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Research ArticleClinical Studies

Carbon-ion Radiotherapy for Prostate Cancer: Analysis of Morbidities and Change in Health-related Quality of Life

HITOSHI ISHIKAWA, HIROYUKI KATOH, TAKUYA KAMINUMA, HIDEMASA KAWAMURA, KAZUTO ITO, HIROSHI MATSUI, JUNKO HIRATO, NOBUAKI SHIMIZU, YUTAKA TAKEZAWA, HIROSHI TSUJI, KAZUHIRO SUZUKI, TATSUYA OHNO, TAKASHI NAKANO and GROUP FOR GENITOURINARY TUMORS AT GUNMA HEAVY ION MEDICAL CENTER
Anticancer Research October 2015, 35 (10) 5559-5566;
HITOSHI ISHIKAWA
1Department of Radiation Oncology, Faculty of Medicine, University of Tsukuba, Ibaraki, Japan
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  • For correspondence: hishikawa{at}pmrc.tsukuba.ac.jp
HIROYUKI KATOH
2Heavy Ion Medical Research Center, Gunma University, Gunma, Japan
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TAKUYA KAMINUMA
2Heavy Ion Medical Research Center, Gunma University, Gunma, Japan
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HIDEMASA KAWAMURA
2Heavy Ion Medical Research Center, Gunma University, Gunma, Japan
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KAZUTO ITO
3Department of Urology, Gunma University Graduate School of Medicine, Gunma, Japan
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HIROSHI MATSUI
3Department of Urology, Gunma University Graduate School of Medicine, Gunma, Japan
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JUNKO HIRATO
4Department of Pathology, Gunma University Graduate School of Medicine, Gunma, Japan
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NOBUAKI SHIMIZU
5Department of Urology, Gunma Cancer Center, Gunma, Japan
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YUTAKA TAKEZAWA
6Department of Urology, Isesaki Municipal Hospital, Isesaki, Gunma, Japan
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HIROSHI TSUJI
7Research Center Hospital for Charged Particle Therapy, National Institute of Radiological Sciences, Chiba, Japan
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KAZUHIRO SUZUKI
2Heavy Ion Medical Research Center, Gunma University, Gunma, Japan
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TATSUYA OHNO
2Heavy Ion Medical Research Center, Gunma University, Gunma, Japan
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TAKASHI NAKANO
2Heavy Ion Medical Research Center, Gunma University, Gunma, Japan
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    Figure 1.

    A representative dose distribution of carbon-ion radiotherapy: axial view (A), sagittal view (B), and coronal view (C). Contours by light-yellow, green, and light-green lines indicate the initial planning target volume, prostate, and proximal seminal vesicles, respectively.

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    Figure 2.

    Overall survival and recurrence-free survival curves after carbon-ion radiotherapy for prostate cancer.

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    Figure 3.

    Normalized rectal volume receiving 10% (V10) to 100% (V100) of the prescribed dose for all treatment plans. The averages of the rectal V30, V50, V70, and V90 in the present study were 17.2±4.1%, 10.9±2.7%, 7.0±2.0%, and 3.6±1.2%, respectively.

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Anticancer Research
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October 2015
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Carbon-ion Radiotherapy for Prostate Cancer: Analysis of Morbidities and Change in Health-related Quality of Life
HITOSHI ISHIKAWA, HIROYUKI KATOH, TAKUYA KAMINUMA, HIDEMASA KAWAMURA, KAZUTO ITO, HIROSHI MATSUI, JUNKO HIRATO, NOBUAKI SHIMIZU, YUTAKA TAKEZAWA, HIROSHI TSUJI, KAZUHIRO SUZUKI, TATSUYA OHNO, TAKASHI NAKANO, GROUP FOR GENITOURINARY TUMORS AT GUNMA HEAVY ION MEDICAL CENTER
Anticancer Research Oct 2015, 35 (10) 5559-5566;

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Carbon-ion Radiotherapy for Prostate Cancer: Analysis of Morbidities and Change in Health-related Quality of Life
HITOSHI ISHIKAWA, HIROYUKI KATOH, TAKUYA KAMINUMA, HIDEMASA KAWAMURA, KAZUTO ITO, HIROSHI MATSUI, JUNKO HIRATO, NOBUAKI SHIMIZU, YUTAKA TAKEZAWA, HIROSHI TSUJI, KAZUHIRO SUZUKI, TATSUYA OHNO, TAKASHI NAKANO, GROUP FOR GENITOURINARY TUMORS AT GUNMA HEAVY ION MEDICAL CENTER
Anticancer Research Oct 2015, 35 (10) 5559-5566;
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Keywords

  • Carbon-ion therapy
  • Prostate cancer
  • toxicity
  • quality of life
  • hypofractionation
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