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Research ArticleExperimental Studies

Attenuated Salmonella enterica Typhimurium Reduces Tumor Burden in an Autochthonous Breast Cancer Model

JEREMY DREES, MICHAEL MERTENSOTTO, GARVEY LIU, JAYANTH PANYAM, ARNOLD LEONARD, LANCE AUGUSTIN, JANET SCHOTTEL and DANIEL SALTZMAN
Anticancer Research February 2015, 35 (2) 843-849;
JEREMY DREES
1Department of Surgery, University of Minnesota, Minneapolis, MN, U.S.A.
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  • For correspondence: dree0036@umn.edu
MICHAEL MERTENSOTTO
1Department of Surgery, University of Minnesota, Minneapolis, MN, U.S.A.
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GARVEY LIU
2Department of Pharmaceutics, University of Minnesota, Minneapolis, MN, U.S.A.
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JAYANTH PANYAM
2Department of Pharmaceutics, University of Minnesota, Minneapolis, MN, U.S.A.
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ARNOLD LEONARD
1Department of Surgery, University of Minnesota, Minneapolis, MN, U.S.A.
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LANCE AUGUSTIN
1Department of Surgery, University of Minnesota, Minneapolis, MN, U.S.A.
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JANET SCHOTTEL
3Department of Biochemistry, Molecular Biology & Biophysics, University of Minnesota, Minneapolis, MN, U.S.A.
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DANIEL SALTZMAN
1Department of Surgery, University of Minnesota, Minneapolis, MN, U.S.A.
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Abstract

Background/Aim: Cancer treatment with attenuated Salmonella enterica Typhimurium (S. Typhimurium) has gained momentum in recent years. However, the effectiveness of this treatment has not been explored in autochthonous models. We report the efficacy of S. Typhimurium in mice with autochthonous mammary tumors. Materials and Methods: S. Typhimurium attenuated by deletion of cyclic adenosine monophosphate signaling, SalpNG.1, was injected into female BALB-neuT tumor-bearing mice. Mice were monitored for efficacy and sacrificed for mechanistic studies. Results: In treated mice, seven-week post-treatment tumor burden was reduced by 85% and median survival was increased by 88%. Efficacy was correlated with increased tumor-infiltrating CD8 and natural killer cells. In addition, SalpNG.1 treatment caused a systemic increase of monocytic myeloid-derived suppressor cells that accumulated to high numbers within tumor tissue. Bacteria were not detected in tumor tissue, suggesting that the observed efficacy was due to a systemic rather than a tumor-specific effect of the bacteria. Conclusion: S. Typhimurium treatment reduces tumor burden and increases survival in an autochthonous breast cancer model.

  • Salmonella
  • cancer therapy
  • breast cancer
  • BALB-neuT
  • autochthonous model
  • genetically-engineered
  • mouse model
  • immunotherapy
  • myeloid-derived suppressor cells
  • Received October 7, 2014.
  • Revision received November 4, 2014.
  • Accepted November 7, 2014.
  • Copyright© 2015 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved
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Anticancer Research: 35 (2)
Anticancer Research
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February 2015
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Attenuated Salmonella enterica Typhimurium Reduces Tumor Burden in an Autochthonous Breast Cancer Model
JEREMY DREES, MICHAEL MERTENSOTTO, GARVEY LIU, JAYANTH PANYAM, ARNOLD LEONARD, LANCE AUGUSTIN, JANET SCHOTTEL, DANIEL SALTZMAN
Anticancer Research Feb 2015, 35 (2) 843-849;

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Attenuated Salmonella enterica Typhimurium Reduces Tumor Burden in an Autochthonous Breast Cancer Model
JEREMY DREES, MICHAEL MERTENSOTTO, GARVEY LIU, JAYANTH PANYAM, ARNOLD LEONARD, LANCE AUGUSTIN, JANET SCHOTTEL, DANIEL SALTZMAN
Anticancer Research Feb 2015, 35 (2) 843-849;
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Keywords

  • Salmonella
  • cancer therapy
  • breast Cancer
  • BALB-neuT
  • autochthonous model
  • genetically-engineered
  • mouse model
  • immunotherapy
  • myeloid-derived suppressor cells
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