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Research ArticleClinical studies

Bevacizumab and Postoperative Wound Complications in Patients with Liver Metastases of Colorectal Cancer

HIROFUMI UTSUMI, YOSHITAKA HONMA, KENGO NAGASHIMA, SATORU IWASA, ATSUO TAKASHIMA, KEN KATO, TETSUYA HAMAGUCHI, YASUHIDE YAMADA, YASUHIRO SHIMADA, YOJI KISHI, SATOSHI NARA, MINORU ESAKI and KAZUAKI SHIMADA
Anticancer Research April 2015, 35 (4) 2255-2261;
HIROFUMI UTSUMI
1Gastrointestinal Medical Oncology Division, National Cancer Center Hospital, Tokyo, Japan
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YOSHITAKA HONMA
1Gastrointestinal Medical Oncology Division, National Cancer Center Hospital, Tokyo, Japan
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  • For correspondence: yohonma@ncc.go.jp
KENGO NAGASHIMA
2Clinical Research Center, Chiba University Hospital, Chiba, Japan
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SATORU IWASA
1Gastrointestinal Medical Oncology Division, National Cancer Center Hospital, Tokyo, Japan
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ATSUO TAKASHIMA
1Gastrointestinal Medical Oncology Division, National Cancer Center Hospital, Tokyo, Japan
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KEN KATO
1Gastrointestinal Medical Oncology Division, National Cancer Center Hospital, Tokyo, Japan
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TETSUYA HAMAGUCHI
1Gastrointestinal Medical Oncology Division, National Cancer Center Hospital, Tokyo, Japan
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YASUHIDE YAMADA
1Gastrointestinal Medical Oncology Division, National Cancer Center Hospital, Tokyo, Japan
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YASUHIRO SHIMADA
1Gastrointestinal Medical Oncology Division, National Cancer Center Hospital, Tokyo, Japan
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YOJI KISHI
3Hepato-Biliary-Pancreatic Surgery Division, National Cancer Center Hospital, Tokyo, Japan
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SATOSHI NARA
3Hepato-Biliary-Pancreatic Surgery Division, National Cancer Center Hospital, Tokyo, Japan
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MINORU ESAKI
3Hepato-Biliary-Pancreatic Surgery Division, National Cancer Center Hospital, Tokyo, Japan
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KAZUAKI SHIMADA
3Hepato-Biliary-Pancreatic Surgery Division, National Cancer Center Hospital, Tokyo, Japan
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Abstract

Aim: The present study investigated whether bevacizumab (BV) is associated with postoperative wound complications (PWCs). Patients and Methods: We retrospectively analyzed patients undergoing surgery for liver metastases of colorectal cancer at our Institution. Patients were divided into 3 groups according to the preoperative treatment: che mo therapy with BV (group A), chemotherapy without BV (group B) and no chemotherapy (group C). Results: Between February 2003 and September 2012, 297 patients underwent 373 surgeries. Groups A, B and C consisted of 23, 62 and 288 patients, respectively. PWCs occurred in 29 patients (7.8%). In multivariate analysis, there were no differences in PWCs among the groups (C vs. B:P=0.739; C vs. A: P=0.110). Conversely, lower serum albumin levels (<3.5g/dl vs. ≥3.5g/dl: p=0.030) and synchronous colorectal resection (no vs. yes; p<0.001) remained significant risk factors of developing PWCs. Conclusion: Chemotherapy with or without BV did not influence the risk of PWCs.

  • Bevacizumab
  • postoperative wound complications
  • liver metastases of colorectal cancer
  • Received January 12, 2015.
  • Revision received January 24, 2015.
  • Accepted January 27, 2015.
  • Copyright© 2015 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved
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Anticancer Research: 35 (4)
Anticancer Research
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April 2015
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Bevacizumab and Postoperative Wound Complications in Patients with Liver Metastases of Colorectal Cancer
HIROFUMI UTSUMI, YOSHITAKA HONMA, KENGO NAGASHIMA, SATORU IWASA, ATSUO TAKASHIMA, KEN KATO, TETSUYA HAMAGUCHI, YASUHIDE YAMADA, YASUHIRO SHIMADA, YOJI KISHI, SATOSHI NARA, MINORU ESAKI, KAZUAKI SHIMADA
Anticancer Research Apr 2015, 35 (4) 2255-2261;

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Bevacizumab and Postoperative Wound Complications in Patients with Liver Metastases of Colorectal Cancer
HIROFUMI UTSUMI, YOSHITAKA HONMA, KENGO NAGASHIMA, SATORU IWASA, ATSUO TAKASHIMA, KEN KATO, TETSUYA HAMAGUCHI, YASUHIDE YAMADA, YASUHIRO SHIMADA, YOJI KISHI, SATOSHI NARA, MINORU ESAKI, KAZUAKI SHIMADA
Anticancer Research Apr 2015, 35 (4) 2255-2261;
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Keywords

  • bevacizumab
  • postoperative wound complications
  • liver metastases of colorectal cancer
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