable Esophageal Squamous Cell Carcinoma
Show more Clinical Studies

Similar Articles

Keywords

  • Canine mammary tumors
  • Nottingham histological grade
  • prognosis
  • survival
Anticancer Research

© 2025 Anticancer Research

Powered by HighWire