Article Figures & Data
Figures
- Figure 1.
Chemical structures of new derivatives of doxorubicin tested in the study.
- Figure 2.
The fraction of early apoptotic, late apoptotic and necrotic cells after 4, 48 and 72 h exposure to doxorubicin (DOX) and compounds 1-5 obtained after double staining with Hoechst 33258 and propidium iodide. Statistically significant difference in comparison to *control cells, #to the probes with doxorubicin at p<0.05. The values are the mean±SD of five independent experiments.
- Figure 3.
Representative cytograms after double staining with Annexin V Fluorescein isothiocyanate and propidium iodide (PI) of MCF-7 cell line after incubation with doxorubicin (DOX) and compounds 1-5 for 72 h.
- Figure 4.
Flow cytometric analysis of apoptosis and necrosis in MCF-7 cells (double staining with annexin V Fluorescein isothiocyanate and propidium iodide (PI). Statistically significant difference in comparison to *control cells, #to the samples with doxorubicin (DOX). p<0.05 The values are the mean±SD of five independent experiments.
- Figure 5.
Caspase-3 activity in MCF-7 cells after incubation with doxorubicin (DOX) and compounds 1-5. Statistically significant difference in comparison to *control cells and #probes with doxorubicin at p<0.05. The values are the mean±SD of five independent experiments.
- Figure 6.
The effect of doxorubicin (DOX) and compounds 1-5 on the level of TUNEL-positive cells after 72 h exposure to drugs. Statistically significant difference in comparison to *control cells and #probes with DOX at p<0.05. The values are the mean±SD of three independent experiments.
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